PMID- 34052108
OWN - NLM
STAT- MEDLINE
DCOM- 20220127
LR  - 20220127
IS  - 1938-0666 (Electronic)
IS  - 1526-8209 (Linking)
VI  - 21
IP  - 6
DP  - 2021 Dec
TI  - Dietary Insulin Index and Insulin Load in Relation to Breast Cancer: Findings 
      from a Case-Control Study.
PG  - e665-e674
LID - S1526-8209(21)00086-0 [pii]
LID - 10.1016/j.clbc.2021.04.008 [doi]
AB  - BACKGROUND: No data are available on the association between dietary insulin 
      index (DII) and dietary insulin load (DIL) and the risk of breast cancer (BC). 
      PATIENTS AND METHODS: This hospital-based case-control study enrolled 150 newly 
      diagnosed cases of BC and 150 age-matched controls. All cases were patients with 
      pathologically confirmed BC, with no history of any type of other pathologically 
      confirmed cancers. Controls were selected from visitors, relatives, and friends 
      of non-cancer patients in other wards who had no family relationships with the 
      cases. We assessed the dietary intakes of study participants using a validated 
      147-item semiquantitative food frequency questionnaire. DII and DIL were obtained 
      from previously published data. RESULTS: A significant positive association was 
      found between DII and BC (odds ratio [OR], 1.82; 95% confidence interval [CI], 
      1.02-3.25), such that after considering energy intake and age, participants in 
      the highest tertile of DII had 1.86 times greater risk of BC than those in the 
      lowest tertile (OR, 1.86; 95% CI, 1.03-3.35). However, this association became 
      non-significant after controlling for further potential risk factors (OR, 3.26; 
      95% CI, 0.9-11.7). Furthermore, we observed a significant positive association 
      between DIL and BC (OR, 1.9; 95% CI, 1.06-3.40). The association remained 
      significant even after controlling for age and energy intake. Further controlling 
      for other potential confounders resulted in the disappearance of the association 
      (OR, 3.06; 95% CI, 0.87-10.6). CONCLUSION: Adherence to a diet with high DII and 
      DIL was not associated with odds of BC after controlling for potential 
      confounders.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Sheikhhossein, Fatemeh
AU  - Sheikhhossein F
AD  - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Shab-Bidar, Sakineh
AU  - Shab-Bidar S
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Amini, Mohammad Reza
AU  - Amini MR
AD  - Department of Clinical Nutrition, Faculty of Nutrition Sciences and Food 
      Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Hosseini, Fatemeh
AU  - Hosseini F
AD  - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Imani, Hossein
AU  - Imani H
AD  - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran. Electronic address: 
      h-imani@sina.tums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20210424
PL  - United States
TA  - Clin Breast Cancer
JT  - Clinical breast cancer
JID - 100898731
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Breast Neoplasms/diagnosis/*etiology/*metabolism
MH  - Case-Control Studies
MH  - Diet/*adverse effects/statistics & numerical data
MH  - Dietary Carbohydrates/*adverse effects
MH  - Female
MH  - Glycemic Load
MH  - Health Behavior
MH  - Humans
MH  - Insulin/*metabolism
MH  - Middle Aged
MH  - Risk Factors
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Diet
OT  - FFQ
OT  - Hyperinsulinemia
OT  - Iran
OT  - Nutrition epidemiolog
EDAT- 2021/05/31 06:00
MHDA- 2022/01/28 06:00
CRDT- 2021/05/30 20:37
PHST- 2020/12/19 00:00 [received]
PHST- 2021/03/20 00:00 [revised]
PHST- 2021/04/16 00:00 [accepted]
PHST- 2021/05/31 06:00 [pubmed]
PHST- 2022/01/28 06:00 [medline]
PHST- 2021/05/30 20:37 [entrez]
AID - S1526-8209(21)00086-0 [pii]
AID - 10.1016/j.clbc.2021.04.008 [doi]
PST - ppublish
SO  - Clin Breast Cancer. 2021 Dec;21(6):e665-e674. doi: 10.1016/j.clbc.2021.04.008. 
      Epub 2021 Apr 24.