PMID- 34046374
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210530
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 9
DP  - 2021
TI  - A Ketogenic Diet and the Treatment of Autism Spectrum Disorder.
PG  - 650624
LID - 10.3389/fped.2021.650624 [doi]
LID - 650624
AB  - Autism spectrum disorder (ASD) is characterized by stereotyped behavior and 
      deficits in communication and social interaction. There are no curative 
      treatments for children with ASD. The ketogenic diet (KD) is a high-fat, 
      appropriate-protein, and low-carbohydrate diet that mimics the fasting state of 
      the body and is proven beneficial in drug-resistant epilepsy and some other brain 
      diseases. An increasing number of studies demonstrated that a KD improved 
      autistic behavior, but the underlying mechanisms are not known. We reviewed the 
      neuroprotective role of a KD in ASD, which is likely mediated via improvements in 
      energy metabolism, reductions in antioxidative stress levels, control of 
      neurotransmitters, inhibition of the mammalian target of rapamycin (mTOR) 
      signaling pathway, and modulation of the gut microbiota. A KD is likely a safe 
      and effective treatment for ASD.
CI  - Copyright (c) 2021 Li, Liang, Fu, Han and Qin.
FAU - Li, Qinrui
AU  - Li Q
AD  - Department of Pediatrics, Peking University People's Hospital, Beijing, China.
FAU - Liang, Jingjing
AU  - Liang J
AD  - Department of Pediatrics, Peking University People's Hospital, Beijing, China.
FAU - Fu, Na
AU  - Fu N
AD  - Department of Pediatrics, Peking University People's Hospital, Beijing, China.
FAU - Han, Ying
AU  - Han Y
AD  - Department of Pediatrics, Peking University First Hospital, Beijing, China.
FAU - Qin, Jiong
AU  - Qin J
AD  - Department of Pediatrics, Peking University People's Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210511
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC8146910
OTO - NOTNLM
OT  - autism spectrum disorder
OT  - blood-brain barrier
OT  - gut microbiota
OT  - ketogenic diet
OT  - neuroprotection
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/05/29 06:00
MHDA- 2021/05/29 06:01
PMCR- 2021/05/11
CRDT- 2021/05/28 07:28
PHST- 2021/01/07 00:00 [received]
PHST- 2021/03/29 00:00 [accepted]
PHST- 2021/05/28 07:28 [entrez]
PHST- 2021/05/29 06:00 [pubmed]
PHST- 2021/05/29 06:01 [medline]
PHST- 2021/05/11 00:00 [pmc-release]
AID - 10.3389/fped.2021.650624 [doi]
PST - epublish
SO  - Front Pediatr. 2021 May 11;9:650624. doi: 10.3389/fped.2021.650624. eCollection 
      2021.