PMID- 34069058
OWN - NLM
STAT- MEDLINE
DCOM- 20210803
LR  - 20210803
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 5
DP  - 2021 May 14
TI  - The Association between Nutritional Status and In-Hospital Mortality among 
      Patients with Heart Failure-A Result of the Retrospective Nutritional Status 
      Heart Study 2 (NSHS2).
LID - 10.3390/nu13051669 [doi]
LID - 1669
AB  - BACKGROUND: A nutritional status is related to the prognosis and length of 
      hospitalisation of patients with heart failure (HF). This study aims to assess 
      the effect of nutritional status on in-hospital mortality in patients with heart 
      failure. METHODS: We conducted a retrospective study and analysis of medical 
      records of 1056 patients admitted to the cardiology department of the University 
      Clinical Hospital in Wroclaw (Poland). RESULTS: A total of 1056 individuals were 
      included in the analysis. A total of 5.5% of patients died during an in-hospital 
      stay. It was found that in the sample group, 25% of patients who died had a BMI 
      (body mass index) within the normal range, 6% were underweight, 47% were 
      overweight, and 22% were obese. Our results show that non-survivors have a 
      significantly higher nutrition risk screening (NRS) >/=3 (21% vs. 3%; p < 0.001); 
      NYHA (New York Heart Association) grade 4 (70% vs. 24%; p < 0.001). The risk of 
      death was lower in obese patients (HR = 0.51; p = 0.028) and those with LDL 
      (low-density lipoprotein) levels from 116 to <190 mg/dL (HR = 0.10; p = 0.009, 
      compared to those with LDL <55 mg/dL). The risk of death was higher in those with 
      NRS (nutritional risk score) score >/=3 (HR = 2.31; p = 0.014), HFmrEF fraction (HR 
      = 4.69; p < 0.001), and LDL levels > 190 mg/dL (HR = 3.20; p = 0.038). 
      CONCLUSION: The malnutrition status correlates with an increased risk of death 
      during hospitalisation. Higher TC (total cholesterol) level were related to a 
      lower risk of death, which may indicate the "lipid paradox". Higher BMI results 
      were related to a lower risk of death, which may indicate the "obesity paradox".
FAU - Czapla, Michal
AU  - Czapla M
AUID- ORCID: 0000-0002-4245-5420
AD  - Faculty of Health Sciences, Wroclaw Medical University, 51-618 Wroclaw, Poland.
AD  - Centre for Heart Diseases, University Hospital, 50-566 Wroclaw, Poland.
FAU - Juarez-Vela, Raul
AU  - Juarez-Vela R
AD  - Faculty of Medicine, University of Salamanca, 37008 Salamanca, Spain.
FAU - Lokiec, Katarzyna
AU  - Lokiec K
AUID- ORCID: 0000-0002-0519-6917
AD  - Department of Propaedeutic of Civilization Diseases, Medical University of Lodz, 
      90-251 Lodz, Poland.
FAU - Karniej, Piotr
AU  - Karniej P
AUID- ORCID: 0000-0002-6489-2525
AD  - Faculty of Health Sciences, Wroclaw Medical University, 51-618 Wroclaw, Poland.
LA  - eng
GR  - SUB.E140.21.108/Ministry of Science and Higher Education of Poland/
PT  - Journal Article
DEP - 20210514
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Mass Index
MH  - Female
MH  - *Heart
MH  - Heart Failure/*mortality
MH  - *Hospital Mortality
MH  - Hospitalization
MH  - Humans
MH  - Length of Stay
MH  - Male
MH  - Malnutrition/mortality
MH  - Middle Aged
MH  - New York
MH  - *Nutritional Status
MH  - Obesity/mortality
MH  - Overweight/epidemiology
MH  - Poland/epidemiology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Thinness/epidemiology
PMC - PMC8156051
OTO - NOTNLM
OT  - NRS2002
OT  - heart failure
OT  - lipid paradox
OT  - malnutrition
OT  - nutritional status
OT  - obesity paradox
COIS- The authors declare no conflict of interest.
EDAT- 2021/06/03 06:00
MHDA- 2021/08/04 06:00
PMCR- 2021/05/14
CRDT- 2021/06/02 01:24
PHST- 2021/03/27 00:00 [received]
PHST- 2021/05/02 00:00 [revised]
PHST- 2021/05/12 00:00 [accepted]
PHST- 2021/06/02 01:24 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/08/04 06:00 [medline]
PHST- 2021/05/14 00:00 [pmc-release]
AID - nu13051669 [pii]
AID - nutrients-13-01669 [pii]
AID - 10.3390/nu13051669 [doi]
PST - epublish
SO  - Nutrients. 2021 May 14;13(5):1669. doi: 10.3390/nu13051669.