PMID- 34055407
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220423
IS  - 2090-1305 (Print)
IS  - 2090-1313 (Electronic)
IS  - 2090-1305 (Linking)
VI  - 2021
DP  - 2021
TI  - Monitoring Unfractionated Heparin in Adult Patients Undergoing Extracorporeal 
      Membrane Oxygenation (ECMO): ACT, APTT, or ANTI-XA?
PG  - 5579936
LID - 10.1155/2021/5579936 [doi]
LID - 5579936
AB  - BACKGROUND: During ECMO, anticoagulants, in particular, unfractionated heparin 
      (UFH), are commonly used and monitored by laboratory tests, including ACT, APTT, 
      and anti-Xa level. METHOD: A single-center retrospective observational study was 
      conducted on adult patients undergoing ECMO between January 2019 and January 2020 
      at a tertiary hospital. The correlations between ACT, APTT, anti-Xa, 
      antithrombin, and UFH dose were assessed. RESULTS: 129 sets of measurements from 
      37 patients were obtained including ACT, APTT, anti-Xa, antithrombin, and UFH 
      dose measured simultaneously. 102 out of 129 sets of values were interpreted as 
      antithrombin deficiencies. The correlation coefficient between APTT and anti-Xa; 
      ACT and anti-Xa are 0.72 and 0.33, respectively, p < 0.001. The patients with 
      normal antithrombin levels exhibited a significant correlation between APTT and 
      anti-Xa (r = 0.80, p < 0.001). ACT, on the other hand, was poorly correlated with 
      UFH dose, whether there is AT deficiency or not. Anti-Xa and APTT are only 
      moderately correlated with UFH dose in the group without antithrombin deficiency, 
      with correlation coefficients of 0.62 and 0.57, respectively, p < 0.05. 
      CONCLUSION: APTT value is strongly correlated with anti-Xa value, particularly in 
      patients with normal antithrombin levels. However, the ACT value was poorly 
      correlated with anti-Xa and not with the UFH dose. In groups without antithrombin 
      deficiency, APTT and anti-Xa values only moderately correlated with UFH dose.
CI  - Copyright (c) 2021 Tung Phi Nguyen et al.
FAU - Nguyen, Tung Phi
AU  - Nguyen TP
AUID- ORCID: 0000-0003-3795-2577
AD  - Department of Intensive Care, Ho Chi Minh City University of Medicine and 
      Pharmacy, Ho Chi Minh City, Vietnam.
AD  - Intensive Care Unit, Vinmec International Hospital, Hanoi, Vietnam.
FAU - Phan, Xuan Thi
AU  - Phan XT
AD  - Department of Intensive Care, Ho Chi Minh City University of Medicine and 
      Pharmacy, Ho Chi Minh City, Vietnam.
AD  - Intensive Care Unit, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
FAU - Huynh, Dai Quang
AU  - Huynh DQ
AD  - Department of Intensive Care, Ho Chi Minh City University of Medicine and 
      Pharmacy, Ho Chi Minh City, Vietnam.
FAU - Viet Truong, Ha Thi
AU  - Viet Truong HT
AD  - Intensive Care Unit, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
FAU - Hai Le, Yen Nguyen
AU  - Hai Le YN
AD  - Intensive Care Unit, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
FAU - Nguyen, Tuan Manh
AU  - Nguyen TM
AD  - Intensive Care Unit, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
FAU - Minh Du, Quan Quoc
AU  - Minh Du QQ
AD  - Department of Intensive Care, Ho Chi Minh City University of Medicine and 
      Pharmacy, Ho Chi Minh City, Vietnam.
AD  - Intensive Care Unit, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
FAU - Le, Thao Phuong
AU  - Le TP
AD  - Department of Intensive Care, Ho Chi Minh City University of Medicine and 
      Pharmacy, Ho Chi Minh City, Vietnam.
FAU - Truong, Hai Ngoc
AU  - Truong HN
AD  - Department of Intensive Care, Ho Chi Minh City University of Medicine and 
      Pharmacy, Ho Chi Minh City, Vietnam.
FAU - Ho, Thi Thi
AU  - Ho TT
AD  - Intensive Care Unit, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
FAU - Ngoc Pham, Thao Thi
AU  - Ngoc Pham TT
AD  - Department of Intensive Care, Ho Chi Minh City University of Medicine and 
      Pharmacy, Ho Chi Minh City, Vietnam.
AD  - Intensive Care Unit, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
LA  - eng
PT  - Journal Article
DEP - 20210503
PL  - Egypt
TA  - Crit Care Res Pract
JT  - Critical care research and practice
JID - 101539357
PMC - PMC8112950
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2021/06/01 06:00
MHDA- 2021/06/01 06:01
PMCR- 2021/05/03
CRDT- 2021/05/31 06:14
PHST- 2021/01/28 00:00 [received]
PHST- 2021/04/20 00:00 [accepted]
PHST- 2021/05/31 06:14 [entrez]
PHST- 2021/06/01 06:00 [pubmed]
PHST- 2021/06/01 06:01 [medline]
PHST- 2021/05/03 00:00 [pmc-release]
AID - 10.1155/2021/5579936 [doi]
PST - epublish
SO  - Crit Care Res Pract. 2021 May 3;2021:5579936. doi: 10.1155/2021/5579936. 
      eCollection 2021.