PMID- 34059041
OWN - NLM
STAT- MEDLINE
DCOM- 20211206
LR  - 20211214
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 21
IP  - 1
DP  - 2021 May 31
TI  - Habitual intake of dietary L-arginine in relation to risk of type 2 diabetes: a 
      prospective study.
PG  - 113
LID - 10.1186/s12902-021-00774-x [doi]
LID - 113
AB  - BACKGROUND: There are insufficient data in case of the potential association of 
      habitual dietary L-arginine and the risk of type 2 diabetes mellitus (T2DM) 
      incidence. Here we aimed to examine the potential effect of dietary L-arginine on 
      the T2DM incidence. METHODS: For this cohort study, 2139 T2DM-free adults from 
      the participations of Tehran Lipid and Glucose Study (TLGS) were recruited. 
      Follow up period was approximately 5.8 years. Daily intakes of protein and 
      L-arginine were estimated using a validated food frequency questionnaire with 168 
      food item. Hazard Ratios (HRs) and 95% confidence intervals (CIs), adjusted for 
      sex, age, smoking, diabetes risk score, physical activity levels, and total 
      energy intakes as well as carbohydrate, fiber, fats and lysine, were calculated 
      for L-arginine as both absolute intake and its ratio from total protein. RESULTS: 
      Mean (+/-SD) age of the participants was 38.9 (+/-12.6) years and 54.6% were women. 
      Mean (+/-SD) intake of dietary protein and L-arginine was 77.2 (+/-22.4) and 4.05 
      (+/-1.50) g/d, respectively. An increased risk of T2DM (HR = 2.71, 95% 
      CI = 1.20-6.09) was observed among participants with higher intakes of L-arginine 
      (median intake of > 5.4 vs. 2.69 g/d). Total protein intake and the ratio of 
      L-arginine to total protein intakes were not related to incidence of T2DM in both 
      crude and adjusted models. CONCLUSION: We found that higher dietary L-arginine 
      levels may increase risk of T2DM and it may have an independent role in T2DM 
      development.
FAU - Mirmiran, Parvin
AU  - Mirmiran P
AD  - Nutrition and Endocrine Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, 
      No. 24, Sahid-Erabi St, Yemen St, Chamran Exp, Tehran, Iran.
FAU - Bahadoran, Zahra
AU  - Bahadoran Z
AD  - Nutrition and Endocrine Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, 
      No. 24, Sahid-Erabi St, Yemen St, Chamran Exp, Tehran, Iran. 
      zahrabahadoran@yahoo.com.
FAU - Gaeini, Zahra
AU  - Gaeini Z
AD  - Nutrition and Endocrine Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, 
      No. 24, Sahid-Erabi St, Yemen St, Chamran Exp, Tehran, Iran.
FAU - Azizi, Fereidoun
AU  - Azizi F
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20210531
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Adult
MH  - Arginine/administration & dosage/*adverse effects
MH  - Diabetes Mellitus, Type 2/*epidemiology/etiology/pathology
MH  - *Diet
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Iran/epidemiology
MH  - Male
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
PMC - PMC8165802
OTO - NOTNLM
OT  - Dietary protein
OT  - L-arginine
OT  - Type 2 diabetes
COIS- The authors declare that they have no competing of interests. Dr. Zahra Bahadoran 
      is a member of the editorial board of BMC Endocrine Disorders.
EDAT- 2021/06/02 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/05/31
CRDT- 2021/06/01 05:40
PHST- 2020/07/25 00:00 [received]
PHST- 2021/05/20 00:00 [accepted]
PHST- 2021/06/01 05:40 [entrez]
PHST- 2021/06/02 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/05/31 00:00 [pmc-release]
AID - 10.1186/s12902-021-00774-x [pii]
AID - 774 [pii]
AID - 10.1186/s12902-021-00774-x [doi]
PST - epublish
SO  - BMC Endocr Disord. 2021 May 31;21(1):113. doi: 10.1186/s12902-021-00774-x.