PMID- 34067821
OWN - NLM
STAT- MEDLINE
DCOM- 20210723
LR  - 20240402
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 5
DP  - 2021 May 17
TI  - Dietary Polyphenol Intake Is Associated with Biological Aging, a Novel Predictor 
      of Cardiovascular Disease: Cross-Sectional Findings from the Moli-Sani Study.
LID - 10.3390/nu13051701 [doi]
LID - 1701
AB  - Biological aging, or the discrepancy between biological and chronological age of 
      a subject (Deltaage), has been associated with a polyphenol-rich Mediterranean diet 
      and represents a new, robust indicator of cardiovascular disease risk. We aimed 
      to disentangle the relationship of dietary polyphenols and total antioxidant 
      capacity with Deltaage in a cohort of Italians. A cross-sectional analysis was 
      performed on a sub-cohort of 4592 subjects (aged >/= 35 y; 51.8% women) from the 
      Moli-sani Study (2005-2010). Food intake was recorded by a 188-item 
      food-frequency questionnaire. The polyphenol antioxidant content (PAC)-score was 
      constructed to assess the total dietary content of polyphenols. Total antioxidant 
      capacity was measured in foods by these assays: trolox equivalent antioxidant 
      capacity (TEAC), total radical-trapping antioxidant parameter (TRAP) and ferric 
      reducing-antioxidant power (FRAP). A deep neural network, based on 36 circulating 
      biomarkers, was used to compute biological age and the resulting Deltaage, which was 
      tested as outcome in multivariable-adjusted linear regressions. Deltaage was 
      inversely associated with the PAC-score (beta = -0.31; 95%CI -0.39, -0.24) but not 
      with total antioxidant capacity of the diet. A diet rich in polyphenols, by 
      positively contributing to deceleration of the biological aging process, may 
      exert beneficial effects on the long-term risk of cardiovascular disease and 
      possibly of bone health.
FAU - Esposito, Simona
AU  - Esposito S
AD  - Department of Epidemiology and Prevention, IRCCS Neuromed, via dell'Elettronica, 
      86077 Pozzilli, Italy.
FAU - Gialluisi, Alessandro
AU  - Gialluisi A
AUID- ORCID: 0000-0002-7388-4463
AD  - Department of Epidemiology and Prevention, IRCCS Neuromed, via dell'Elettronica, 
      86077 Pozzilli, Italy.
FAU - Costanzo, Simona
AU  - Costanzo S
AD  - Department of Epidemiology and Prevention, IRCCS Neuromed, via dell'Elettronica, 
      86077 Pozzilli, Italy.
FAU - Di Castelnuovo, Augusto
AU  - Di Castelnuovo A
AD  - Mediterranea Cardiocentro, 80122 Napoli, Italy.
FAU - Ruggiero, Emilia
AU  - Ruggiero E
AUID- ORCID: 0000-0002-7109-1128
AD  - Department of Epidemiology and Prevention, IRCCS Neuromed, via dell'Elettronica, 
      86077 Pozzilli, Italy.
FAU - De Curtis, Amalia
AU  - De Curtis A
AUID- ORCID: 0000-0001-5104-0318
AD  - Department of Epidemiology and Prevention, IRCCS Neuromed, via dell'Elettronica, 
      86077 Pozzilli, Italy.
FAU - Persichillo, Mariarosaria
AU  - Persichillo M
AD  - Department of Epidemiology and Prevention, IRCCS Neuromed, via dell'Elettronica, 
      86077 Pozzilli, Italy.
FAU - Cerletti, Chiara
AU  - Cerletti C
AUID- ORCID: 0000-0002-4759-3179
AD  - Department of Epidemiology and Prevention, IRCCS Neuromed, via dell'Elettronica, 
      86077 Pozzilli, Italy.
FAU - Donati, Maria Benedetta
AU  - Donati MB
AD  - Department of Epidemiology and Prevention, IRCCS Neuromed, via dell'Elettronica, 
      86077 Pozzilli, Italy.
FAU - de Gaetano, Giovanni
AU  - de Gaetano G
AUID- ORCID: 0000-0002-7823-1402
AD  - Department of Epidemiology and Prevention, IRCCS Neuromed, via dell'Elettronica, 
      86077 Pozzilli, Italy.
FAU - Iacoviello, Licia
AU  - Iacoviello L
AUID- ORCID: 0000-0003-0514-5885
AD  - Department of Epidemiology and Prevention, IRCCS Neuromed, via dell'Elettronica, 
      86077 Pozzilli, Italy.
AD  - Department of Medicine and Surgery, Research Center in Epidemiology and 
      Preventive Medicine (EPIMED), University of Insubria, 21100 Varese-Como, Italy.
FAU - Bonaccio, Marialaura
AU  - Bonaccio M
AD  - Department of Epidemiology and Prevention, IRCCS Neuromed, via dell'Elettronica, 
      86077 Pozzilli, Italy.
FAU - On Behalf Of The Investigators For The Moli-Sani Study
AU  - On Behalf Of The Investigators For The Moli-Sani Study
LA  - eng
GR  - F/080032/01-03/X35/Ministero dello Sviluppo Economico/
GR  - RF-2018-12367074/Ministero della Salute/
PT  - Journal Article
DEP - 20210517
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Polyphenols)
SB  - IM
MH  - Adult
MH  - Aging/blood/*physiology
MH  - Antioxidants/*analysis
MH  - Biomarkers/blood
MH  - Cardiovascular Diseases/*etiology
MH  - Chronobiology Phenomena
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Diet/adverse effects
MH  - Diet Surveys
MH  - Diet, Mediterranean/statistics & numerical data
MH  - Eating/*physiology
MH  - Female
MH  - Heart Disease Risk Factors
MH  - Humans
MH  - Italy
MH  - Linear Models
MH  - Male
MH  - Neural Networks, Computer
MH  - Polyphenols/*analysis
MH  - Risk Assessment
PMC - PMC8157169
OTO - NOTNLM
OT  - biological aging
OT  - bone health
OT  - cardiovascular disease
OT  - dietary polyphenols
COIS- None of the authors of the present manuscript have conflicts of interest to 
      disclose.
EDAT- 2021/06/03 06:00
MHDA- 2021/07/24 06:00
PMCR- 2021/05/17
CRDT- 2021/06/02 01:20
PHST- 2021/04/13 00:00 [received]
PHST- 2021/05/12 00:00 [revised]
PHST- 2021/05/12 00:00 [accepted]
PHST- 2021/06/02 01:20 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/07/24 06:00 [medline]
PHST- 2021/05/17 00:00 [pmc-release]
AID - nu13051701 [pii]
AID - nutrients-13-01701 [pii]
AID - 10.3390/nu13051701 [doi]
PST - epublish
SO  - Nutrients. 2021 May 17;13(5):1701. doi: 10.3390/nu13051701.