PMID- 34069233
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231111
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 13
IP  - 5
DP  - 2021 May 14
TI  - Recent Advances in pH- or/and Photo-Responsive Nanovehicles.
LID - 10.3390/pharmaceutics13050725 [doi]
LID - 725
AB  - The combination of nanotechnology and chemotherapy has resulted in more effective 
      drug design via the development of nanomaterial-based drug delivery systems 
      (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or 
      external signals can offer precisely controlled delivery of preloaded 
      therapeutics. Among the various DDSs, the photo-triggered system improves the 
      efficacy and safety of treatment through spatiotemporal manipulation of light. 
      Additionally, pH-induced delivery is one of the most widely studied strategies 
      for targeting the acidic micro-environment of solid tumors. Accordingly, in this 
      review, we discuss representative strategies for designing DDSs using light as an 
      exogenous signal or pH as an endogenous trigger.
FAU - Shin, Yuseon
AU  - Shin Y
AD  - Department of Global Innovative Drugs, The Graduate School of Chung-Ang 
      University and College of Pharmacy, Chung-Ang University, 221 Heukseok-dong, 
      Seoul 06974, Korea.
FAU - Husni, Patihul
AU  - Husni P
AUID- ORCID: 0000-0001-8448-0491
AD  - Department of Global Innovative Drugs, The Graduate School of Chung-Ang 
      University and College of Pharmacy, Chung-Ang University, 221 Heukseok-dong, 
      Seoul 06974, Korea.
FAU - Kang, Kioh
AU  - Kang K
AD  - Department of Global Innovative Drugs, The Graduate School of Chung-Ang 
      University and College of Pharmacy, Chung-Ang University, 221 Heukseok-dong, 
      Seoul 06974, Korea.
FAU - Lee, Dayoon
AU  - Lee D
AD  - Department of Global Innovative Drugs, The Graduate School of Chung-Ang 
      University and College of Pharmacy, Chung-Ang University, 221 Heukseok-dong, 
      Seoul 06974, Korea.
FAU - Lee, Sehwa
AU  - Lee S
AD  - Department of Global Innovative Drugs, The Graduate School of Chung-Ang 
      University and College of Pharmacy, Chung-Ang University, 221 Heukseok-dong, 
      Seoul 06974, Korea.
FAU - Lee, Eunseong
AU  - Lee E
AUID- ORCID: 0000-0002-4087-2407
AD  - Division of Biotechnology, The Catholic University of Korea, Bucheon 14662, 
      Korea.
FAU - Youn, Yuseok
AU  - Youn Y
AD  - School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
FAU - Oh, Kyungtaek
AU  - Oh K
AD  - Department of Global Innovative Drugs, The Graduate School of Chung-Ang 
      University and College of Pharmacy, Chung-Ang University, 221 Heukseok-dong, 
      Seoul 06974, Korea.
LA  - eng
GR  - 2015R1A5A1008958/Ministry of Science and ICT, South Korea/
GR  - 2021R1A2C2008519/Ministry of Science and ICT, South Korea/
PT  - Journal Article
PT  - Review
DEP - 20210514
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC8157172
OTO - NOTNLM
OT  - acid-labile bond
OT  - chemotherapy
OT  - light
OT  - nanovehicles
OT  - pH
OT  - photodynamic
OT  - photothermal
OT  - protonation
OT  - stimuli
COIS- The authors declare no conflict of interest.
EDAT- 2021/06/03 06:00
MHDA- 2021/06/03 06:01
PMCR- 2021/05/14
CRDT- 2021/06/02 01:25
PHST- 2021/04/26 00:00 [received]
PHST- 2021/05/11 00:00 [revised]
PHST- 2021/05/11 00:00 [accepted]
PHST- 2021/06/02 01:25 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/06/03 06:01 [medline]
PHST- 2021/05/14 00:00 [pmc-release]
AID - pharmaceutics13050725 [pii]
AID - pharmaceutics-13-00725 [pii]
AID - 10.3390/pharmaceutics13050725 [doi]
PST - epublish
SO  - Pharmaceutics. 2021 May 14;13(5):725. doi: 10.3390/pharmaceutics13050725.