PMID- 34058235
OWN - NLM
STAT- MEDLINE
DCOM- 20211004
LR  - 20211004
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 153
DP  - 2021 Jul
TI  - Probiotics as a biological detoxification tool of food chemical contamination: A 
      review.
PG  - 112306
LID - S0278-6915(21)00339-2 [pii]
LID - 10.1016/j.fct.2021.112306 [doi]
AB  - Nowadays, people are exposed to diverse environmental and chemical pollutants 
      produced by industry and agriculture. Food contaminations such as persistent 
      organic pollutants (POPs), heavy metals, and mycotoxins are a serious concern for 
      global food safety with economic and public health implications especially in the 
      newly industrialized countries (NIC). Mounting evidence indicates that chronic 
      exposure to food contaminants referred to as xenobiotics exert a negative effect 
      on human health such as inflammation, oxidative stress, and intestinal disorders 
      linked with perturbation of the composition and metabolic profile of the gut 
      microflora. Although the physicochemical technologies for food decontamination 
      are utilized in many cases but require adequate conditions which are often not 
      feasible to be met in many industrial sectors. At present, one promising approach 
      to reduce the risk related to the presence of xenobiotics in foodstuffs is a 
      biological detoxification done by probiotic strains and their enzymes. Many 
      studies confirmed that probiotics are an effective, feasible, and inexpensive 
      tool for preventing xenobiotic-induced dysbiosis and alleviating their toxicity. 
      This review aims to summarize the current knowledge of the direct mechanisms by 
      which probiotics can influence the detoxification of xenobiotics. Moreover, 
      probiotic-xenobiotic interactions with the gut microbiota and the host response 
      were also discussed.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Srednicka, Paulina
AU  - Srednicka P
AD  - Laboratory of Biotechnology and Molecular Engineering, Department of 
      Microbiology, Prof. Waclaw Dabrowski Institute of Agricultural and Food 
      Biotechnology, State Research Institute, Rakowiecka 36 Street, Warsaw, Poland.
FAU - Juszczuk-Kubiak, Edyta
AU  - Juszczuk-Kubiak E
AD  - Laboratory of Biotechnology and Molecular Engineering, Department of 
      Microbiology, Prof. Waclaw Dabrowski Institute of Agricultural and Food 
      Biotechnology, State Research Institute, Rakowiecka 36 Street, Warsaw, Poland. 
      Electronic address: edyta.juszczuk-kubiak@ibprs.pl.
FAU - Wojcicki, Michal
AU  - Wojcicki M
AD  - Laboratory of Biotechnology and Molecular Engineering, Department of 
      Microbiology, Prof. Waclaw Dabrowski Institute of Agricultural and Food 
      Biotechnology, State Research Institute, Rakowiecka 36 Street, Warsaw, Poland.
FAU - Akimowicz, Monika
AU  - Akimowicz M
AD  - Laboratory of Biotechnology and Molecular Engineering, Department of 
      Microbiology, Prof. Waclaw Dabrowski Institute of Agricultural and Food 
      Biotechnology, State Research Institute, Rakowiecka 36 Street, Warsaw, Poland.
FAU - Roszko, Marek L
AU  - Roszko ML
AD  - Department of Food Safety and Chemical Analysis, Prof. Waclaw Dabrowski Institute 
      of Agricultural and Food Biotechnology - State Research Institute, Rakowiecka 36 
      Street, Warsaw, Poland. Electronic address: marek.roszko@ibprs.pl.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210528
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Xenobiotics)
SB  - IM
MH  - Animals
MH  - Dysbiosis/chemically induced/diet therapy
MH  - Food Contamination/*prevention & control
MH  - Gastrointestinal Microbiome/physiology
MH  - Gene Expression/physiology
MH  - Humans
MH  - Probiotics/*metabolism/therapeutic use
MH  - Xenobiotics/*metabolism/toxicity
OTO - NOTNLM
OT  - Food contaminants
OT  - Gut microbiota
OT  - Probiotic-xenobiotic-host axis
OT  - Probiotics
OT  - Xenobiotic metabolism
EDAT- 2021/06/01 06:00
MHDA- 2021/10/05 06:00
CRDT- 2021/05/31 20:11
PHST- 2021/03/26 00:00 [received]
PHST- 2021/05/17 00:00 [revised]
PHST- 2021/05/24 00:00 [accepted]
PHST- 2021/06/01 06:00 [pubmed]
PHST- 2021/10/05 06:00 [medline]
PHST- 2021/05/31 20:11 [entrez]
AID - S0278-6915(21)00339-2 [pii]
AID - 10.1016/j.fct.2021.112306 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2021 Jul;153:112306. doi: 10.1016/j.fct.2021.112306. Epub 2021 
      May 28.