PMID- 34071649
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210627
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 11
IP  - 6
DP  - 2021 May 28
TI  - Selecting the Most Relevant Brain Regions to Classify Children with Developmental 
      Dyslexia and Typical Readers by Using Complex Magnocellular Stimuli and Multiple 
      Kernel Learning.
LID - 10.3390/brainsci11060722 [doi]
LID - 722
AB  - Increasing evidence supports the presence of deficits in the visual magnocellular 
      (M) system in developmental dyslexia (DD). The M system is related to the 
      fronto-parietal attentional network. Previous neuroimaging studies have revealed 
      reduced/absent activation within the visual M pathway in DD, but they have failed 
      to characterize the extensive brain network activated by M stimuli. We performed 
      a multivariate pattern analysis on a Region of Interest (ROI) level to 
      differentiate between children with DD and age-matched typical readers (TRs) by 
      combining full-field sinusoidal gratings, controlled for spatial and temporal 
      frequencies and luminance contrast, and a coherent motion (CM) sensitivity task 
      at 6%-CML6, 15%-CML15 and 40%-CML40. ROIs spanning the entire visual dorsal 
      stream and ventral attention network (VAN) had higher discriminative weights and 
      showed higher act1ivation in TRs than in children with DD. Of the two tasks, CM 
      had the greatest weight when classifying TRs and children with DD in most of the 
      ROIs spanning these streams. For the CML6, activation within the right superior 
      parietal cortex positively correlated with reading skills. Our approach 
      highlighted the dorsal stream and the VAN as highly discriminative areas between 
      children with DD and TRs and allowed for a better characterization of the "dorsal 
      stream vulnerability" underlying DD.
FAU - Mascheretti, Sara
AU  - Mascheretti S
AD  - Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 
      Bosisio Parini, Italy.
FAU - Peruzzo, Denis
AU  - Peruzzo D
AUID- ORCID: 0000-0002-9480-379X
AD  - Neuroimaging Lab, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio 
      Parini, Italy.
FAU - Andreola, Chiara
AU  - Andreola C
AUID- ORCID: 0000-0002-9388-2772
AD  - Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 
      Bosisio Parini, Italy.
AD  - Laboratoire de Psychologie de Developpement et de l'Education de l'Enfant 
      (LaPsyDE), Universite de Paris, 75005 Paris, France.
FAU - Villa, Martina
AU  - Villa M
AUID- ORCID: 0000-0002-1776-5582
AD  - Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 
      Bosisio Parini, Italy.
FAU - Ciceri, Tommaso
AU  - Ciceri T
AD  - Neuroimaging Lab, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio 
      Parini, Italy.
FAU - Trezzi, Vittoria
AU  - Trezzi V
AD  - Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 
      Bosisio Parini, Italy.
FAU - Marino, Cecilia
AU  - Marino C
AD  - The Division of Child and Youth Psychiatry at the Centre for Addiction and Mental 
      Health (CAMH), Toronto, ON M6J 1H4, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada.
FAU - Arrigoni, Filippo
AU  - Arrigoni F
AUID- ORCID: 0000-0002-5508-1149
AD  - Neuroimaging Lab, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio 
      Parini, Italy.
LA  - eng
GR  - Ricerca Corrente 2019/Italian Ministry of Health Grants/
GR  - Ricerca Corrente 2020/Italian Ministry of Health Grants/
GR  - Cinque per mille/
PT  - Journal Article
DEP - 20210528
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC8228080
OTO - NOTNLM
OT  - attention
OT  - developmental dyslexia
OT  - dorsal stream vulnerability
OT  - fMRI
OT  - multiple kernel learning
OT  - visual dorsal pathway
COIS- The authors declare no conflict of interest. (IRB:CE150166).
EDAT- 2021/06/03 06:00
MHDA- 2021/06/03 06:01
PMCR- 2021/05/28
CRDT- 2021/06/02 01:32
PHST- 2021/04/07 00:00 [received]
PHST- 2021/05/20 00:00 [revised]
PHST- 2021/05/25 00:00 [accepted]
PHST- 2021/06/02 01:32 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/06/03 06:01 [medline]
PHST- 2021/05/28 00:00 [pmc-release]
AID - brainsci11060722 [pii]
AID - brainsci-11-00722 [pii]
AID - 10.3390/brainsci11060722 [doi]
PST - epublish
SO  - Brain Sci. 2021 May 28;11(6):722. doi: 10.3390/brainsci11060722.