PMID- 34055083
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240402
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 22
IP  - 1
DP  - 2021 Jul
TI  - Bioinformatics identification of hub genes and signaling pathways regulated by 
      intravenous immunoglobulin treatment in acute Kawasaki disease.
PG  - 784
LID - 10.3892/etm.2021.10216 [doi]
LID - 784
AB  - Kawasaki disease (KD) is an acute, self-limiting form of vasculitis commonly 
      encountered in infants and young children. Intravenous immunoglobulin (IVIG) is 
      the primary drug used for the treatment of KD, which may significantly reduce the 
      occurrence of coronary artery lesions. However, the specific molecular profile 
      changes of KD caused by IVIG treatment have remained elusive and require further 
      research. The present study was designed to identify key genes, pathways and 
      immune cells affected by IVIG treatment using multiple bioinformatics analysis 
      methods. The results suggested that myeloid cells and neutrophils were affected 
      by IVIG treatment. Kyoto Encyclopedia of Genes and Genomes pathway analysis 
      identified that hematopoietic cell lineages and osteoclast differentiation may 
      have an important role in the mechanism of action of IVIG treatment. Immune cell 
      analysis indicated that the levels of monocytes, M1 macrophages, neutrophils and 
      platelets were markedly changed in patients with KD after vs. prior to IVIG 
      treatment. The key upregulated genes, including ZW10 interacting kinetochore 
      protein, GINS complex subunit 1 and microRNA-30b-3p in whole blood cells of 
      patients with KD following treatment with IVIG indicated that these IVIG-targeted 
      molecules may have important roles in KD. In addition, these genes were further 
      examined by literature review and indicated to be involved in cell proliferation, 
      apoptosis and virus-related immune response in patients with KD. Therefore, the 
      present results may provide novel insight into the mechanisms of action of IVIG 
      treatment for KD.
CI  - Copyright: (c) Huang et al.
FAU - Huang, Hongbiao
AU  - Huang H
AD  - Institute of Pediatric Research, Children's Hospital of Soochow University, 
      Suzhou, Jiangsu 215025, P.R. China.
FAU - Xu, Lei
AU  - Xu L
AD  - Institute of Pediatric Research, Children's Hospital of Soochow University, 
      Suzhou, Jiangsu 215025, P.R. China.
FAU - Ding, Yueyue
AU  - Ding Y
AD  - Institute of Pediatric Research, Children's Hospital of Soochow University, 
      Suzhou, Jiangsu 215025, P.R. China.
FAU - Qin, Jie
AU  - Qin J
AD  - Institute of Pediatric Research, Children's Hospital of Soochow University, 
      Suzhou, Jiangsu 215025, P.R. China.
FAU - Huang, Chengcheng
AU  - Huang C
AD  - Institute of Pediatric Research, Children's Hospital of Soochow University, 
      Suzhou, Jiangsu 215025, P.R. China.
FAU - Li, Xuan
AU  - Li X
AD  - Institute of Pediatric Research, Children's Hospital of Soochow University, 
      Suzhou, Jiangsu 215025, P.R. China.
FAU - Tang, Yunjia
AU  - Tang Y
AD  - Institute of Pediatric Research, Children's Hospital of Soochow University, 
      Suzhou, Jiangsu 215025, P.R. China.
FAU - Qian, Guanghui
AU  - Qian G
AD  - Institute of Pediatric Research, Children's Hospital of Soochow University, 
      Suzhou, Jiangsu 215025, P.R. China.
FAU - Lv, Haitao
AU  - Lv H
AD  - Institute of Pediatric Research, Children's Hospital of Soochow University, 
      Suzhou, Jiangsu 215025, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20210519
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC8145699
OTO - NOTNLM
OT  - Kawasaki disease
OT  - bioinformatics analysis
OT  - intravenous immunoglobulin
OT  - mechanism of action
COIS- The authors declare that they have no competing interests.
EDAT- 2021/06/01 06:00
MHDA- 2021/06/01 06:01
PMCR- 2021/05/19
CRDT- 2021/05/31 06:10
PHST- 2020/10/23 00:00 [received]
PHST- 2021/03/11 00:00 [accepted]
PHST- 2021/05/31 06:10 [entrez]
PHST- 2021/06/01 06:00 [pubmed]
PHST- 2021/06/01 06:01 [medline]
PHST- 2021/05/19 00:00 [pmc-release]
AID - ETM-0-0-10216 [pii]
AID - 10.3892/etm.2021.10216 [doi]
PST - ppublish
SO  - Exp Ther Med. 2021 Jul;22(1):784. doi: 10.3892/etm.2021.10216. Epub 2021 May 19.