PMID- 34049626
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20210601
LR  - 20210601
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 1167
DP  - 2021 Jul 4
TI  - Development of highly sensitive electrochemical sensor using new 
      graphite/acrylonitrile butadiene styrene conductive composite and 3D 
      printing-based alternative fabrication protocol.
PG  - 338566
LID - S0003-2670(21)00392-5 [pii]
LID - 10.1016/j.aca.2021.338566 [doi]
AB  - Here, a novel electrically conductive thermoplastic material composed of 
      graphite/acrylonitrile butadiene styrene (G/ABS) is reported for the first time. 
      This material was explored on the production of 3D printing-based electrochemical 
      sensors with enhanced sensitivity using a novel fabrication approach. The 
      developed G/ABS electrodes showed lower charge transfer resistance (157 vs. 
      3279 Omega), higher electroactive area (0.61 vs. 0.19 cm(2)) and peak currents ca. 
      69% higher when compared with electrodes fabricated using carbon black/polylactic 
      acid (CB/PLA) commercial filament, which has been widely explored in recent 
      literature. Moreover, the G/ABS sensor provided satisfactory repeatability, 
      reproducibility and stability (relative standard deviations (RSDs) were 1.14%, 
      6.81% and 10.62%, respectively). This improved performance can be attributed to 
      the fabrication protocol developed here, which allows the incorporation of 
      greater amounts of conductive material in the polymeric matrix. The G/ABS 
      electrode also required a simpler and quicker protocol for activation when 
      compared to CB/PLA. As proof of concept, the G/ABS sensor was employed for 
      electroanalytical quantification of paracetamol (PAR) in pharmaceutical products. 
      The linear concentration range was observed from 0.20 to 30 mumol L(-1) and the 
      limit of detection achieved was 54 nmol L(-1), much lower than several recent 
      studies dealing with the same analyte. The sensitivity of the G/ABS electrode 
      regarding PAR was also far better when compared to CB/PLA sensor (0.50 muA/mumol 
      L(-1) vs. 0.12 muA/mumol L(-1)). Analyses in commercial pill samples showed good 
      accuracy (recoveries ca. 108%) and precision (RSDs < 5%), suggesting great 
      potential for use of this novel conductive thermoplastic in electroanalytical 
      applications based on 3D printing.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Petroni, Jacqueline Marques
AU  - Petroni JM
AD  - Chemistry Institute, Federal University of Mato Grosso Do Sul, Campo Grande, MS, 
      79074-460, Brazil.
FAU - Neves, Matheus Meneguel
AU  - Neves MM
AD  - Chemistry Institute, Federal University of Mato Grosso Do Sul, Campo Grande, MS, 
      79074-460, Brazil.
FAU - de Moraes, Natalia Canhete
AU  - de Moraes NC
AD  - Chemistry Institute, Federal University of Mato Grosso Do Sul, Campo Grande, MS, 
      79074-460, Brazil.
FAU - Bezerra da Silva, Rodrigo Amorim
AU  - Bezerra da Silva RA
AD  - Instituto de Quimica, Universidade Federal de Uberlandia, 38500-000, Monte 
      Carmelo, MG, Brazil.
FAU - Ferreira, Valdir Souza
AU  - Ferreira VS
AD  - Chemistry Institute, Federal University of Mato Grosso Do Sul, Campo Grande, MS, 
      79074-460, Brazil.
FAU - Lucca, Bruno Gabriel
AU  - Lucca BG
AD  - Chemistry Institute, Federal University of Mato Grosso Do Sul, Campo Grande, MS, 
      79074-460, Brazil. Electronic address: bruno.lucca@ufms.br.
LA  - eng
PT  - Journal Article
DEP - 20210429
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
SB  - IM
OTO - NOTNLM
OT  - Additive manufacturing
OT  - Carbon electrode
OT  - Drug analysis
OT  - Electroanalysis
OT  - Paracetamol
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/05/30 06:00
MHDA- 2021/05/30 06:01
CRDT- 2021/05/29 05:30
PHST- 2020/12/29 00:00 [received]
PHST- 2021/03/31 00:00 [revised]
PHST- 2021/04/21 00:00 [accepted]
PHST- 2021/05/29 05:30 [entrez]
PHST- 2021/05/30 06:00 [pubmed]
PHST- 2021/05/30 06:01 [medline]
AID - S0003-2670(21)00392-5 [pii]
AID - 10.1016/j.aca.2021.338566 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2021 Jul 4;1167:338566. doi: 10.1016/j.aca.2021.338566. Epub 2021 
      Apr 29.