PMID- 34046505
OWN - NLM
STAT- MEDLINE
DCOM- 20211210
LR  - 20221019
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2021
DP  - 2021
TI  - Pain Management in People with Diabetes-Related Chronic Limb-Threatening 
      Ischemia.
PG  - 6699292
LID - 10.1155/2021/6699292 [doi]
LID - 6699292
AB  - Management of neuropathic pain in people with diabetes has been widely 
      investigated. However, little attention was paid to address ischemic-related pain 
      in patients with diabetes mellitus who suffered from chronic limb-threatening 
      ischemia (CLTI), the end stage of lower extremity arterial disease (LEAD). Pain 
      management has a tremendous influence on patients' quality of life and prognosis. 
      Poor management of this type of pain owing to the lack of full understanding 
      undermines patients' physical and mental quality of life, which often results in 
      a grim prognosis, such as depression, myocardial infarction, lower limb 
      amputation, and even mortality. In the present article, we review the current 
      strategy in the pain management of diabetes-related CLTI. The endovascular 
      therapy, pharmacological therapies, and other optional methods could be selected 
      following comprehensive assessments to mitigate ischemic-related pain, in line 
      with our current clinical practice. It is very important for clinicians and 
      patients to strengthen the understanding and build intervention strategy in 
      ischemic pain management and possible adverse consequence.
CI  - Copyright (c) 2021 Xiaoyan Jiang et al.
FAU - Jiang, Xiaoyan
AU  - Jiang X
AUID- ORCID: 0000-0002-1968-6810
AD  - Department of Endocrinology, Diabetic Foot Center, Chongqing University Central 
      Hospital, Chongqing Emergency Medical Center, Chongqing 400014, China.
FAU - Yuan, Yi
AU  - Yuan Y
AUID- ORCID: 0000-0002-5603-4723
AD  - Department of Endocrinology, Diabetic Foot Center, Chongqing University Central 
      Hospital, Chongqing Emergency Medical Center, Chongqing 400014, China.
FAU - Ma, Yu
AU  - Ma Y
AD  - Department of Endocrinology, Diabetic Foot Center, Chongqing University Central 
      Hospital, Chongqing Emergency Medical Center, Chongqing 400014, China.
FAU - Zhong, Miao
AU  - Zhong M
AUID- ORCID: 0000-0002-7815-7046
AD  - Department of Endocrinology, Diabetic Foot Center, Chongqing University Central 
      Hospital, Chongqing Emergency Medical Center, Chongqing 400014, China.
FAU - Du, Chenzhen
AU  - Du C
AUID- ORCID: 0000-0003-1796-6592
AD  - Department of Endocrinology, Diabetic Foot Center, Chongqing University Central 
      Hospital, Chongqing Emergency Medical Center, Chongqing 400014, China.
FAU - Boey, Johnson
AU  - Boey J
AUID- ORCID: 0000-0001-9466-7241
AD  - Department of Podiatry, National University of Hospital Singapore, Singapore 
      169608.
FAU - Armstrong, David G
AU  - Armstrong DG
AUID- ORCID: 0000-0003-1887-9175
AD  - Keck School of Medicine of University of Southern California, Los Angeles, CA 
      90033, USA.
FAU - Deng, Wuquan
AU  - Deng W
AUID- ORCID: 0000-0002-9883-5051
AD  - Department of Endocrinology, Diabetic Foot Center, Chongqing University Central 
      Hospital, Chongqing Emergency Medical Center, Chongqing 400014, China.
FAU - Duan, Xiaodong
AU  - Duan X
AUID- ORCID: 0000-0002-6295-5051
AD  - Department of Rehabilitation, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, Sichuan 646000, China.
LA  - eng
GR  - R01 DK124789/DK/NIDDK NIH HHS/United States
GR  - R44 DK102244/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20210508
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
SB  - IM
MH  - Chronic Disease
MH  - Diabetes Mellitus/diagnosis/epidemiology/*therapy
MH  - Humans
MH  - Ischemia/diagnosis/epidemiology/*therapy
MH  - *Pain Management/adverse effects
MH  - Peripheral Arterial Disease/diagnosis/epidemiology/*therapy
MH  - Quality of Life
MH  - Risk Factors
MH  - Treatment Outcome
PMC - PMC8128546
COIS- The authors declare no competing interests in this work.
EDAT- 2021/05/29 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/05/08
CRDT- 2021/05/28 07:30
PHST- 2020/12/23 00:00 [received]
PHST- 2021/04/19 00:00 [revised]
PHST- 2021/05/03 00:00 [accepted]
PHST- 2021/05/28 07:30 [entrez]
PHST- 2021/05/29 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/05/08 00:00 [pmc-release]
AID - 10.1155/2021/6699292 [doi]
PST - epublish
SO  - J Diabetes Res. 2021 May 8;2021:6699292. doi: 10.1155/2021/6699292. eCollection 
      2021.