PMID- 34057459
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20220314
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Linking)
VI  - 61
IP  - 3
DP  - 2022 Mar 2
TI  - Interventricular systolic asynchrony predicts prognosis in patients with systemic 
      sclerosis-associated pulmonary arterial hypertension.
PG  - 983-991
LID - 10.1093/rheumatology/keab465 [doi]
AB  - OBJECTIVE: Pulmonary arterial hypertension (PAH) is a serious complication of SSc 
      with high mortality. Interventricular systolic asynchrony (IVSA) is observed in 
      PAH patients, but the effect of IVSA and its association with long-term mortality 
      and clinical events in SSc-associated PAH are unclear. This study aimed to 
      investigate the impact of IVSA on the prognosis of SSc-associated PAH. METHODS: 
      Between March 2010 and July 2018, a total of 60 consecutive patients with 
      SSc-associated PAH were enrolled. The end point was a composite of all-cause 
      mortality and clinical worsening. Asynchrony was assessed by colour-coded tissue 
      Doppler imaging (TDI) echocardiography. The myocardial sustained systole curves 
      (Sm) of the basal portion of the right ventricular (RV) free wall and left 
      ventricular (LV) lateral wall were obtained. IVSA was defined as the time 
      difference from the onset of the QRS complex to the end of Sm between LV and RV. 
      RESULTS: Patients with greater IVSA time differences presented with advanced 
      pulmonary vascular resistance (PVR). The IVSA time difference was an independent 
      predictive factor (Hazard Ratio (HR) = 1.018, 95% CI: 1.005, 1.031, P =0.005) for 
      the composite end point and was significantly associated with PVR (r = 0.399, 
      R2=0.092, P =0.002). Kaplan-Meier survival curves showed that patients with 
      greater IVSA had worse prognoses (log-rank P =0.001). CONCLUSION: In conclusion, 
      IVSA analysed by colour-coded TDI echocardiography provided added value as a 
      noninvasive, easy-to-use approach for assessing the prognosis of patients with 
      SSc-associated PAH. A significant IVSA time difference identifies the subgroup of 
      patients at high risk of a poor prognosis.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      British Society for Rheumatology. All rights reserved. For permissions, please 
      email: journals.permissions@oup.com.
FAU - Lai, Jinzhi
AU  - Lai J
AD  - Department of Cardiology.
FAU - Guo, Xiaoxiao
AU  - Guo X
AD  - Department of Cardiology.
FAU - Zhao, Jiuliang
AU  - Zhao J
AD  - Department of Rheumatology, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, Beijing, China.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Rheumatology, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, Beijing, China.
FAU - Tian, Zhuang
AU  - Tian Z
AD  - Department of Cardiology.
FAU - Wang, Qian
AU  - Wang Q
AD  - Department of Rheumatology, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, Beijing, China.
FAU - Li, Mengtao
AU  - Li M
AUID- ORCID: 0000-0003-4252-2889
AD  - Department of Rheumatology, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, Beijing, China.
FAU - Fang, Quan
AU  - Fang Q
AD  - Department of Cardiology.
FAU - Fang, Ligang
AU  - Fang L
AD  - Department of Cardiology.
FAU - Liu, Yongtai
AU  - Liu Y
AD  - Department of Cardiology.
FAU - Zeng, Xiaofeng
AU  - Zeng X
AD  - Department of Rheumatology, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Echocardiography, Doppler, Color
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Hypertension, Pulmonary/*mortality
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Prognosis
MH  - Scleroderma, Systemic/*mortality
MH  - Systole/*physiology
MH  - Vascular Resistance/physiology
OTO - NOTNLM
OT  - echocardiography
OT  - interventricular systolic asynchrony
OT  - pulmonary arterial hypertension
OT  - systemic sclerosis
EDAT- 2021/06/01 06:00
MHDA- 2022/03/15 06:00
CRDT- 2021/05/31 12:51
PHST- 2021/01/12 00:00 [received]
PHST- 2021/05/19 00:00 [revised]
PHST- 2021/06/01 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2021/05/31 12:51 [entrez]
AID - 6290000 [pii]
AID - 10.1093/rheumatology/keab465 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2022 Mar 2;61(3):983-991. doi: 
      10.1093/rheumatology/keab465.