PMID- 34042414
OWN - NLM
STAT- MEDLINE
DCOM- 20210831
LR  - 20210831
IS  - 1528-1159 (Electronic)
IS  - 0362-2436 (Linking)
VI  - 46
IP  - 18
DP  - 2021 Sep 15
TI  - Assessment of the Minimum Clinically Important Difference in the Smartphone-based 
      6-minute Walking Test After Surgery for Lumbar Degenerative Disc Disease.
PG  - E959-E965
LID - 10.1097/BRS.0000000000003991 [doi]
AB  - STUDY DESIGN: Prospective cohort study. OBJECTIVE: The aim of this study was to 
      determine the minimum clinically important difference (MCID) of the 6-minute 
      walking test (6WT) after surgery for lumbar degenerative disc disease (DDD). 
      SUMMARY OF BACKGROUND DATA: The smartphone-based 6WT is a valid and reliable tool 
      to quantify objective functional impairment in patients with lumbar DDD. To date, 
      the MCID of the 6WT has not been described in patients with DDD. METHODS: We 
      assessed patients pre- and 6-weeks postoperatively, analyzing both raw 6-minute 
      walking distances (6WD; in meters) and standardized 6WT z scores. Three methods 
      were applied to compute MCID values using established patient-reported outcomes 
      measures (PROMs) as anchors (VAS back/leg pain, Zurich Claudication Questionnaire 
      [ZCQ], Core Outcome Measures Index [COMI]): average change, minimum detectable 
      change, and the change difference approach. RESULT: We studied 49 patients (59% 
      male) with a mean age of 55.5 +/- 15.8 years. The computation methods revealed MCID 
      values ranging from 81 m (z score of 0.9) based on the VAS back pain to 99 m (z 
      score of 1.0) based on the ZCQ physical function scale. The average MCID of the 
      6WT was 92 m (z score of 1.0). Based on the average MCID of raw 6WD values or 
      standardized z scores, 53% or 49% of patients classified as 6-week responders to 
      surgery for lumbar DDD, respectively. CONCLUSION: The MCID for the 6WT in lumbar 
      DDD patients is variable, depending on the calculation technique. We propose a 
      MCID of 92m (z score of 1.0), based on the average of all three methods. Using a 
      z score as MCID allows for the standardization of clinically meaningful change 
      and attenuates age- and sex-related differences.Level of Evidence: 3.
CI  - Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Zeitlberger, Anna M
AU  - Zeitlberger AM
AD  - Department of Neurosurgery, Kantonsspital St. Gallen, St. Gallen, Switzerland.
FAU - Sosnova, Marketa
AU  - Sosnova M
AD  - Department of Neurosurgery, Kantonsspital St. Gallen, St. Gallen, Switzerland.
FAU - Ziga, Michal
AU  - Ziga M
AD  - Department of Neurosurgery, Kantonsspital St. Gallen, St. Gallen, Switzerland.
FAU - Regli, Luca
AU  - Regli L
AD  - Department of Neurosurgery, University Hospital Zurich & Clinical Neuroscience 
      Center, University of Zurich, Zurich, Switzerland.
FAU - Bozinov, Oliver
AU  - Bozinov O
AD  - Department of Neurosurgery, Kantonsspital St. Gallen, St. Gallen, Switzerland.
FAU - Weyerbrock, Astrid
AU  - Weyerbrock A
AD  - Department of Neurosurgery, Kantonsspital St. Gallen, St. Gallen, Switzerland.
FAU - Stienen, Martin N
AU  - Stienen MN
AD  - Department of Neurosurgery, Kantonsspital St. Gallen, St. Gallen, Switzerland.
AD  - Department of Neurosurgery, University Hospital Zurich & Clinical Neuroscience 
      Center, University of Zurich, Zurich, Switzerland.
FAU - Maldaner, Nicolai
AU  - Maldaner N
AD  - Department of Neurosurgery, Kantonsspital St. Gallen, St. Gallen, Switzerland.
AD  - Department of Neurosurgery, University Hospital Zurich & Clinical Neuroscience 
      Center, University of Zurich, Zurich, Switzerland.
LA  - eng
SI  - ClinicalTrials.gov/NCT03977961
PT  - Journal Article
PL  - United States
TA  - Spine (Phila Pa 1976)
JT  - Spine
JID - 7610646
SB  - IM
MH  - Back Pain
MH  - Female
MH  - Humans
MH  - *Intervertebral Disc Degeneration/surgery
MH  - Lumbar Vertebrae/surgery
MH  - Male
MH  - Pain Measurement
MH  - Prospective Studies
MH  - Smartphone
MH  - Treatment Outcome
MH  - Walking
EDAT- 2021/05/28 06:00
MHDA- 2021/09/01 06:00
CRDT- 2021/05/27 10:42
PHST- 2021/05/28 06:00 [pubmed]
PHST- 2021/09/01 06:00 [medline]
PHST- 2021/05/27 10:42 [entrez]
AID - 00007632-202109150-00007 [pii]
AID - 10.1097/BRS.0000000000003991 [doi]
PST - ppublish
SO  - Spine (Phila Pa 1976). 2021 Sep 15;46(18):E959-E965. doi: 
      10.1097/BRS.0000000000003991.