PMID- 34070835
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210615
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 11
DP  - 2021 May 30
TI  - Associations between High-Density Lipoprotein Functionality and Major Adverse 
      Cardiovascular Events in Patients Who Have Undergone Coronary Computed Tomography 
      Angiography.
LID - 10.3390/jcm10112431 [doi]
LID - 2431
AB  - The present study aimed to investigate the associations between high-density 
      lipoprotein (HDL) functionality and major adverse cardiovascular events (MACE) in 
      patients who have undergone coronary computed tomography angiography (CCTA). We 
      performed a prospective cohort study and enrolled 151 patients who underwent CCTA 
      and had a follow-up of up to 5 years. We measured cholesterol efflux capacity 
      (CEC), caspase-3/7 activity and monocyte chemoattractant protein-1 (MCP-1) 
      secretion as bioassays of HDL functionality. The patients were divided into 
      MACE(-) (n = 138) and MACE(+) (n = 13) groups. While there was no significant 
      difference in %CEC, caspase-3/7 activity or MCP-1 secretion between the MACE(-) 
      and MACE(+) groups, total CEC and HDL cholesterol (HDL-C) in the MACE(+) group 
      were significantly lower than those in the MACE(-) group. Total CEC was 
      correlated with HDL-C. A receiver-operating characteristic curve analysis showed 
      that there was no significant difference between the areas under the curves for 
      total CEC and HDL-C. In conclusion, total CEC in addition to HDL-C, but not %CEC, 
      was associated with the presence of MACE. On the other hand, HDL functionality 
      with regard to anti-inflammatory and anti-apoptosis effects was not associated 
      with MACE.
FAU - Inoue, Hiroko
AU  - Inoue H
AD  - Department of Cardiology, Fukuoka University Nishijin Hospital, Fukuoka 814-8522, 
      Japan.
FAU - Shiga, Yuhei
AU  - Shiga Y
AD  - Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 
      814-0180, Japan.
FAU - Norimatsu, Kenji
AU  - Norimatsu K
AD  - Department of Cardiology, Fukuoka University Nishijin Hospital, Fukuoka 814-8522, 
      Japan.
AD  - Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 
      814-0180, Japan.
FAU - Tashiro, Kohei
AU  - Tashiro K
AD  - Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 
      814-0180, Japan.
FAU - Futami, Makito
AU  - Futami M
AD  - Department of Cardiology, Fukuoka University Nishijin Hospital, Fukuoka 814-8522, 
      Japan.
AD  - Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 
      814-0180, Japan.
FAU - Suematsu, Yasunori
AU  - Suematsu Y
AD  - Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 
      814-0180, Japan.
FAU - Sugihara, Makoto
AU  - Sugihara M
AUID- ORCID: 0000-0002-0103-9260
AD  - Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 
      814-0180, Japan.
FAU - Nishikawa, Hiroaki
AU  - Nishikawa H
AD  - Department of Cardiology, Fukuoka University Nishijin Hospital, Fukuoka 814-8522, 
      Japan.
FAU - Katsuda, Yousuke
AU  - Katsuda Y
AD  - Department of Cardiology, Fukuoka University Nishijin Hospital, Fukuoka 814-8522, 
      Japan.
FAU - Miura, Shin-Ichiro
AU  - Miura SI
AD  - Department of Cardiology, Fukuoka University Nishijin Hospital, Fukuoka 814-8522, 
      Japan.
AD  - Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 
      814-0180, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210530
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8199292
OTO - NOTNLM
OT  - cholesterol efflux capacity
OT  - high-density lipoprotein
OT  - major adverse cardiovascular events
COIS- The authors declare that there is no conflict of interest.
EDAT- 2021/06/03 06:00
MHDA- 2021/06/03 06:01
PMCR- 2021/05/30
CRDT- 2021/06/02 01:30
PHST- 2021/04/25 00:00 [received]
PHST- 2021/05/22 00:00 [revised]
PHST- 2021/05/26 00:00 [accepted]
PHST- 2021/06/02 01:30 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/06/03 06:01 [medline]
PHST- 2021/05/30 00:00 [pmc-release]
AID - jcm10112431 [pii]
AID - jcm-10-02431 [pii]
AID - 10.3390/jcm10112431 [doi]
PST - epublish
SO  - J Clin Med. 2021 May 30;10(11):2431. doi: 10.3390/jcm10112431.