PMID- 34058267
OWN - NLM
STAT- MEDLINE
DCOM- 20220209
LR  - 20220209
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 411
DP  - 2021 Aug 6
TI  - Effects of enriched environment on depression and anxiety-like behavior induced 
      by early life stress: A comparison between different periods.
PG  - 113389
LID - S0166-4328(21)00277-1 [pii]
LID - 10.1016/j.bbr.2021.113389 [doi]
AB  - BACKGROUND: Brain development is a prolonged process and it is sensitive to the 
      environment during critical periods. Stress in early life is believed to increase 
      vulnerability to depression, while enriched environment (EE) has beneficial 
      effects on neural plasticity and depression. In this study, we compared the 
      therapeutic effect of EE during different periods on early life stress-induced 
      depression, and investigated the role of brain-derived neurotrophic factor (BDNF) 
      and protein kinase B (AKT) on the effect of EE. Plasma corticosterone level was 
      also detected to evaluate the reactivity of hypothalamic-pituitary-adrenal axis. 
      METHODS: C57BL/6 mice were subjected to a 4-h maternal separation (MS) procedure 
      during postnatal days 2-21. After this separation, the mice were assigned to 
      standard environment groups (SE), EE in the early period groups (3-8 weeks, EEE) 
      and EE in the adult groups (8-13 weeks, EEA). Depression and anxiety behavior 
      were evaluated at 14-weeks of age. The plasma corticosterone was quantified 
      utilizing enzyme-linked immunosorbent assay. Hippocampus BDNF and AKT/p-AKT were 
      detected using Western blotting. RESULTS: The results showed that MS increased 
      depression and anxiety level, while EE in both intervention periods alleviated 
      the symptoms of depression and anxiety. The EEE group showed better effects in 
      terms of anhedonia and anxiety than the EEA group. The difference in despair 
      behavior between the EEE and EEA groups was not significant. MS increased plasma 
      corticosterone level, while EE decreased corticosterone level in both 
      intervention periods. EE increased BDNF and p-AKT expression in the hippocampus, 
      with stronger effects in the EEE group. CONCLUSION: EE during the early 
      development period was more effective in alleviating depression and anxiety 
      induced by early life stress. BDNF and AKT may play a significant role in the 
      effect of EE, and further research is needed to explore the detailed 
      neurobiological mechanisms.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Huang, Hongfei
AU  - Huang H
AD  - Department of Psychiatry, The First Hospital of China Medical University, 
      Shenyang, Liaoning, 110001, China; Department of Psychiatry, General Hospital of 
      Northern Theater Command, Shenyang, Liaoning, 110001, China.
FAU - Wang, Qi
AU  - Wang Q
AD  - Department of Psychiatry, General Hospital of Northern Theater Command, Shenyang, 
      Liaoning, 110001, China.
FAU - Guan, Xiaofeng
AU  - Guan X
AD  - Department of Psychiatry, The First Hospital of China Medical University, 
      Shenyang, Liaoning, 110001, China.
FAU - Zhang, Xia
AU  - Zhang X
AD  - Department of Psychiatry, The First Hospital of China Medical University, 
      Shenyang, Liaoning, 110001, China.
FAU - Zhang, Yihan
AU  - Zhang Y
AD  - Department of Psychiatry, The First Hospital of China Medical University, 
      Shenyang, Liaoning, 110001, China.
FAU - Cao, Jinlong
AU  - Cao J
AD  - Department of Psychiatry, The Fourth Hospital of Haining People, Jiaxing, 
      Zhejiang, China.
FAU - Li, Xiaobai
AU  - Li X
AD  - Department of Psychiatry, The First Hospital of China Medical University, 
      Shenyang, Liaoning, 110001, China. Electronic address: xbli@cmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210528
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Anxiety/*etiology/physiopathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Corticosterone/analysis/blood
MH  - Depression/*etiology/physiopathology
MH  - *Environment
MH  - Female
MH  - Hypothalamo-Hypophyseal System/metabolism
MH  - Male
MH  - Maternal Deprivation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuronal Plasticity/physiology
MH  - Pituitary-Adrenal System/metabolism
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Stress, Psychological/metabolism/physiopathology
OTO - NOTNLM
OT  - Brain development
OT  - Depression
OT  - Early life stress
OT  - Enriched environment
EDAT- 2021/06/01 06:00
MHDA- 2022/02/10 06:00
CRDT- 2021/05/31 20:12
PHST- 2020/12/29 00:00 [received]
PHST- 2021/05/24 00:00 [revised]
PHST- 2021/05/25 00:00 [accepted]
PHST- 2021/06/01 06:00 [pubmed]
PHST- 2022/02/10 06:00 [medline]
PHST- 2021/05/31 20:12 [entrez]
AID - S0166-4328(21)00277-1 [pii]
AID - 10.1016/j.bbr.2021.113389 [doi]
PST - ppublish
SO  - Behav Brain Res. 2021 Aug 6;411:113389. doi: 10.1016/j.bbr.2021.113389. Epub 2021 
      May 28.