PMID- 34065553 OWN - NLM STAT- MEDLINE DCOM- 20210625 LR - 20240402 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 18 IP - 10 DP - 2021 May 20 TI - The Health Impacts of Hazardous Chemical Exposures among Child Labourers in Low- and Middle-Income Countries. LID - 10.3390/ijerph18105496 [doi] LID - 5496 AB - Of 218 million working children worldwide, many are suspected to be exposed to hazardous chemicals. This review aims to synthesize reported evidence over the last two decades on chemical exposure and adverse health consequences in children labourers in low- and middle-income Countries (LMIC). Included studies investigated health outcomes related to chemical exposures among child labourers aged 5-18 in LMIC. Twenty-three papers were selected for review, focusing on pesticides (n = 5), solvents (n = 3), metals (n = 13) and persistent organic pollutants (POPs) (n = 2). Adverse health effects identified among child labourers included abnormal biomarkers, for example elevated blood and urine chemical concentrations, neurobehavioural deficits and neurological symptoms, mental health issues, oxidative stress and DNA damage, poor growth, asthma, and hypothyroidism. Workplace exposure to chemicals has pernicious health effects on child labourers. Large research gaps exist, in particular for long-term health impacts through chronic conditions and diseases with long latencies. A sizeable disease burden in later life is likely to be directly attributable to chemicals exposures. We urge national and international agencies concerned with child labour and occupational health, to prioritize research and interventions aiming to reduce noxious chemical exposures in workplaces where children are likely to be present. FAU - Scott, Natasha B AU - Scott NB AUID- ORCID: 0000-0002-6500-6281 AD - LSHTM Alumni, London SW1V 4LS, UK. FAU - Pocock, Nicola S AU - Pocock NS AD - Lumos Foundation, London EC3R 8NB, UK. AD - Gender Violence & Health Centre, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK. LA - eng PT - Journal Article PT - Review DEP - 20210520 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 RN - 0 (Hazardous Substances) SB - IM MH - Child MH - Cost of Illness MH - *Developing Countries MH - Hazardous Substances MH - Humans MH - *Occupational Health MH - Workplace PMC - PMC8160821 OTO - NOTNLM OT - chemical exposure OT - child labour OT - hazardous work OT - health impact COIS- The authors declare no conflict of interest. EDAT- 2021/06/03 06:00 MHDA- 2021/06/29 06:00 PMCR- 2021/05/20 CRDT- 2021/06/02 01:13 PHST- 2021/01/28 00:00 [received] PHST- 2021/04/30 00:00 [revised] PHST- 2021/05/05 00:00 [accepted] PHST- 2021/06/02 01:13 [entrez] PHST- 2021/06/03 06:00 [pubmed] PHST- 2021/06/29 06:00 [medline] PHST- 2021/05/20 00:00 [pmc-release] AID - ijerph18105496 [pii] AID - ijerph-18-05496 [pii] AID - 10.3390/ijerph18105496 [doi] PST - epublish SO - Int J Environ Res Public Health. 2021 May 20;18(10):5496. doi: 10.3390/ijerph18105496.