PMID- 34059017 OWN - NLM STAT- MEDLINE DCOM- 20210609 LR - 20210609 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 21 IP - 1 DP - 2021 May 31 TI - Hematological indices and abnormalities among patients with uncomplicated falciparum malaria in Kosti city of the White Nile state, Sudan: a comparative study. PG - 507 LID - 10.1186/s12879-021-06228-y [doi] LID - 507 AB - BACKGROUND: Hematological abnormalities are common features in falciparum malaria but vary among different populations across countries. Therefore, we compared hematological indices and abnormalities between Plasmodium falciparum-infected patients and malaria-negative subjects in Kosti city of the White Nile State, Sudan. METHODS: A comparative, cross-sectional study was conducted at the Clinical Laboratory Unit of Kosti Teaching Hospital from June to December 2018. A total of 392 participants (192 P. falciparum-infected patients and 200 malaria-negative subjects) were recruited in the study. Hematological indices of hemoglobin (Hb), red blood cells (RBCs), white blood cells (WBCs) and platelets were measured, and their median values were statistically compared. RESULTS: The majority of P. falciparum-infected patients (67.6%) showed a low-level parasitemia. The median values of Hb concentration, RBC count, mean corpuscular volume (MCV), mean corpuscular Hb (MCH) and mean corpuscular Hb concentration (MCHC) were significantly lower in P. falciparum-infected patients, while the median red cell distribution width (RDW) was significantly higher in the patients compared to malaria-negative subjects. Anemia, low MCV, low MCH, low MCHC and high RDW were significantly associated with falciparum malaria, but parasitemia level was not significantly associated with anemia severity. The median total WBC count was non-significantly higher in P. falciparum-infected patients, with neutropenia being significantly associated with falciparum malaria. The median platelet count was significantly lower in P. falciparum-infected patients, with thrombocytopenia being significantly associated with falciparum malaria. CONCLUSIONS: Falciparum malaria among patients in Kosti city of the White Nile State, Sudan is predominantly of low-level parasitemia. It is significantly associated with anemia, low MCV, low MCH, low MCHC, high RDW, thrombocytopenia and neutropenia. However, parasitemia level is not a significant predictor of anemia severity. On the other hand, leucopenia is not useful to predict falciparum malaria. Further large-scale studies in community and healthcare settings and inclusion of patients with complicated or severe malaria and those with high parasite densities are recommended. FAU - Elkhalifa, Ahmed M E AU - Elkhalifa AME AD - Department of Public Health, College of Health Sciences Saudi Electronic University, Riyadh, Kingdom of Saudi Arabia. AD - Department of Hematology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan. FAU - Abdul-Ghani, Rashad AU - Abdul-Ghani R AUID- ORCID: 0000-0001-7181-1108 AD - Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen. rashadqb@yahoo.com. AD - Tropical Disease Research Center, Faculty of Medicine and Health Sciences, University, of Science and Technology, Sana'a, Yemen. rashadqb@yahoo.com. FAU - Tamomh, Abdelhakam G AU - Tamomh AG AD - Department of Parasitology and Medical Entomology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan. FAU - Eltaher, Nur Eldin AU - Eltaher NE AD - Department of Public Health, Faculty of Public and Environmental Health, University of El Imam El Mahdi, Kosti, Sudan. FAU - Ali, Nada Y AU - Ali NY AD - Department of Hematology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan. FAU - Ali, Moataz M AU - Ali MM AD - Department of Pathology, Faculty of Medicine, University of El Imam El Mahdi, Kosti, Sudan. AD - Department of Pathology, Faculty of Medicine, Albaha University, Albaha, Kingdom of Saudi Arabia. FAU - Bazie, Elsharif A AU - Bazie EA AD - Department of Pediatrics, Faculty of Medicine, University of El Imam El Mahdi, Kosti, Sudan. FAU - KhirAlla, Aboagla AU - KhirAlla A AD - Department of Hematology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan. FAU - DfaAlla, Fatin A AU - DfaAlla FA AD - Department of Hematology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan. FAU - Alhasan, Omnia A M AU - Alhasan OAM AD - Department of Hematology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan. LA - eng PT - Comparative Study PT - Journal Article DEP - 20210531 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - Adolescent MH - Adult MH - Anemia/blood/parasitology MH - Child MH - Child, Preschool MH - Cross-Sectional Studies MH - Female MH - Hematologic Tests MH - Humans MH - Infant MH - Leukopenia/blood/parasitology MH - Malaria, Falciparum/*blood/parasitology MH - Male MH - Middle Aged MH - Parasitemia/blood/parasitology MH - Plasmodium falciparum MH - Thrombocytopenia/blood/parasitology MH - Young Adult PMC - PMC8166086 OTO - NOTNLM OT - Anemia OT - Falciparum malaria OT - Hematological indices OT - MCH OT - MCHC OT - MCV OT - Neutropenia OT - RDW OT - Sudan OT - Thrombocytopenia COIS- The authors declare that they have no competing interests. EDAT- 2021/06/02 06:00 MHDA- 2021/06/10 06:00 PMCR- 2021/05/31 CRDT- 2021/06/01 05:38 PHST- 2021/02/18 00:00 [received] PHST- 2021/05/24 00:00 [accepted] PHST- 2021/06/01 05:38 [entrez] PHST- 2021/06/02 06:00 [pubmed] PHST- 2021/06/10 06:00 [medline] PHST- 2021/05/31 00:00 [pmc-release] AID - 10.1186/s12879-021-06228-y [pii] AID - 6228 [pii] AID - 10.1186/s12879-021-06228-y [doi] PST - epublish SO - BMC Infect Dis. 2021 May 31;21(1):507. doi: 10.1186/s12879-021-06228-y.