PMID- 34055102
OWN - NLM
STAT- MEDLINE
DCOM- 20211206
LR  - 20220423
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2021
DP  - 2021
TI  - HDL-C/apoA-I Ratio Is Associated with the Severity of Coronary Artery Stenosis in 
      Diabetic Patients with Acute Coronary Syndrome.
PG  - 6689056
LID - 10.1155/2021/6689056 [doi]
LID - 6689056
AB  - BACKGROUND: Emerging evidence demonstrates that the lipid metabolism in acute 
      coronary syndrome (ACS) patients with type 2 diabetes mellitus (T2DM) differs 
      from nondiabetic patients. However, the distinct lipid profiles and their 
      relationships with the severity of coronary artery stenosis and prognosis in 
      patients with T2DM remain elusive. METHOD AND RESULT: This single-center, 
      prospective cohort study enrolled 468 patients diagnosed with ACS undergoing 
      coronary angiography, consisting of 314 non-DM and 154 DM patients. The 
      HDL-C/apoA-I ratio was significantly higher in DM patients with a multivessel (>/=3 
      affected vessels) lesion than a single-vessel (1-2 affected vessels) lesion. 
      Regression analyses showed that the HDL-C/apoA-I ratio was positively correlated 
      to the number of stenotic coronary arteries in DM patients but not non-DM 
      patients. However, Kaplan-Meier survival analysis revealed no significant 
      difference in the major adverse cardiovascular event rate regarding different 
      HDL-C/apoA-I levels in DM or non-DM ACS patients at the end of the 2-year 
      follow-up. CONCLUSION: A higher HDL-C/apoA-I ratio is associated with increased 
      severity of coronary artery stenosis in DM patients with ACS but not with the 
      rate of major adverse cardiovascular events at the end of the 2-year follow-up.
CI  - Copyright (c) 2021 Lizhe Sun et al.
FAU - Sun, Lizhe
AU  - Sun L
AD  - Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an 
      Jiaotong University, Xi'an, Shaanxi, China.
FAU - Guo, Manyun
AU  - Guo M
AD  - Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an 
      Jiaotong University, Xi'an, Shaanxi, China.
FAU - Xu, Chenbo
AU  - Xu C
AD  - Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an 
      Jiaotong University, Xi'an, Shaanxi, China.
FAU - Qiao, Xiangrui
AU  - Qiao X
AD  - Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an 
      Jiaotong University, Xi'an, Shaanxi, China.
FAU - Hua, Yiming
AU  - Hua Y
AD  - Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an 
      Jiaotong University, Xi'an, Shaanxi, China.
FAU - Tuerhongjiang, Gulinigaer
AU  - Tuerhongjiang G
AD  - Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an 
      Jiaotong University, Xi'an, Shaanxi, China.
FAU - Lou, Bowen
AU  - Lou B
AD  - Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an 
      Jiaotong University, Xi'an, Shaanxi, China.
FAU - Li, Ruifeng
AU  - Li R
AD  - Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an 
      Jiaotong University, Xi'an, Shaanxi, China.
FAU - Bai, Xiaofang
AU  - Bai X
AD  - Department of Ultrasound Imaging, First Affiliated Hospital of Medical College, 
      Xi'an Jiaotong University, Xi'an, Shaanxi, China.
FAU - Zhou, Juan
AU  - Zhou J
AD  - Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an 
      Jiaotong University, Xi'an, Shaanxi, China.
AD  - Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong 
      University, Ministry of Education, Xi'an, Shaanxi, China.
AD  - Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, Shaanxi, 
      China.
FAU - Wu, Yue
AU  - Wu Y
AD  - Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an 
      Jiaotong University, Xi'an, Shaanxi, China.
FAU - She, Jianqing
AU  - She J
AUID- ORCID: 0000-0003-0301-7943
AD  - Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an 
      Jiaotong University, Xi'an, Shaanxi, China.
FAU - Yuan, Zuyi
AU  - Yuan Z
AUID- ORCID: 0000-0002-7341-6889
AD  - Department of Cardiovascular Medicine, The First Affiliated Hospital, Xi'an 
      Jiaotong University, Xi'an, Shaanxi, China.
AD  - Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong 
      University, Ministry of Education, Xi'an, Shaanxi, China.
AD  - Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, Shaanxi, 
      China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20210518
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (APOA1 protein, human)
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, HDL)
SB  - IM
MH  - Acute Coronary Syndrome/blood/*diagnosis/etiology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Apolipoprotein A-I/*blood
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cholesterol, HDL/*blood
MH  - Coronary Stenosis/blood/*diagnosis/etiology
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - *Patient Acuity
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
PMC - PMC8149224
COIS- There is no conflict of interest regarding the publication of this article.
EDAT- 2021/06/01 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/05/18
CRDT- 2021/05/31 06:10
PHST- 2020/11/13 00:00 [received]
PHST- 2021/03/30 00:00 [revised]
PHST- 2021/04/15 00:00 [accepted]
PHST- 2021/05/31 06:10 [entrez]
PHST- 2021/06/01 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/05/18 00:00 [pmc-release]
AID - 10.1155/2021/6689056 [doi]
PST - epublish
SO  - Dis Markers. 2021 May 18;2021:6689056. doi: 10.1155/2021/6689056. eCollection 
      2021.