PMID- 34062073
OWN - NLM
STAT- MEDLINE
DCOM- 20220127
LR  - 20220216
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Print)
IS  - 0862-8408 (Linking)
VI  - 70
IP  - 4
DP  - 2021 Aug 31
TI  - Pathophysiological Characteristics Linking Type 2 Diabetes Mellitus and 
      Colorectal Neoplasia.
PG  - 509-522
AB  - A substantial body of literature has provided evidence that type 2 diabetes 
      mellitus (T2DM) and colorectal neoplasia share several common factors. Both 
      diseases are among the leading causes of death worldwide and have an increasing 
      incidence. In addition to usual risk factors such as sedentary lifestyle, 
      obesity, and family history, common pathophysiological mechanisms involved in the 
      development of these diseases have been identified. These include changes in 
      glucose metabolism associated with adipose tissue dysfunction including insulin 
      resistance resulting to hyperinsulinemia and chronic hyperglycemia. In addition 
      to altered glucose metabolism, abdominal obesity has been associated with 
      accented carcinogenesis with chronic subclinical inflammation. An increasing 
      number of studies have recently described the role of the gut microbiota in 
      metabolic diseases including T2DM and the development of colorectal cancer (CRC). 
      Due to the interconnectedness of different pathophysiological processes, it is 
      not entirely clear which factor is crucial in the development of carcinogenesis 
      in patients with T2DM. The aim of this work is to review the current knowledge on 
      the pathophysiological mechanisms of colorectal neoplasia development in 
      individuals with T2DM. Here, we review the potential pathophysiological processes 
      involved in the onset and progression of colorectal neoplasia in patients with 
      T2DM. Uncovering common pathophysiological characteristics is essential for 
      understanding the nature of these diseases and may lead to effective treatment 
      and prevention.
FAU - Grega, T
AU  - Grega T
AD  - Department of Internal Medicine, 1st Faculty of Medicine, Charles University, 
      Military University Hospital in Prague, Czech Republic. tomas.grega@uvn.cz.
FAU - Vojtechova, G
AU  - Vojtechova G
FAU - Gregova, M
AU  - Gregova M
FAU - Zavoral, M
AU  - Zavoral M
FAU - Suchanek, S
AU  - Suchanek S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210601
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
SB  - IM
MH  - Adiposity
MH  - Animals
MH  - Colorectal Neoplasms/epidemiology/microbiology/*physiopathology
MH  - Diabetes Mellitus, Type 2/epidemiology/microbiology/*physiopathology
MH  - Dysbiosis
MH  - Energy Metabolism
MH  - Gastrointestinal Microbiome
MH  - Humans
MH  - Hyperglycemia/epidemiology/physiopathology
MH  - Hyperinsulinism/epidemiology/physiopathology
MH  - Incidence
MH  - Insulin Resistance
MH  - Obesity/epidemiology/physiopathology
MH  - Risk Assessment
MH  - Risk Factors
PMC - PMC8820551
COIS- Conflict of Interest There is no conflict of interest.
EDAT- 2021/06/02 06:00
MHDA- 2022/01/28 06:00
PMCR- 2021/06/02
CRDT- 2021/06/01 20:08
PHST- 2021/06/02 06:00 [pubmed]
PHST- 2022/01/28 06:00 [medline]
PHST- 2021/06/01 20:08 [entrez]
PHST- 2021/06/02 00:00 [pmc-release]
AID - 934631 [pii]
AID - pr70_509 [pii]
AID - 10.33549/physiolres.934631 [doi]
PST - ppublish
SO  - Physiol Res. 2021 Aug 31;70(4):509-522. doi: 10.33549/physiolres.934631. Epub 
      2021 Jun 1.