PMID- 34044565
OWN - NLM
STAT- MEDLINE
DCOM- 20210611
LR  - 20220531
IS  - 2224-5839 (Electronic)
IS  - 2224-5820 (Linking)
VI  - 10
IP  - 5
DP  - 2021 May
TI  - Elevated B-type natriuretic peptide (BNP) and soluble thrombomodulin (sTM) 
      indicates severity and poor prognosis of sepsis.
PG  - 5561-5567
LID - 10.21037/apm-21-1048 [doi]
AB  - BACKGROUND: To study the predictive value of B-type natriuretic peptide (BNP) and 
      soluble thrombomodulin (sTM) in the severity stratification and prognosis 
      evaluation of sepsis. METHODS: The clinical data of 137 sepsis patients diagnosed 
      and treated in Sichuan Provincial People's Hospital from May 2018 to November 
      2020 were retrospectively analyzed. Meanwhile, 121 healthy individuals were 
      selected as the control group. Patients with sepsis were allocated into the mild 
      group, severe group, and shock group according to the severity. According to the 
      28-day prognosis, the patients were allocated into the death group and survival 
      group. The plasma BNP and serum sTM levels in different groups were compared, and 
      their prognostic value was evaluated. RESULTS: Patients with sepsis had 
      significantly higher levels of BNP and sTM than the healthy control group 
      (P<0.05). The levels of BNP and sTM in the mild group were significantly lower 
      than those in the severe group and shock group, and both BNP and sTM were 
      positively correlated with Acute Physiology and Chronic Health Status (APACHE) II 
      score (r=0.595, 0.516, P<0.05). The levels of BNP and sTM in the death group were 
      significantly higher than those in the survival group (P<0.05). The area under 
      curve (AUC) of BNP combined with sTM was significantly greater than that of BNP 
      or sTM alone for the prognosis of sepsis (P<0.05). When the cut-off value of BNP 
      was 625.68 pg/mL, the sensitivity and specificity were 77.42% and 89.42%, 
      respectively. When the cut-off value of sTM was 10.53 ng/mL, the sensitivity and 
      specificity were 83.87% and 94.34%, respectively. CONCLUSIONS: Patients with 
      sepsis have significantly higher serum BNP and sTM levels which are positively 
      correlated with the severity of the disease. Both of the 2 indexes have good 
      prognostic value, and the predictive value is higher when combined.
FAU - Yue, Lei
AU  - Yue L
AD  - Department of Medical Education, Sichuan Provincial People's Hospital, University 
      of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of 
      Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.
FAU - Deng, Xiyu
AU  - Deng X
AD  - Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, 
      Chengdu, China; Department of Digestive Internal Medicine, Sichuan Provincial 
      People's Hospital, University of Electronic Science and Technology of China, 
      Chengdu, China.
FAU - Yang, Mengdie
AU  - Yang M
AD  - Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, 
      Chengdu, China; Department of Gynaecology, Sichuan Provincial People's Hospital, 
      University of Electronic Science and Technology of China, Chengdu, China.
FAU - Li, Xin
AU  - Li X
AD  - Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, 
      Chengdu, China; Department of Emergency, Sichuan Provincial People's Hospital, 
      University of Electronic Science and Technology of China, Chengdu, China.
LA  - eng
PT  - Journal Article
DEP - 20210518
PL  - China
TA  - Ann Palliat Med
JT  - Annals of palliative medicine
JID - 101585484
RN  - 0 (THBD protein, human)
RN  - 0 (Thrombomodulin)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Humans
MH  - *Natriuretic Peptide, Brain
MH  - Prognosis
MH  - Retrospective Studies
MH  - *Sepsis
MH  - Thrombomodulin
OTO - NOTNLM
OT  - B-type natriuretic peptide (BNP)
OT  - prognosis
OT  - sepsis
OT  - severity
OT  - soluble thrombomodulin (sTM)
EDAT- 2021/05/29 06:00
MHDA- 2021/06/12 06:00
CRDT- 2021/05/28 05:36
PHST- 2021/03/18 00:00 [received]
PHST- 2021/05/13 00:00 [accepted]
PHST- 2021/05/29 06:00 [pubmed]
PHST- 2021/06/12 06:00 [medline]
PHST- 2021/05/28 05:36 [entrez]
AID - apm-21-1048 [pii]
AID - 10.21037/apm-21-1048 [doi]
PST - ppublish
SO  - Ann Palliat Med. 2021 May;10(5):5561-5567. doi: 10.21037/apm-21-1048. Epub 2021 
      May 18.