PMID- 34043862
OWN - NLM
STAT- MEDLINE
DCOM- 20210901
LR  - 20210901
IS  - 1099-0461 (Electronic)
IS  - 1095-6670 (Linking)
VI  - 35
IP  - 8
DP  - 2021 Aug
TI  - Developmental toxicity of lead in rats after gestational exposure and the 
      protective role of taurine.
PG  - e22816
LID - 10.1002/jbt.22816 [doi]
AB  - The present study was conducted to investigate the potential adverse effect of Pb 
      on pregnant Sprague-Dawley rats and their fetuses after maternal exposure, on 
      gestational days (GD) 7-16. The possible protective role of taurine (TA), 
      administered throughout the gestation period (GD 1-20) against Pb toxicity, was 
      also evaluated. Pregnant rats were divided into four groups: Group 1 (control) 
      was given distilled water; Group 2 was exposed to Pb (250 ppm) in drinking water 
      (GD 7-16), whereas Group 3 received TA (50 mg/kg/day) by oral gavage (GD 
      1-20); Group 4 was exposed to Pb (GD 7-16), whereas pretreated with TA from GD 1 
      till the end of the gestation period. After termination on GD 20, maternal and 
      embryo-fetal outcomes were evaluated. Blood samples were collected for 
      hematological and biochemical parameters assessment. The results showed that, Pb 
      induced a significant reduction in the maternal body weight, weight gain, uterine 
      and placental weight, in addition to a high incidence of abortion and fetal 
      resorption. Meanwhile, fetuses demonstrated decreased body weight and length, 
      with a high rate of mortality as well as external and skeletal abnormalities. 
      Additionally, Pb induced severe hematological and biochemical alterations in both 
      dams and fetuses. The toxicity of Pb was further emphasized by placental 
      histopathological examination and hepatic DNA fragmentation. Pretreatment with TA 
      greatly attenuated the impact of Pb on both maternal and fetal parameters. 
      Moreover, TA alleviated the incidence of placental damage and hepatic DNA 
      fragmentation. The results highlight the potential prophylaxis role of TA against 
      maternal and developmental Pb toxicity.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Aglan, Hoda Samir
AU  - Aglan HS
AUID- ORCID: 0000-0001-6460-6501
AD  - Department of Animal Breeding and Husbandry, Institute of Animal Science, 
      University of Bonn, Bonn, Germany.
AD  - Pharmacology Department, National Organization for Drug Control and Research, 
      Giza, Egypt.
FAU - Safar, Marwa M
AU  - Safar MM
AUID- ORCID: 0000-0001-7238-5403
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 
      Cairo, Egypt.
FAU - Ain-Shoka, Afaf Abdel-Moniem
AU  - Ain-Shoka AA
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 
      Cairo, Egypt.
FAU - Kandil, Asmaa Munir
AU  - Kandil AM
AD  - Pharmacology Department, National Organization for Drug Control and Research, 
      Giza, Egypt.
FAU - Gebremedhn, Samuel
AU  - Gebremedhn S
AUID- ORCID: 0000-0002-9977-2347
AD  - Department of Biomedical Sciences, Animal Reproduction and Biotechnology 
      Laboratory, Colorado State University, Fort Collins, Colorado, USA.
FAU - Salilew-Wondim, Dessie
AU  - Salilew-Wondim D
AD  - Department of Animal Breeding and Husbandry, Institute of Animal Science, 
      University of Bonn, Bonn, Germany.
FAU - Schellander, Karl
AU  - Schellander K
AD  - Department of Animal Breeding and Husbandry, Institute of Animal Science, 
      University of Bonn, Bonn, Germany.
AD  - Center of Integrated Dairy Research, University of Bonn, Bonn, Germany.
FAU - Tesfaye, Dawit
AU  - Tesfaye D
AD  - Department of Animal Breeding and Husbandry, Institute of Animal Science, 
      University of Bonn, Bonn, Germany.
AD  - Department of Biomedical Sciences, Animal Reproduction and Biotechnology 
      Laboratory, Colorado State University, Fort Collins, Colorado, USA.
AD  - Center of Integrated Dairy Research, University of Bonn, Bonn, Germany.
LA  - eng
PT  - Journal Article
DEP - 20210527
PL  - United States
TA  - J Biochem Mol Toxicol
JT  - Journal of biochemical and molecular toxicology
JID - 9717231
RN  - 1EQV5MLY3D (Taurine)
RN  - 2P299V784P (Lead)
SB  - IM
MH  - Animals
MH  - Female
MH  - Lead/*toxicity
MH  - Maternal Exposure/*adverse effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced/metabolism/prevention & 
      control
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Taurine/*pharmacology
OTO - NOTNLM
OT  - DNA fragmentation
OT  - developmental toxicity
OT  - lead toxicity
OT  - placenta
OT  - taurine
EDAT- 2021/05/28 06:00
MHDA- 2021/09/02 06:00
CRDT- 2021/05/27 17:53
PHST- 2021/01/08 00:00 [revised]
PHST- 2020/03/11 00:00 [received]
PHST- 2021/05/18 00:00 [accepted]
PHST- 2021/05/28 06:00 [pubmed]
PHST- 2021/09/02 06:00 [medline]
PHST- 2021/05/27 17:53 [entrez]
AID - 10.1002/jbt.22816 [doi]
PST - ppublish
SO  - J Biochem Mol Toxicol. 2021 Aug;35(8):e22816. doi: 10.1002/jbt.22816. Epub 2021 
      May 27.