PMID- 34052968
OWN - NLM
STAT- MEDLINE
DCOM- 20220406
LR  - 20220406
IS  - 1473-4230 (Electronic)
IS  - 1473-4222 (Linking)
VI  - 21
IP  - 1
DP  - 2022 Feb
TI  - Delineating the Decussating Dentato-rubro-thalamic Tract and Its Connections in 
      Humans Using Diffusion Spectrum Imaging Techniques.
PG  - 101-115
LID - 10.1007/s12311-021-01283-2 [doi]
AB  - The objective of this study was to identify the decussating 
      dentato-rubro-thalamic tract (d-DRTT) and its afferent and efferent connections 
      in healthy humans using diffusion spectrum imaging (DSI) techniques. In the 
      present study, the trajectory and lateralization of the d-DRTT was explored using 
      data from subjects in the Massachusetts General Hospital-Human Connectome Project 
      adult diffusion dataset. The afferent and efferent networks that compose the 
      cerebello-thalamo-cerebral pathways were also reconstructed. Correlation analysis 
      was performed to identify interrelationships between subdivisions of the 
      cerebello-dentato-rubro-thalamic and thalamo-cerebral connections. The d-DRTT was 
      visualized bilaterally in 28 subjects. According to a normalized quantitative 
      anisotropy and lateralization index evaluation, the left and right d-DRTT were 
      relatively symmetric. Afferent regions were found mainly in the posterior 
      cerebellum, especially the entire lobule VII (crus I, II and VIIb). Efferent 
      fibers mainly are projected to the contralateral frontal cortex, including the 
      motor and nonmotor regions. Correlations between cerebello-thalamic connections 
      and thalamo-cerebral connections were positive, including the lobule VIIa (crus I 
      and II) to the medial prefrontal cortex (MPFC) and the dorsolateral prefrontal 
      cortex and lobules VI, VIIb, VIII, and IX, to the MPFC and motor and premotor 
      areas. These results provide DSI-based tratographic evidence showing segregated 
      and parallel cerebellar outputs to cerebral regions. The posterior cerebellum may 
      play an important role in supporting and handling cognitive activities through 
      d-DRTT. Future studies will allow for a more comprehensive understanding of 
      cerebello-cerebral connections.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Ou, Si-Qi
AU  - Ou SQ
AD  - Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 
      100053, China.
FAU - Wei, Peng-Hu
AU  - Wei PH
AD  - Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 
      100053, China.
FAU - Fan, Xiao-Tong
AU  - Fan XT
AD  - Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 
      100053, China.
FAU - Wang, Yi-He
AU  - Wang YH
AD  - Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 
      100053, China.
FAU - Meng, Fei
AU  - Meng F
AD  - Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 
      100053, China.
FAU - Li, Mu-Yang
AU  - Li MY
AD  - Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 
      100053, China.
FAU - Shan, Yong-Zhi
AU  - Shan YZ
AD  - Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 
      100053, China.
FAU - Zhao, Guo-Guang
AU  - Zhao GG
AD  - Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 
      100053, China. ggzhao@vip.sina.com.
LA  - eng
PT  - Journal Article
DEP - 20210529
PL  - United States
TA  - Cerebellum
JT  - Cerebellum (London, England)
JID - 101089443
SB  - IM
MH  - Adult
MH  - Cerebellum/diagnostic imaging
MH  - Diffusion Magnetic Resonance Imaging
MH  - Humans
MH  - *Motor Cortex
MH  - Neural Pathways/diagnostic imaging
MH  - *Thalamus/diagnostic imaging
OTO - NOTNLM
OT  - Cerebellum
OT  - Dentato-rubro-thalamic tract
OT  - Diffusion spectrum imaging
OT  - High angular resolution diffusion imaging
OT  - Human Connectome Project
EDAT- 2021/05/31 06:00
MHDA- 2022/04/07 06:00
CRDT- 2021/05/30 21:10
PHST- 2021/05/19 00:00 [accepted]
PHST- 2021/05/31 06:00 [pubmed]
PHST- 2022/04/07 06:00 [medline]
PHST- 2021/05/30 21:10 [entrez]
AID - 10.1007/s12311-021-01283-2 [pii]
AID - 10.1007/s12311-021-01283-2 [doi]
PST - ppublish
SO  - Cerebellum. 2022 Feb;21(1):101-115. doi: 10.1007/s12311-021-01283-2. Epub 2021 
      May 29.