PMID- 34065159
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20220716
IS  - 1467-3045 (Electronic)
IS  - 1467-3037 (Print)
IS  - 1467-3037 (Linking)
VI  - 43
IP  - 1
DP  - 2021 May 9
TI  - Critical Amino Acid Variants in HLA-DRB1 and -DQB1 Allotypes in the Development 
      of Classical Type 1 Diabetes and Latent Autoimmune Diabetes in Adults in the 
      Japanese Population.
PG  - 107-115
LID - 10.3390/cimb43010009 [doi]
AB  - The effects of amino acid variants encoded by the human leukocyte antigen (HLA) 
      class II on the development of classical type 1 diabetes (T1D) and latent 
      autoimmune diabetes in adults (LADA) have not been fully elucidated. We 
      retrospectively investigated the HLA-DRB1 and -DQB1 genes of 72 patients with 
      classical T1D and 102 patients with LADA in the Japanese population and compared 
      the frequencies of HLA-DRB1 and -DQB1 alleles between these patients and the 
      Japanese populations previously reported by another institution. We also 
      performed a blind association analysis with all amino acid positions in classical 
      T1D and LADA, and compared the associations of HLA-DRB1 and -DQB1 amino acid 
      positions in classical T1D and LADA. The frequency of DRss-Phe-13 was 
      significantly higher and those of DRss-Arg-13 and DQss-Gly-70 were significantly 
      lower in patients with classical T1D and LADA than in controls. The frequencies 
      of DRss-His-13 and DQss-Glu-70 were significantly higher in classical T1D patients 
      than in controls. The frequency of DRss-Ser-13 was significantly lower and that of 
      DQss-Arg-70 was significantly higher in LADA patients than in controls. HLA-DRss1 
      position 13 and HLA-DQss1 position 70 could be critical amino acid positions in 
      the development of classical T1D and LADA.
FAU - Katahira, Masahito
AU  - Katahira M
AUID- ORCID: 0000-0001-5250-8138
AD  - Nursing and Health, Aichi Prefectural University School of Nursing and Health, 
      Togoku, Kamishidami, Moriyama-ku, Nagoya 463-8502, Japan.
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 2-2-22, 
      Bunkyo, Ichinomiya 491-8558, Japan.
FAU - Tsunekawa, Taku
AU  - Tsunekawa T
AUID- ORCID: 0000-0003-1609-4550
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 2-2-22, 
      Bunkyo, Ichinomiya 491-8558, Japan.
FAU - Mizoguchi, Akira
AU  - Mizoguchi A
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 2-2-22, 
      Bunkyo, Ichinomiya 491-8558, Japan.
FAU - Yamaguchi, Mariko
AU  - Yamaguchi M
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 2-2-22, 
      Bunkyo, Ichinomiya 491-8558, Japan.
FAU - Tsuru, Kahori
AU  - Tsuru K
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 2-2-22, 
      Bunkyo, Ichinomiya 491-8558, Japan.
FAU - Takashima, Hiromi
AU  - Takashima H
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 2-2-22, 
      Bunkyo, Ichinomiya 491-8558, Japan.
FAU - Terada, Ryoma
AU  - Terada R
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 2-2-22, 
      Bunkyo, Ichinomiya 491-8558, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210509
PL  - Switzerland
TA  - Curr Issues Mol Biol
JT  - Current issues in molecular biology
JID - 100931761
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Amino Acid Substitution
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*epidemiology/*genetics/immunology
MH  - Female
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Japan/epidemiology
MH  - Latent Autoimmune Diabetes in Adults/*epidemiology/*genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Young Adult
PMC - PMC8928954
OTO - NOTNLM
OT  - HLA class II
OT  - amino acid variants
OT  - latent autoimmune diabetes in adults
OT  - type 1 diabetes
COIS- The authors declare no conflict of interest.
EDAT- 2021/06/03 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/05/09
CRDT- 2021/06/02 01:12
PHST- 2021/04/13 00:00 [received]
PHST- 2021/05/04 00:00 [revised]
PHST- 2021/05/07 00:00 [accepted]
PHST- 2021/06/02 01:12 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/05/09 00:00 [pmc-release]
AID - cimb43010009 [pii]
AID - cimb-43-00009 [pii]
AID - 10.3390/cimb43010009 [doi]
PST - epublish
SO  - Curr Issues Mol Biol. 2021 May 9;43(1):107-115. doi: 10.3390/cimb43010009.