PMID- 34071385 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210627 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 11 IP - 6 DP - 2021 May 28 TI - Can the MMPI Predict Adult ADHD? An Approach Using Machine Learning Methods. LID - 10.3390/diagnostics11060976 [doi] LID - 976 AB - (1) Background: Adult attention-deficit/hyperactivity disorder (ADHD) symptoms cause various social difficulties due to attention deficit and impulsivity. In addition, in contrast to ADHD in childhood, ADHD in adulthood is difficult to diagnose due to mixed psychopathologies. This study aimed to determine whether it is possible to predict ADHD symptoms in adults using the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) with machine learning (ML) techniques; (2) Methods: Data collected from 5726 college students were analyzed. The MMPI-2-Restructured Form (MMPI-2-RF) was used, and ADHD symptoms in adults were evaluated using the Attention-Deficit/Hyperactivity Disorder Self-Report Scale (ASRS). For statistical analysis, three ML algorithms were used, i.e., K-nearest neighbors (KNN), linear discriminant analysis (LDA), and random forest, with the ASRS evaluation result as the dependent variable and the 50 MMPI-2-RF scales as predictors; (3) Results: When the KNN, LDA, and random forest techniques were applied, the accuracy was 93.1%, 91.2%, and 93.6%, respectively, and the area under the curve (AUC) was 0.722, 0.806, and 0.790, respectively. The AUC of the LDA method was the largest, with an excellent level of diagnostic accuracy; (4) Conclusions: ML using the MMPI-2 in a large group could provide reliable accuracy in screening for adult ADHD. FAU - Kim, Sunhae AU - Kim S AUID- ORCID: 0000-0001-7443-7684 AD - Department of Psychiatry, Hanyang University Medical Center, Seoul 04763, Korea. FAU - Lee, Hye-Kyung AU - Lee HK AD - Department of Nursing, College of Nursing and Health, Kongju National University, Gongju 32588, Korea. FAU - Lee, Kounseok AU - Lee K AUID- ORCID: 0000-0002-6084-5043 AD - Department of Psychiatry, Hanyang University Medical Center, Seoul 04763, Korea. LA - eng GR - NRF-2018R1D1A1B07050245/National Research Foundation of Korea/ GR - 20012931/Ministry of Trade, Industry and Energy (MOTIE, Korea)./ PT - Journal Article DEP - 20210528 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC8229212 OTO - NOTNLM OT - MMPI-2 OT - adult ADHD OT - detection OT - machine learning OT - screening COIS- The authors declare no conflict of interest. EDAT- 2021/06/03 06:00 MHDA- 2021/06/03 06:01 PMCR- 2021/05/28 CRDT- 2021/06/02 01:31 PHST- 2021/03/15 00:00 [received] PHST- 2021/04/25 00:00 [revised] PHST- 2021/05/27 00:00 [accepted] PHST- 2021/06/02 01:31 [entrez] PHST- 2021/06/03 06:00 [pubmed] PHST- 2021/06/03 06:01 [medline] PHST- 2021/05/28 00:00 [pmc-release] AID - diagnostics11060976 [pii] AID - diagnostics-11-00976 [pii] AID - 10.3390/diagnostics11060976 [doi] PST - epublish SO - Diagnostics (Basel). 2021 May 28;11(6):976. doi: 10.3390/diagnostics11060976.