PMID- 34062764
OWN - NLM
STAT- MEDLINE
DCOM- 20210922
LR  - 20211204
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 11
IP  - 5
DP  - 2021 May 1
TI  - mTOR Signaling in Metabolic Stress Adaptation.
LID - 10.3390/biom11050681 [doi]
LID - 681
AB  - The mechanistic target of rapamycin (mTOR) is a central regulator of cellular 
      homeostasis that integrates environmental and nutrient signals to control cell 
      growth and survival. Over the past two decades, extensive studies of mTOR have 
      implicated the importance of this protein complex in regulating a broad range of 
      metabolic functions, as well as its role in the progression of various human 
      diseases. Recently, mTOR has emerged as a key signaling molecule in regulating 
      animal entry into a hypometabolic state as a survival strategy in response to 
      environmental stress. Here, we review current knowledge of the role that mTOR 
      plays in contributing to natural hypometabolic states such as hibernation, 
      estivation, hypoxia/anoxia tolerance, and dauer diapause. Studies across a 
      diverse range of animal species reveal that mTOR exhibits unique regulatory 
      patterns in an environmental stressor-dependent manner. We discuss how key 
      signaling proteins within the mTOR signaling pathways are regulated in different 
      animal models of stress, and describe how each of these regulations uniquely 
      contribute to promoting animal survival in a hypometabolic state.
FAU - Wu, Cheng-Wei
AU  - Wu CW
AD  - Department of Veterinary Biomedical Sciences, Western College of Veterinary 
      Medicine, 52 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5B4, 
      Canada.
AD  - Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N 5B3, Canada.
FAU - Storey, Kenneth B
AU  - Storey KB
AD  - Institute of Biochemistry and Department of Biology, Carleton University, 1125 
      Colonel By Drive, Ottawa, ON K1S 5B6, Canada.
LA  - eng
GR  - 04486, 6793/Natural Sciences and Engineering Research Council (NSERC) of Canada/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210501
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adaptation, Physiological/physiology
MH  - Animals
MH  - Cell Cycle
MH  - Cell Proliferation
MH  - Diapause/physiology
MH  - Estivation/physiology
MH  - Hibernation/physiology
MH  - Humans
MH  - Mechanistic Target of Rapamycin Complex 1/metabolism
MH  - Mechanistic Target of Rapamycin Complex 2/metabolism
MH  - Signal Transduction/physiology
MH  - Stress, Physiological/*physiology
MH  - TOR Serine-Threonine Kinases/*metabolism/*physiology
PMC - PMC8147357
OTO - NOTNLM
OT  - Akt
OT  - TOR
OT  - anoxia
OT  - cell signaling
OT  - dauer
OT  - environmental stress
OT  - estivation
OT  - hibernation
OT  - hypoxia
OT  - metabolism
OT  - protein translation
COIS- The authors declare no conflict of interest.
EDAT- 2021/06/03 06:00
MHDA- 2021/09/23 06:00
PMCR- 2021/05/01
CRDT- 2021/06/02 01:04
PHST- 2021/03/26 00:00 [received]
PHST- 2021/04/28 00:00 [revised]
PHST- 2021/04/30 00:00 [accepted]
PHST- 2021/06/02 01:04 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/09/23 06:00 [medline]
PHST- 2021/05/01 00:00 [pmc-release]
AID - biom11050681 [pii]
AID - biomolecules-11-00681 [pii]
AID - 10.3390/biom11050681 [doi]
PST - epublish
SO  - Biomolecules. 2021 May 1;11(5):681. doi: 10.3390/biom11050681.