PMID- 34070698
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210615
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 11
DP  - 2021 May 25
TI  - Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and 
      Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into 
      a Phase II Clinical Study.
LID - 10.3390/jcm10112313 [doi]
LID - 2313
AB  - (1) Background: We investigated the role of [11C]-methionine PET in a cohort of 
      newly diagnosed glioblastoma multiforme (GBM) patients to evaluate whether it 
      could modify the extent of surgical resection and improve radiation therapy 
      volume delineation. (2) Methods: Newly diagnosed GBM patients, ages 18-70, with a 
      Karnofsky performance scale (KPS) >/= 70 with available MRI and [11C]-methionine 
      PET were included. Patients were treated with different amounts of surgical 
      resection followed by radio-chemotherapy. The role of [11C]-methionine PET in 
      surgical and RT planning was analyzed. A threshold of SUVmax was searched. (3) 
      Results: From August 2013 to April 2016, 93 patients were treated and included in 
      this analysis. Residual tumor volume was detected in 63 cases on MRI and in 78 on 
      [11C]-methionine PET, including 15 receiving gross total resection. The location 
      of uptake was mainly observed in FLAIR abnormalities. [11C]-methionine uptake 
      changed RT volume in 11% of patients. The presence of [11C]-methionine uptake in 
      patients receiving GTR proved to influence survival (p = 0.029). The threshold of 
      the SUVmax conditioning outcome was five. (4) Conclusions: [11C]-methionine PET 
      allowed to detect areas at higher risk of recurrence located in FLAIR 
      abnormalities in patients affected by GBM. A challenging issue is represented by 
      integrating morphological and functional imaging to better define the extent of 
      surgical resection to perform.
FAU - Pessina, Federico
AU  - Pessina F
AD  - Neurosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, 
      Italy.
AD  - Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 
      Milan, Italy.
FAU - Navarria, Pierina
AU  - Navarria P
AUID- ORCID: 0000-0002-6913-1442
AD  - Radiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, 
      Rozzano, 20089 Milan, Italy.
FAU - Clerici, Elena
AU  - Clerici E
AD  - Radiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, 
      Rozzano, 20089 Milan, Italy.
FAU - Bellu, Luisa
AU  - Bellu L
AUID- ORCID: 0000-0002-7286-4014
AD  - Radiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, 
      Rozzano, 20089 Milan, Italy.
FAU - Franzini, Andrea
AU  - Franzini A
AD  - Neurosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, 
      Italy.
FAU - Milani, Davide
AU  - Milani D
AD  - Neurosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, 
      Italy.
FAU - Simonelli, Matteo
AU  - Simonelli M
AUID- ORCID: 0000-0002-5264-1251
AD  - Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 
      Milan, Italy.
AD  - Oncology and Hematology Department, IRCCS Humanitas Research Hospital, Rozzano, 
      20089 Milan, Italy.
FAU - Persico, Pasquale
AU  - Persico P
AUID- ORCID: 0000-0003-2446-8604
AD  - Oncology and Hematology Department, IRCCS Humanitas Research Hospital, Rozzano, 
      20089 Milan, Italy.
FAU - Politi, Letterio S
AU  - Politi LS
AUID- ORCID: 0000-0002-6190-6688
AD  - Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 
      Milan, Italy.
AD  - Neuroradiology Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 
      Milan, Italy.
FAU - Casarotti, Alessandra
AU  - Casarotti A
AD  - Neurosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, 
      Italy.
FAU - Fernandes, Bethania
AU  - Fernandes B
AUID- ORCID: 0000-0002-4327-1586
AD  - Pathology Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, 
      Italy.
FAU - Olei, Simone
AU  - Olei S
AD  - Neurosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, 
      Italy.
FAU - Sollini, Martina
AU  - Sollini M
AD  - Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 
      Milan, Italy.
AD  - Diagnostic Imaging Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 
      Milan, Italy.
FAU - Chiti, Arturo
AU  - Chiti A
AD  - Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 
      Milan, Italy.
AD  - Pathology Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, 
      Italy.
FAU - Scorsetti, Marta
AU  - Scorsetti M
AD  - Neurosurgery Department, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, 
      Italy.
AD  - Radiotherapy and Radiosurgery Department, IRCCS Humanitas Research Hospital, 
      Rozzano, 20089 Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20210525
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8198980
OTO - NOTNLM
OT  - [11C]-methionine PET
OT  - newly diagnosed glioblastoma
OT  - radiation therapy
OT  - supratotal resection
OT  - surgery
COIS- The authors declare no conflict of interest.
EDAT- 2021/06/03 06:00
MHDA- 2021/06/03 06:01
PMCR- 2021/05/25
CRDT- 2021/06/02 01:29
PHST- 2021/03/30 00:00 [received]
PHST- 2021/05/20 00:00 [revised]
PHST- 2021/05/21 00:00 [accepted]
PHST- 2021/06/02 01:29 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/06/03 06:01 [medline]
PHST- 2021/05/25 00:00 [pmc-release]
AID - jcm10112313 [pii]
AID - jcm-10-02313 [pii]
AID - 10.3390/jcm10112313 [doi]
PST - epublish
SO  - J Clin Med. 2021 May 25;10(11):2313. doi: 10.3390/jcm10112313.