PMID- 34051134
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 1365-2982 (Electronic)
IS  - 1350-1925 (Linking)
VI  - 33
IP  - 9
DP  - 2021 Sep
TI  - Low FODMAPs diet or usual dietary advice for the treatment of refractory 
      gastroesophageal reflux disease: An open-labeled randomized trial.
PG  - e14181
LID - 10.1111/nmo.14181 [doi]
AB  - BACKGROUND: The low FODMAPs (fermentable oligo-, di-, monosaccharides, and 
      polyols) diet improves lower gastrointestinal symptoms. Patients suffering from 
      proton pump inhibitor (PPI) refractory gastroesophageal reflux disease (GERD) 
      have limited treatment options. We investigated the efficacy of a low FODMAPs 
      diet in patients with PPI refractory GERD. METHODS: This multicenter, randomized, 
      open-label study compared the efficacy of a 4-week low FODMAPs diet and usual 
      dietary advice (ie, low-fat diet and head of bed elevation) in patients with 
      symptomatic PPI refractory GERD, defined by a Reflux Disease Questionnaire (RDQ) 
      score >3 and abnormal pH-impedance monitoring on PPIs. The primary endpoint was 
      the percentage of responders (RDQ </=3) at the end of the diet. RESULTS: Thirty-one 
      patients (55% women, median age 45 years) were included, 16 randomized in the low 
      FODMAPs diet group and 15 in the usual dietary advice group. Adherence to the 
      assigned diet was good, with a significant difference in the FODMAPs intake per 
      day between the low FODMAPs diet (2.5 g) and the usual dietary advice group 
      (13 g) (p < 0.001). There was no difference in response rates (RDQ score </=3) 
      between the low FODMAPs diet (6/16, 37.5%) and usual dietary advice (3/15, 20%) 
      groups (p = 0.43). Total RDQ score and dyspepsia subscore decreased significantly 
      over time in both groups (p = 0.002), with no difference according to the 
      assigned diet group (p = 0.85). CONCLUSION: Low FODMAPs diet and usual dietary 
      advice have similar but limited beneficial effects on symptoms in patients with 
      PPI refractory GERD.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Riviere, Pauline
AU  - Riviere P
AUID- ORCID: 0000-0002-1262-2806
AD  - Centre Medico-Chirurgical Magellan, Hopital Haut-Leveque, CHU de Bordeaux, 
      Bordeaux, France.
AD  - INSERM CIC 1401, Universite de Bordeaux, Bordeaux, France.
FAU - Vauquelin, Blandine
AU  - Vauquelin B
AD  - Centre Medico-Chirurgical Magellan, Hopital Haut-Leveque, CHU de Bordeaux, 
      Bordeaux, France.
AD  - INSERM CIC 1401, Universite de Bordeaux, Bordeaux, France.
FAU - Rolland, Emiliane
AU  - Rolland E
AD  - Centre Medico-Chirurgical Magellan, Hopital Haut-Leveque, CHU de Bordeaux, 
      Bordeaux, France.
AD  - INSERM CIC 1401, Universite de Bordeaux, Bordeaux, France.
FAU - Melchior, Chloe
AU  - Melchior C
AD  - Gastroenterology Department and INSERM CIC-CRB 1404, Rouen University Hospital, 
      Rouen Cedex, France.
AD  - INSERM UMR 1073, Institute for Research and Innovation in Biomedicine, Normandy 
      University, Rouen, France.
FAU - Roman, Sabine
AU  - Roman S
AUID- ORCID: 0000-0002-7798-7638
AD  - Digestive Physiology, Hopital E Herriot, Hospices Civils de Lyon, Universite de 
      Lyon, Lyon, France.
AD  - Inserm U1032, LabTAU, Universite de Lyon, Lyon, France.
FAU - Bruley des Varannes, Stanislas
AU  - Bruley des Varannes S
AD  - Gastroenterology Department, CHU de Nantes, Institut des Maladies de l'Appareil 
      Digestif, IMAD CIC 1413, Universite de Nantes, Nantes, France.
FAU - Mion, Francois
AU  - Mion F
AD  - Digestive Physiology, Hopital E Herriot, Hospices Civils de Lyon, Universite de 
      Lyon, Lyon, France.
AD  - Inserm U1032, LabTAU, Universite de Lyon, Lyon, France.
FAU - Gourcerol, Guillaume
AU  - Gourcerol G
AUID- ORCID: 0000-0001-8220-9155
AD  - INSERM UMR 1073, Institute for Research and Innovation in Biomedicine, Normandy 
      University, Rouen, France.
AD  - Physiology Department and INSERM CIC-CRB 1404, Rouen University Hospital, Rouen 
      Cedex, France.
FAU - Sacher-Huvelin, Sylvie
AU  - Sacher-Huvelin S
AD  - Gastroenterology Department, CHU de Nantes, Institut des Maladies de l'Appareil 
      Digestif, IMAD CIC 1413, Universite de Nantes, Nantes, France.
FAU - Zerbib, Frank
AU  - Zerbib F
AUID- ORCID: 0000-0002-6802-2121
AD  - Centre Medico-Chirurgical Magellan, Hopital Haut-Leveque, CHU de Bordeaux, 
      Bordeaux, France.
AD  - INSERM CIC 1401, Universite de Bordeaux, Bordeaux, France.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20210529
PL  - England
TA  - Neurogastroenterol Motil
JT  - Neurogastroenterology and motility
JID - 9432572
SB  - IM
MH  - Adult
MH  - Diet, Carbohydrate-Restricted/*methods
MH  - Female
MH  - Fermented Foods
MH  - Gastroesophageal Reflux/*diet therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - clinical trial
OT  - gastroesophageal reflux disease
OT  - low FODMAPs diet
OT  - refractory gastroesophageal reflux disease
EDAT- 2021/05/30 06:00
MHDA- 2022/02/01 06:00
CRDT- 2021/05/29 17:07
PHST- 2021/04/29 00:00 [revised]
PHST- 2020/10/27 00:00 [received]
PHST- 2021/05/03 00:00 [accepted]
PHST- 2021/05/30 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/05/29 17:07 [entrez]
AID - 10.1111/nmo.14181 [doi]
PST - ppublish
SO  - Neurogastroenterol Motil. 2021 Sep;33(9):e14181. doi: 10.1111/nmo.14181. Epub 
      2021 May 29.