PMID- 34059085
OWN - NLM
STAT- MEDLINE
DCOM- 20211126
LR  - 20211126
IS  - 1546-0096 (Electronic)
IS  - 1546-0096 (Linking)
VI  - 19
IP  - 1
DP  - 2021 May 31
TI  - The "Intermediate" CD14 + CD16 + monocyte subpopulation plays a role in IVIG 
      responsiveness of children with Kawasaki disease.
PG  - 76
LID - 10.1186/s12969-021-00573-7 [doi]
LID - 76
AB  - BACKGROUND: Kawasaki disease (KD) is an acute, self-limited febrile illness of 
      unknown cause. Intravenous immunoglobulin (IVIG)-resistance are related to 
      greater risk for permanent cardiac complications. We aimed to determine the 
      correlation between monocytes and the phenotype of KD in relation to IVIG 
      responsiveness in children. MATERIALS AND METHODS: The study cohort included 62 
      patients who were diagnosed with KD, 20 non febrile healthy controls (NFC), and 
      15 other febrile controls (OFC). In all enrolled patients, blood was taken at 
      least 4 times and laboratory tests were performed. In addition, subtypes of 
      monocytes were characterized via flow cytometry. RESULTS: The numbers of 
      intermediate monocytes were significantly lower in IVIG-resistant group compared 
      to IVIG-responsive group before IVIG infusion (p < 0.0001). After infusion, 
      intermediate monocytes decreased in the responsive group, while a trend of 
      increase was observed in the resistant group. Only intermediate monocytes were 
      significant in logistic regression with adjusted OR of 0.001 and p value of 0.03. 
      CONCLUSIONS: CD14 + CD16 + intermediate monocyte may play an important role in 
      IVIG responsiveness among KD children. Low starting levels of intermediate 
      monocytes, followed by a dramatic increase post-IVIG infusion during acute phase 
      of KD are associated with IVIG-resistance. Functional studies on intermediate 
      monocyte may help to reveal the pathophysiology.
FAU - Kim, Yi Seul
AU  - Kim YS
AD  - Department of Pediatric, Chonnam National University Children's Hospital, 42 
      Jaebong ro, Gwangju, South Korea.
AD  - Department of Pediatrics, Ewha Womans University College of Medicine, Seoul, 
      South Korea.
FAU - Yang, Hyun Jin
AU  - Yang HJ
AD  - Chonnam National University Medical School, 42 Jaebong ro, Gwangju, South Korea.
FAU - Kee, Seung-Jung
AU  - Kee SJ
AD  - Chonnam National University Medical School, 42 Jaebong ro, Gwangju, South Korea.
AD  - Department of Laboratory Medicine, Chonnam National University Hwasun Hospital, 
      Hwasun, South Korea.
FAU - Choi, Insu
AU  - Choi I
AD  - Department of Pediatric, Chonnam National University Children's Hospital, 42 
      Jaebong ro, Gwangju, South Korea.
FAU - Ha, Kisoo
AU  - Ha K
AD  - Department of Pediatrics, Korea University Guro Hospital, Korea University 
      College of Medicine, Seoul, Korea.
FAU - Ki, Katrina K
AU  - Ki KK
AD  - Critical Care Research Group,, The Prince Charles Hospital, Queensland, 
      Chermside, Australia.
AD  - Faculty of Medicine, The University of Queensland, St. Lucia, Queensland, 
      Australia.
FAU - Jeong, In Seok
AU  - Jeong IS
AD  - Chonnam National University Medical School, 42 Jaebong ro, Gwangju, South Korea. 
      Isjeong1201@gmail.com.
AD  - Deparment of Cardiothoracic Surgery, Chonnam National University Hospital and 
      Medical School, 42 Jaebong ro, Gwangju, South Korea. Isjeong1201@gmail.com.
FAU - Cho, Hwa Jin
AU  - Cho HJ
AUID- ORCID: 0000-0002-2458-8529
AD  - Department of Pediatric, Chonnam National University Children's Hospital, 42 
      Jaebong ro, Gwangju, South Korea. chhj98@gmail.com.
AD  - Chonnam National University Medical School, 42 Jaebong ro, Gwangju, South Korea. 
      chhj98@gmail.com.
LA  - eng
GR  - BCR120006/Biomedical institute of Chonnam National University Hospital/
PT  - Journal Article
DEP - 20210531
PL  - England
TA  - Pediatr Rheumatol Online J
JT  - Pediatric rheumatology online journal
JID - 101248897
RN  - 0 (Biomarkers, Pharmacological)
RN  - 0 (FCGR3B protein, human)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Biomarkers, Pharmacological/analysis
MH  - Child, Preschool
MH  - Female
MH  - Fever/blood/immunology
MH  - Flow Cytometry/methods
MH  - GPI-Linked Proteins/immunology
MH  - Humans
MH  - *Immunoglobulins, Intravenous/administration & dosage/immunology
MH  - Immunologic Factors/administration & dosage/immunology
MH  - Immunophenotyping/methods
MH  - Lipopolysaccharide Receptors/*immunology
MH  - Male
MH  - *Monocytes/immunology/pathology
MH  - *Mucocutaneous Lymph Node Syndrome/blood/diagnosis/immunology/therapy
MH  - Patient Acuity
MH  - Receptors, IgG/*immunology
MH  - Treatment Outcome
PMC - PMC8165978
OTO - NOTNLM
OT  - IVIG responsiveness
OT  - IVIG-resistant
OT  - Immunity
OT  - Intermediate monocyte
OT  - Kawasaki disease
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/06/02 06:00
MHDA- 2021/11/27 06:00
PMCR- 2021/05/31
CRDT- 2021/06/01 05:42
PHST- 2020/12/19 00:00 [received]
PHST- 2021/05/20 00:00 [accepted]
PHST- 2021/06/01 05:42 [entrez]
PHST- 2021/06/02 06:00 [pubmed]
PHST- 2021/11/27 06:00 [medline]
PHST- 2021/05/31 00:00 [pmc-release]
AID - 10.1186/s12969-021-00573-7 [pii]
AID - 573 [pii]
AID - 10.1186/s12969-021-00573-7 [doi]
PST - epublish
SO  - Pediatr Rheumatol Online J. 2021 May 31;19(1):76. doi: 
      10.1186/s12969-021-00573-7.