PMID- 34044517 OWN - NLM STAT- MEDLINE DCOM- 20210531 LR - 20210531 IS - 0376-2491 (Print) IS - 0376-2491 (Linking) VI - 101 IP - 20 DP - 2021 Jun 1 TI - [Interstitial lung disease revisited]. PG - 1453-1457 LID - 10.3760/cma.j.cn112137-2020831-02514 [doi] AB - Interstitial lung disease (ILD), consisting of more than 200 subtypes of diseases, is a large group of heterogeneous diseases characterized by varying degrees of alveolitis and pulmonary parenchymal fibrosis. There are many challenges in its diagnosis and treatment. In recent years, new understanding of the clinical classification, disease behavior, early diagnosis, and treatment of ILD has been obtained. The anti-fibrotic drugs have been expanded successfully from treatment of idiopathic pulmonary fibrosis (IPF) to progressive-fibrosing interstitial lung diseases (PF-ILD). A new international clinical practice guideline categorized hypersensitivity pneumonitis (HP) into two clinical phenotypes, namely nonfibrotic and fibrotic HP. The clinical classification of ILD according to disease behavior and a progressing fibrotic phenotype is of important value for the establishment of treatment strategies for patients with ILD. Interstitial pulmonary abnormalities (ILA) may represent the subclinical stages of different types of ILD, and long-term follow-up of ILA is key to improving the early diagnosis of ILD. Interstitial pneumonia with autoimmune features (IPAF) may represent an early phase or prodromal state of a connective tissue disease (CTD), and patients with IPAF need to be under longitudinal surveillance for evolution to CTD. FAU - Jiang, H D AU - Jiang HD AD - Department of Respiratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. FAU - Chen, B AU - Chen B AD - Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China. LA - chi PT - Journal Article PL - China TA - Zhonghua Yi Xue Za Zhi JT - Zhonghua yi xue za zhi JID - 7511141 SB - IM MH - *Alveolitis, Extrinsic Allergic/diagnosis MH - *Connective Tissue Diseases MH - Humans MH - *Idiopathic Pulmonary Fibrosis/diagnosis MH - Lung MH - *Lung Diseases, Interstitial/diagnosis MH - Tomography, X-Ray Computed EDAT- 2021/05/29 06:00 MHDA- 2021/06/01 06:00 CRDT- 2021/05/28 04:24 PHST- 2021/05/28 04:24 [entrez] PHST- 2021/05/29 06:00 [pubmed] PHST- 2021/06/01 06:00 [medline] AID - 10.3760/cma.j.cn112137-2020831-02514 [doi] PST - ppublish SO - Zhonghua Yi Xue Za Zhi. 2021 Jun 1;101(20):1453-1457. doi: 10.3760/cma.j.cn112137-2020831-02514.