PMID- 34049793
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20210622
IS  - 1437-7780 (Electronic)
IS  - 1341-321X (Linking)
VI  - 27
IP  - 8
DP  - 2021 Aug
TI  - Long-term trend in serum (1,3)-beta-D-glucan level in a man with chronic 
      disseminated candidiasis treated with corticosteroids.
PG  - 1258-1260
LID - S1341-321X(21)00134-3 [pii]
LID - 10.1016/j.jiac.2021.05.005 [doi]
AB  - Chronic disseminated candidiasis (CDC) is a type of invasive candidiasis. CDC 
      commonly appears in the neutrophil recovery phase after chemotherapy in patients 
      with hematologic malignancies, and immune reconstitution inflammatory syndrome 
      (IRIS) is thought to play a major role in CDC development. This report describes 
      the case of a 33-year-old man with CDC as a complication of acute myeloid 
      leukemia. We describe the clinical course, body temperature, therapy, and 
      (1,3)-beta-D-glucan (BDG) levels over the course of 22 months. He was initially 
      treated with antifungals, but corticosteroids were added because of a 
      persistently elevated body temperature, which we attributed to IRIS. After 
      starting corticosteroids, his clinical condition improved, but his BDG levels 
      became markedly elevated. We hypothesize that the suppression of the excessive 
      immune response by corticosteroids lead to granuloma collapse, fungal release, 
      and hematogenous dissemination, resulting in elevated BDG levels. The patient's 
      condition gradually improved over the course of follow-up.
CI  - Copyright (c) 2021 Japanese Society of Chemotherapy and The Japanese Association 
      for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
FAU - Shirahige, Tomoyuki
AU  - Shirahige T
AD  - Department of Infectious Diseases, Nagasaki University Graduate School of 
      Biomedical Sciences, 1-12-4, Sakamoto, Nagasaki, 852-8102, Japan; Medical 
      Education Development Centre, Nagasaki University Hospital, 1-7-1, Sakamoto, 
      Nagasaki, 852-8102, Japan. Electronic address: tomoshirahige@gmail.com.
FAU - Tashiro, Masato
AU  - Tashiro M
AD  - Department of Infectious Diseases, Nagasaki University Graduate School of 
      Biomedical Sciences, 1-12-4, Sakamoto, Nagasaki, 852-8102, Japan; Infection 
      Control and Education Centre, Nagasaki University Hospital, 1-7-1, Sakamoto, 
      Nagasaki, 852-8102, Japan. Electronic address: mtashiro@nagasaki-u.ac.jp.
FAU - Taguchi, Masataka
AU  - Taguchi M
AD  - Department of Hematology, Nagasaki University Hospital, 1-7-1, Sakamoto, 
      Nagasaki, 852-8102, Japan. Electronic address: mtaguchi-ngs@umin.org.
FAU - Miyazaki, Yasushi
AU  - Miyazaki Y
AD  - Department of Hematology, Nagasaki University Hospital, 1-7-1, Sakamoto, 
      Nagasaki, 852-8102, Japan. Electronic address: y-miyaza@nagasaki-u.ac.jp.
FAU - Shibuya, Kazutoshi
AU  - Shibuya K
AD  - Department of Surgical Pathology, School of Medicine, Toho University, Tokyo, 
      Japan 6-11-1, Omori-nishi Ota-ku, Tokyo, 143-8541, Japan. Electronic address: 
      kaz@med.toho-u.ac.jp.
FAU - Izumikawa, Koichi
AU  - Izumikawa K
AD  - Department of Infectious Diseases, Nagasaki University Graduate School of 
      Biomedical Sciences, 1-12-4, Sakamoto, Nagasaki, 852-8102, Japan; Infection 
      Control and Education Centre, Nagasaki University Hospital, 1-7-1, Sakamoto, 
      Nagasaki, 852-8102, Japan. Electronic address: koizumik@nagasaki-u.ac.jp.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20210526
PL  - Netherlands
TA  - J Infect Chemother
JT  - Journal of infection and chemotherapy : official journal of the Japan Society of 
      Chemotherapy
JID - 9608375
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Antifungal Agents)
RN  - 0 (Proteoglycans)
RN  - 0 (beta-Glucans)
RN  - 3X48A86C8K (polysaccharide-K)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Adult
MH  - Antifungal Agents/therapeutic use
MH  - *Candidiasis, Invasive/drug therapy
MH  - Humans
MH  - Male
MH  - Proteoglycans
MH  - *beta-Glucans
OTO - NOTNLM
OT  - (1,3)-beta-D-glucan
OT  - Chronic disseminated candidiasis
OT  - Corticosteroid therapy
OT  - Immune reconstitution inflammatory syndrome
EDAT- 2021/05/30 06:00
MHDA- 2021/06/23 06:00
CRDT- 2021/05/29 05:37
PHST- 2020/11/18 00:00 [received]
PHST- 2021/03/17 00:00 [revised]
PHST- 2021/05/08 00:00 [accepted]
PHST- 2021/05/30 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2021/05/29 05:37 [entrez]
AID - S1341-321X(21)00134-3 [pii]
AID - 10.1016/j.jiac.2021.05.005 [doi]
PST - ppublish
SO  - J Infect Chemother. 2021 Aug;27(8):1258-1260. doi: 10.1016/j.jiac.2021.05.005. 
      Epub 2021 May 26.