PMID- 34046097
OWN - NLM
STAT- MEDLINE
DCOM- 20211206
LR  - 20220423
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2021
DP  - 2021
TI  - Elevated Serum Small Dense Low-Density Lipoprotein Cholesterol May Increase the 
      Risk and Severity of Coronary Heart Disease and Predict Cardiovascular Events in 
      Patients with Type 2 Diabetes Mellitus.
PG  - 5597028
LID - 10.1155/2021/5597028 [doi]
LID - 5597028
AB  - BACKGROUND: Coronary heart disease (CHD) is a common and severe complication in 
      type 2 diabetes mellitus (T2DM) patients. Increased amount of circulatory small 
      dense low-density lipoprotein cholesterol (sdLDL-C) particles is known to be a 
      sign of dyslipidemia and can result in atherosclerosis. However, the association 
      between serum sdLDL-C levels and CHD in T2DM patients remains unclear. METHODS: A 
      total of 3684 T2DM patients who received selective coronary angiography (CAG) 
      were selected. For analyzing the association between sdLDL-C and CHD severity in 
      T2DM, the patients with CHD were further divided into four subgroups according to 
      the quartiles of sdLDL-C. A multivariate logistic regression was used for 
      analyzing the risks and severity of CHD. A total of 3427 patients with continuous 
      stable CHD were recruited and followed up for 5 years. RESULTS: Serum sdLDL-C 
      levels in the CHD group were significantly increased compared with those in the 
      non-CHD group [0.80 (0.49) mmol/L vs. 0.70 (0.30) mmol/L, p < 0.001]. The results 
      from CHD subgroup analysis indicated that the sdLDL-C levels in patients with 
      multiple-vessel disease and high Gensini score (GS) were significantly increased. 
      By adjusting the confounding factors and analyzing with multiple logistic 
      regression, we found that sdLDL-C independently correlated with the presence and 
      severity of CHD (CHD: OR = 2.257; multiple-vessel disease: OR = 3.288; high GS: 
      OR = 2.554). A total of 484 major cardiovascular events (MACEs) were documented. 
      After Kaplan-Meier analysis and chi-squared analysis, the incidence of MACEs in 
      the high sdLDL-C group was higher than that in the low sdLDL-C group (16.04% vs. 
      12.25%, p = 0.002). CONCLUSION: In T2DM patients, elevated serum sdLDL-C may 
      increase the severity of CHD and predict cardiovascular events in the future. 
      Therefore, serum sdLDL-C may be a potential biomarker for the surveillance of CHD 
      in T2DM patients.
CI  - Copyright (c) 2021 Juan Huang et al.
FAU - Huang, Juan
AU  - Huang J
AD  - Department of Traditional Chinese Medicine, Peking University International 
      Hospital, China.
FAU - Gu, Jun-Xu
AU  - Gu JX
AUID- ORCID: 0000-0001-8945-3345
AD  - Department of Clinical Laboratory, Peking University People's Hospital, China.
FAU - Bao, Hui-Zhang
AU  - Bao HZ
AD  - Department of Clinical Laboratory, Peking University People's Hospital, China.
FAU - Li, Shan-Shan
AU  - Li SS
AD  - Department of Clinical Laboratory, Peking University People's Hospital, China.
FAU - Yao, Xiao-Qin
AU  - Yao XQ
AD  - Department of Traditional Chinese Medicine, Peking University International 
      Hospital, China.
FAU - Yang, Ming
AU  - Yang M
AD  - Department of Clinical Laboratory, Peking University International Hospital, 
      China.
FAU - Li, Yang
AU  - Li Y
AD  - Department of Clinical Laboratory, Peking University International Hospital, 
      China.
FAU - Zhang, Ai-Min
AU  - Zhang AM
AD  - Department of Clinical Laboratory, Peking University People's Hospital, China.
FAU - Yin, Yue
AU  - Yin Y
AD  - Department of Clinical Laboratory, Peking University People's Hospital, China.
FAU - Zhang, Na
AU  - Zhang N
AD  - Department of Clinical Laboratory, Peking University People's Hospital, China.
FAU - Jia, Mei
AU  - Jia M
AUID- ORCID: 0000-0002-8270-2297
AD  - Department of Clinical Laboratory, Peking University People's Hospital, China.
FAU - Su, Ming
AU  - Su M
AUID- ORCID: 0000-0002-0252-7936
AD  - Department of Clinical Laboratory, Peking University People's Hospital, China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20210510
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, LDL)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cholesterol, LDL/*blood
MH  - Coronary Artery Disease/blood/*diagnosis/*etiology
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - *Patient Acuity
MH  - Risk Factors
PMC - PMC8128552
COIS- There is no conflict of interest.
EDAT- 2021/05/29 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/05/10
CRDT- 2021/05/28 07:25
PHST- 2021/02/03 00:00 [received]
PHST- 2021/04/27 00:00 [accepted]
PHST- 2021/05/28 07:25 [entrez]
PHST- 2021/05/29 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/05/10 00:00 [pmc-release]
AID - 10.1155/2021/5597028 [doi]
PST - epublish
SO  - Dis Markers. 2021 May 10;2021:5597028. doi: 10.1155/2021/5597028. eCollection 
      2021.