PMID- 34046688
OWN - NLM
STAT- MEDLINE
DCOM- 20220719
LR  - 20220721
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Print)
IS  - 0172-8172 (Linking)
VI  - 42
IP  - 8
DP  - 2022 Aug
TI  - Clinical, radiologic and serologic profile of patients with interstitial 
      pneumonia with autoimmune features: a cross-sectional study.
PG  - 1431-1441
LID - 10.1007/s00296-021-04883-7 [doi]
AB  - The current study aimed to characterize patients from a rheumatology referral 
      center in north India, who satisfied the definition of interstitial pneumonia 
      with autoimmune features (IPAF) as given by the American Thoracic Society and 
      European Respiratory Society (ATS/ERS) consensus committee in 2015. Thirty-five 
      adult patients aged 18 years and above, fulfilling the 2015 ATS/ERS criteria for 
      IPAF were included in the study. The clinical and immunological profile, and 
      radiologic findings on high-resolution computerized tomography thorax were noted. 
      Antinuclear antibody (ANA) by indirect immunofluorescence at 1:320 titer and 
      myositis-specific antibody (MSA) assays were performed. Non-parametric tests were 
      used to compare variables between groups. The study cohort included predominantly 
      female patients with a mean age of 50.6 +/- 13 years and mean duration of 
      disease of 38.8 +/- 28.4 months. Majority of patients (49%) fulfilled the 
      morphologic and serologic domains as per the IPAF consensus criteria and 31% 
      patients had features in all three domains. Non-specific interstitial pneumonia 
      was the most common pattern observed in 77% patients. Raynaud's phenomenon and 
      inflammatory arthritis were the predominant autoimmune features. Pulmonary 
      arterial hypertension was documented in 60% of patients on echocardiography. 
      Positive ANA at 1:320 dilution was present in all 26 patients tested, whereas 
      extractable nuclear antigen and MSA assays detected autoantibodies in 49% and 51% 
      of patients respectively. IPAF predominantly affected females in the age group of 
      50 years and above, with varied autoimmune manifestations and autoantibody 
      profile.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Hazarika, Kasturi
AU  - Hazarika K
AUID- ORCID: 0000-0001-7579-136X
AD  - Department of Clinical Immunology and Rheumatology, King George's Medical 
      University, Lucknow, 226003, India.
FAU - Sahoo, Rasmi Ranjan
AU  - Sahoo RR
AUID- ORCID: 0000-0001-6616-4989
AD  - Department of Clinical Immunology and Rheumatology, King George's Medical 
      University, Lucknow, 226003, India.
FAU - Mohindra, Namita
AU  - Mohindra N
AUID- ORCID: 0000-0003-3043-1218
AD  - Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical 
      Sciences, Lucknow, 226014, India.
FAU - Wakhlu, Archana
AU  - Wakhlu A
AD  - Department of Clinical Immunology and Rheumatology, King George's Medical 
      University, Lucknow, 226003, India.
FAU - Manoj, Manesh
AU  - Manoj M
AUID- ORCID: 0000-0002-4031-136X
AD  - Department of Clinical Immunology and Rheumatology, King George's Medical 
      University, Lucknow, 226003, India.
FAU - Bafna, Prashant
AU  - Bafna P
AUID- ORCID: 0000-0001-9424-6412
AD  - Department of Clinical Immunology and Rheumatology, King George's Medical 
      University, Lucknow, 226003, India.
FAU - Garg, Rajiv
AU  - Garg R
AUID- ORCID: 0000-0002-5564-8037
AD  - Department of Respiratory Medicine, King George's Medical University, Lucknow, 
      226003, India.
FAU - Misra, Durga Prasanna
AU  - Misra DP
AUID- ORCID: 0000-0002-5035-7396
AD  - Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Post Graduate 
      Institute of Medical Sciences, Lucknow, 226014, India.
FAU - Agarwal, Vikas
AU  - Agarwal V
AUID- ORCID: 0000-0002-4508-1233
AD  - Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Post Graduate 
      Institute of Medical Sciences, Lucknow, 226014, India.
FAU - Wakhlu, Anupam
AU  - Wakhlu A
AUID- ORCID: 0000-0003-4342-9547
AD  - Department of Clinical Immunology and Rheumatology, King George's Medical 
      University, Lucknow, 226003, India. anupamwakhlu@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20210527
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Adult
MH  - Antibodies, Antinuclear
MH  - Autoantibodies
MH  - *Autoimmune Diseases/diagnostic imaging
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - *Lung Diseases, Interstitial/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - *Myositis
PMC - PMC8158082
OTO - NOTNLM
OT  - Autoantibodies
OT  - Connective tissue diseases
OT  - Idiopathic interstitial pneumonias
OT  - Interstitial lung disease
EDAT- 2021/05/29 06:00
MHDA- 2022/07/20 06:00
PMCR- 2021/05/27
CRDT- 2021/05/28 07:34
PHST- 2021/03/11 00:00 [received]
PHST- 2021/04/30 00:00 [accepted]
PHST- 2021/05/29 06:00 [pubmed]
PHST- 2022/07/20 06:00 [medline]
PHST- 2021/05/28 07:34 [entrez]
PHST- 2021/05/27 00:00 [pmc-release]
AID - 10.1007/s00296-021-04883-7 [pii]
AID - 4883 [pii]
AID - 10.1007/s00296-021-04883-7 [doi]
PST - ppublish
SO  - Rheumatol Int. 2022 Aug;42(8):1431-1441. doi: 10.1007/s00296-021-04883-7. Epub 
      2021 May 27.