PMID- 34070696
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 11
DP  - 2021 May 25
TI  - Dysfunction of the Neurovascular Unit in Ischemic Stroke: Highlights on microRNAs 
      and Exosomes as Potential Biomarkers and Therapy.
LID - 10.3390/ijms22115621 [doi]
LID - 5621
AB  - Ischemic stroke is a damaging cerebral vascular disease associated with high 
      disability and mortality rates worldwide. In spite of the continuous development 
      of new diagnostic and prognostic methods, early detection and outcome prediction 
      are often very difficult. The neurovascular unit (NVU) is a complex multicellular 
      entity linking the interactions between neurons, glial cells, and brain vessels. 
      Novel research has revealed that exosome-mediated transfer of microRNAs plays an 
      important role in cell-to-cell communication and, thus, is integral in the 
      multicellular crosstalk within the NVU. After a stroke, NVU homeostasis is 
      altered, which induces the release of several potential biomarkers into the blood 
      vessels. The addition of biological data representing all constituents of the NVU 
      to clinical and neuroradiological findings can significantly advance stroke 
      evaluation and prognosis. In this review, we present the current literature 
      regarding the possible beneficial roles of exosomes derived from the components 
      of the NVU and multipotent mesenchymal stem cells in preclinical studies of 
      ischemic stroke. We also discuss the most relevant clinical trials on the 
      diagnostic and prognostic roles of exosomes in stroke patients.
FAU - Forro, Timea
AU  - Forro T
AUID- ORCID: 0000-0002-5137-1819
AD  - 2nd Clinic of Neurology, Targu Mures County Emergency Clinical Hospital, 540136 
      Targu Mures, Romania.
AD  - Doctoral School, 'George Emil Palade' University of Medicine, Pharmacy, Science, 
      and Technology of Targu Mures, 540142 Targu Mures, Romania.
FAU - Bajko, Zoltan
AU  - Bajko Z
AD  - 1st Clinic of Neurology, Targu Mures County Emergency Clinical Hospital, 540136 
      Targu Mures, Romania.
AD  - Department of Neurology, 'George Emil Palade' University of Medicine, Pharmacy, 
      Science, and Technology of Targu Mures, 540142 Targu Mures, Romania.
FAU - Balasa, Adrian
AU  - Balasa A
AD  - Clinic of Neurosurgery, Targu Mures County Emergency Clinical Hospital, 540136 
      Targu Mures, Romania.
AD  - Department of Neurosurgery, 'George Emil Palade' University of Medicine, 
      Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania.
FAU - Balasa, Rodica
AU  - Balasa R
AD  - 1st Clinic of Neurology, Targu Mures County Emergency Clinical Hospital, 540136 
      Targu Mures, Romania.
AD  - Department of Neurology, 'George Emil Palade' University of Medicine, Pharmacy, 
      Science, and Technology of Targu Mures, 540142 Targu Mures, Romania.
LA  - eng
GR  - 10126/2/17.12.2020/Universitatea de Medicina, Farmacie, Stiinte si Tehnologie 
      "George Emil Palade" din Targu Mures/
PT  - Journal Article
PT  - Review
DEP - 20210525
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biomarkers)
RN  - 0 (Circulating MicroRNA)
SB  - IM
MH  - Animals
MH  - Biomarkers/blood
MH  - Circulating MicroRNA/*blood
MH  - *Exosomes/metabolism/pathology
MH  - Humans
MH  - *Ischemic Stroke/blood/pathology/therapy
MH  - *Mesenchymal Stem Cell Transplantation
MH  - *Mesenchymal Stem Cells/metabolism/pathology
PMC - PMC8198979
OTO - NOTNLM
OT  - biomarkers
OT  - brain ischemia
OT  - exosomes
OT  - extracellular vesicles
OT  - mesenchymal stem cells
OT  - microRNAs
OT  - neurovascular unit
OT  - stroke
COIS- The authors declare no conflict of interest.
EDAT- 2021/06/03 06:00
MHDA- 2021/06/22 06:00
PMCR- 2021/05/25
CRDT- 2021/06/02 01:29
PHST- 2021/04/28 00:00 [received]
PHST- 2021/05/21 00:00 [revised]
PHST- 2021/05/23 00:00 [accepted]
PHST- 2021/06/02 01:29 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2021/05/25 00:00 [pmc-release]
AID - ijms22115621 [pii]
AID - ijms-22-05621 [pii]
AID - 10.3390/ijms22115621 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 May 25;22(11):5621. doi: 10.3390/ijms22115621.