PMID- 34046099
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231111
IS  - 1920-454X (Electronic)
IS  - 1920-4531 (Print)
IS  - 1920-4531 (Linking)
VI  - 12
IP  - 2-3
DP  - 2021 Jun
TI  - Personalized Medicine in Oncology in the Developing World: Barriers and Concepts 
      to Improve Status Quo.
PG  - 50-60
LID - 10.14740/wjon1345 [doi]
AB  - Personalized medicine (PM) has revolutionized oncology management in high human 
      development indexed countries. By interrogating both disease and host factors 
      through a variety of tools, oncologists have been able to better target an 
      individual's cancer, leading to improved outcomes. But both the tools used to 
      define these variables, such as next generation sequencing, large 
      immunohistochemical and fluorescence in situ hybridization (FISH) panels, and the 
      weapons employed against each target are extremely expensive. The expenses have 
      to be measured as not only the direct cost to the patient but also the cost to 
      the system to develop and deploy the necessary infrastructure to optimally use 
      them. However, the concepts of predictive, timely prevention and PM have 
      demonstrated improvement in patient's satisfaction and cost effectiveness. In 
      this paper we will summarize the relevant barriers and challenges that limit the 
      implementation of PM in the developing world with an emphasis on the challenges 
      in Nigeria and Nepal.
CI  - Copyright 2021, Adeniji et al.
FAU - Adeniji, Adeoluwa Akeem
AU  - Adeniji AA
AD  - Oncology and Radiotherapy Department, Lagos University Teaching Hospital, Lagos, 
      Nigeria.
FAU - Dulal, Soniya
AU  - Dulal S
AD  - National Academy of Medical Sciences (NAMS), Bir Hospital, Kathmandu, Nepal.
FAU - Martin, Mike G
AU  - Martin MG
AD  - West Cancer Centre and Research Institute, Memphis, TN, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210514
PL  - Canada
TA  - World J Oncol
JT  - World journal of oncology
JID - 101564097
PMC - PMC8139741
OTO - NOTNLM
OT  - Barriers
OT  - Cost-efficacy
OT  - Developing world
OT  - Individualized patient profiling
OT  - Oncology
OT  - Patient stratification
OT  - Personalized medicine
COIS- None to declare.
EDAT- 2021/05/29 06:00
MHDA- 2021/05/29 06:01
PMCR- 2021/05/14
CRDT- 2021/05/28 07:25
PHST- 2020/10/24 00:00 [received]
PHST- 2020/12/10 00:00 [accepted]
PHST- 2021/05/28 07:25 [entrez]
PHST- 2021/05/29 06:00 [pubmed]
PHST- 2021/05/29 06:01 [medline]
PHST- 2021/05/14 00:00 [pmc-release]
AID - 10.14740/wjon1345 [doi]
PST - ppublish
SO  - World J Oncol. 2021 Jun;12(2-3):50-60. doi: 10.14740/wjon1345. Epub 2021 May 14.