PMID- 34041870
OWN - NLM
STAT- MEDLINE
DCOM- 20220406
LR  - 20220406
IS  - 2057-4347 (Electronic)
IS  - 2057-4347 (Linking)
VI  - 7
IP  - 6
DP  - 2021 Dec
TI  - Comparison of the frequency of periodontal pathogenic species of diabetics and 
      non-diabetics and its relation to periodontitis severity, glycemic control and 
      body mass index.
PG  - 1080-1088
LID - 10.1002/cre2.453 [doi]
AB  - OBJECTIVES: To investigate common pathogenic bacteria of periodontal diseases 
      (PD) in patients with type 2 diabetes mellitus (T2DM) and its relationship with 
      PD severity, glycemic control and body mass index (BMI). MATERIAL AND METHODS: 
      This case-control study consisted of 55 patients with T2DM and 55 individuals as 
      control. Samples were collected from periodontal pockets. After DNA extraction, 
      using 16srRNA-specific primers, the presence of Aggregatibacter 
      actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Tannerella forsythia 
      (Tf), Prevotella intermedia (Pi), and Fusobacterium nucleatum (Fn) were examined 
      based on polymerase chain reaction method. RESULTS: Aa frequency was 
      significantly higher in in T2DM group than control. There were no significant 
      differences in the frequencies of Pg, Tf, Pi, and Fn between studied groups. 
      There were no significant differences between frequencies of studied bacteria in 
      different severities of periodontitis in T2DM group. Prevalence of Tf in T2DM 
      patients with moderate periodontitis was significantly higher than non-diabetics 
      with moderate periodontitis. There was no significant difference between the 
      frequency of bacteria in diabetics with good and poor glycemic control. There was 
      a significant difference between the frequencies of Pg in T2DM individuals with 
      different BMI levels. CONCLUSIONS: A higher frequency of detection of Aa was 
      found in diabetic when compared to non-diabetics. Glycemic control did not affect 
      the frequency distribution of studied bacteria in T2DM. Pg was identified in 
      higher frequency in overweight T2DM patients.
CI  - (c) 2021 The Authors. Clinical and Experimental Dental Research published by John 
      Wiley & Sons Ltd.
FAU - Akherati, Mojtaba
AU  - Akherati M
AD  - Student Research Committee, Birjand University of Medical Sciences, Birjand, 
      Iran.
FAU - Shafaei, Ebrahim
AU  - Shafaei E
AD  - Infectious Diseases Research Center, Birjand University of Medical Sciences, 
      Birjand, Iran.
FAU - Salehiniya, Hamid
AU  - Salehiniya H
AD  - Social Determinants of Health Research Center, Birjand University of Medical 
      Sciences, Birjand, Iran.
FAU - Abbaszadeh, Hamid
AU  - Abbaszadeh H
AUID- ORCID: 0000-0002-7443-0607
AD  - Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Birjand 
      University of Medical Sciences, Birjand, Iran.
LA  - eng
GR  - project# 456020/Vice Chancellor for Research, Birjand University of Medical 
      Sciences/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210526
PL  - United States
TA  - Clin Exp Dent Res
JT  - Clinical and experimental dental research
JID - 101692332
SB  - IM
MH  - Aggregatibacter actinomycetemcomitans/genetics
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Glycemic Control
MH  - Humans
MH  - *Periodontitis/epidemiology
MH  - Prevotella intermedia
PMC - PMC8638284
OTO - NOTNLM
OT  - bacteria
OT  - body mass index
OT  - diabetes mellitus
OT  - periodontal disease
OT  - periodontal index
COIS- The authors declare that there are no conflicts of interest in this study.
EDAT- 2021/05/28 06:00
MHDA- 2022/04/07 06:00
PMCR- 2021/05/26
CRDT- 2021/05/27 07:17
PHST- 2021/05/06 00:00 [revised]
PHST- 2021/03/13 00:00 [received]
PHST- 2021/05/11 00:00 [accepted]
PHST- 2021/05/28 06:00 [pubmed]
PHST- 2022/04/07 06:00 [medline]
PHST- 2021/05/27 07:17 [entrez]
PHST- 2021/05/26 00:00 [pmc-release]
AID - CRE2453 [pii]
AID - 10.1002/cre2.453 [doi]
PST - ppublish
SO  - Clin Exp Dent Res. 2021 Dec;7(6):1080-1088. doi: 10.1002/cre2.453. Epub 2021 May 
      26.