PMID- 34070665
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210615
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 11
DP  - 2021 May 25
TI  - IgA Vasculitis and IgA Nephropathy: Same Disease?
LID - 10.3390/jcm10112310 [doi]
LID - 2310
AB  - Many authors suggested that IgA Vasculitis (IgAV) and IgA Nephropathy (IgAN) 
      would be two clinical manifestations of the same disease; in particular, that 
      IgAV would be the systemic form of the IgAN. A limited number of studies have 
      included sufficient children or adults with IgAN or IgAV (with or without 
      nephropathy) and followed long enough to conclude on differences or similarities 
      in terms of clinical, biological or histological presentation, physiopathology, 
      genetics or prognosis. All therapeutic trials available on IgAN excluded patients 
      with vasculitis. IgAV and IgAN could represent different extremities of a 
      continuous spectrum of the same disease. Due to skin rash, patients with IgAV are 
      diagnosed precociously. Conversely, because of the absence of any clinical signs, 
      a renal biopsy is practiced for patients with an IgAN to confirm nephropathy at 
      any time of the evolution of the disease, which could explain the frequent 
      chronic lesions at diagnosis. Nevertheless, the question that remains unsolved is 
      why do patients with IgAN not have skin lesions and some patients with IgAV not 
      have nephropathy? Larger clinical studies are needed, including both diseases, 
      with a common histological classification, and stratified on age and genetic 
      background to assess renal prognosis and therapeutic strategies.
FAU - Pillebout, Evangeline
AU  - Pillebout E
AUID- ORCID: 0000-0002-1826-8457
AD  - Nephrology Unit, Saint-Louis Hospital, 75010 Paris, France.
AD  - INSERM 1149, Center of Research on Inflammation, 75870 Paris, France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210525
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8197792
OTO - NOTNLM
OT  - IgA Nephropathy
OT  - IgA Vasculitis
OT  - adults
OT  - children
OT  - genetics
OT  - physiopathology
OT  - presentation
OT  - prognosis
OT  - treatment
COIS- No conflicts of interest to declare.
EDAT- 2021/06/03 06:00
MHDA- 2021/06/03 06:01
PMCR- 2021/05/25
CRDT- 2021/06/02 01:29
PHST- 2021/04/08 00:00 [received]
PHST- 2021/05/17 00:00 [revised]
PHST- 2021/05/19 00:00 [accepted]
PHST- 2021/06/02 01:29 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/06/03 06:01 [medline]
PHST- 2021/05/25 00:00 [pmc-release]
AID - jcm10112310 [pii]
AID - jcm-10-02310 [pii]
AID - 10.3390/jcm10112310 [doi]
PST - epublish
SO  - J Clin Med. 2021 May 25;10(11):2310. doi: 10.3390/jcm10112310.