PMID- 34071721
OWN - NLM
STAT- MEDLINE
DCOM- 20210615
LR  - 20210615
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 11
DP  - 2021 May 28
TI  - Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and 
      Secretion.
LID - 10.3390/ijms22115812 [doi]
LID - 5812
AB  - Changes in lifestyle in developed countries have triggered the prevalence of 
      obesity and type 2 diabetes mellitus (T2DM) in the latest years. Consequently, 
      these metabolic diseases associated to insulin resistance, and the morbidity 
      associated with them, accounts for enormous costs for the health systems. The 
      best way to face this problem is to identify potential therapeutic targets and/or 
      early biomarkers to help in the treatment and in the early detection. In the 
      insulin receptor signaling cascade, the activities of protein tyrosine kinases 
      and phosphatases are coordinated, thus, protein tyrosine kinases amplify the 
      insulin signaling response, whereas phosphatases are required for the regulation 
      of the rate and duration of that response. The focus of this review is to 
      summarize the impact of transmembrane receptor protein tyrosine phosphatase 
      (RPTPs) in the insulin signaling cascade and secretion, and their implication in 
      metabolic diseases such as obesity and T2DM.
FAU - Sevillano, Julio
AU  - Sevillano J
AUID- ORCID: 0000-0001-7726-6673
AD  - Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San 
      Pablo-CEU, CEU Universities, Urbanizacion Monteprincipe, Alcorcon, 28925 Madrid, 
      Spain.
FAU - Sanchez-Alonso, Maria Gracia
AU  - Sanchez-Alonso MG
AUID- ORCID: 0000-0001-7788-8923
AD  - Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San 
      Pablo-CEU, CEU Universities, Urbanizacion Monteprincipe, Alcorcon, 28925 Madrid, 
      Spain.
FAU - Pizarro-Delgado, Javier
AU  - Pizarro-Delgado J
AUID- ORCID: 0000-0002-3735-844X
AD  - Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San 
      Pablo-CEU, CEU Universities, Urbanizacion Monteprincipe, Alcorcon, 28925 Madrid, 
      Spain.
FAU - Ramos-Alvarez, Maria Del Pilar
AU  - Ramos-Alvarez MDP
AUID- ORCID: 0000-0002-7727-7783
AD  - Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San 
      Pablo-CEU, CEU Universities, Urbanizacion Monteprincipe, Alcorcon, 28925 Madrid, 
      Spain.
LA  - eng
GR  - RTI2018-095615-B-I00/Ministerio de Ciencia, Innovacion y Universidades of Spain/
GR  - B2017/BMD- 3684/Comunidad de Madrid/
PT  - Journal Article
PT  - Review
DEP - 20210528
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Insulin)
RN  - EC 2.7.10.1 (Receptor, Insulin)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
RN  - EC 3.1.3.48 (Receptor-Like Protein Tyrosine Phosphatases, Class 2)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Humans
MH  - Insulin/*metabolism
MH  - Insulin Resistance
MH  - Obesity
MH  - Prevalence
MH  - Protein Tyrosine Phosphatases/metabolism
MH  - Receptor, Insulin/metabolism
MH  - Receptor-Like Protein Tyrosine Phosphatases, Class 2/*metabolism
MH  - Signal Transduction/physiology
PMC - PMC8198922
OTO - NOTNLM
OT  - T2DM
OT  - insulin secretion
OT  - insulin signaling
OT  - receptor protein tyrosine phosphatases (RPTP)
COIS- The authors declare no conflict of interest.
EDAT- 2021/06/03 06:00
MHDA- 2021/06/16 06:00
PMCR- 2021/05/28
CRDT- 2021/06/02 01:33
PHST- 2021/05/01 00:00 [received]
PHST- 2021/05/21 00:00 [revised]
PHST- 2021/05/24 00:00 [accepted]
PHST- 2021/06/02 01:33 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/06/16 06:00 [medline]
PHST- 2021/05/28 00:00 [pmc-release]
AID - ijms22115812 [pii]
AID - ijms-22-05812 [pii]
AID - 10.3390/ijms22115812 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 May 28;22(11):5812. doi: 10.3390/ijms22115812.