PMID- 34072080
OWN - NLM
STAT- MEDLINE
DCOM- 20211101
LR  - 20231107
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 10
IP  - 6
DP  - 2021 May 27
TI  - Autophagy and Extracellular Vesicles, Connected to rabGTPase Family, Support 
      Aggressiveness in Cancer Stem Cells.
LID - 10.3390/cells10061330 [doi]
LID - 1330
AB  - Even though cancers have been widely studied and real advances in therapeutic 
      care have been made in the last few decades, relapses are still frequently 
      observed, often due to therapeutic resistance. Cancer Stem Cells (CSCs) are, in 
      part, responsible for this resistance. They are able to survive harsh conditions 
      such as hypoxia or nutrient deprivation. Autophagy and Extracellular Vesicles 
      (EVs) secretion are cellular processes that help CSC survival. Autophagy is a 
      recycling process and EVs secretion is essential for cell-to-cell communication. 
      Their roles in stemness maintenance have been well described. A common pathway 
      involved in these processes is vesicular trafficking, and subsequently, 
      regulation by Rab GTPases. In this review, we analyze the role played by Rab 
      GTPases in stemness status, either directly or through their regulation of 
      autophagy and EVs secretion.
FAU - Brunel, Aude
AU  - Brunel A
AD  - EA 3842-CAPTuR, GEIST Institute, Faculty of Medicine, University of Limoges, 2 
      rue du Dr Marcland, CEDEX, 87025 Limoges, France.
FAU - Begaud, Gaelle
AU  - Begaud G
AD  - EA 3842-CAPTuR, GEIST Institute, Faculty of Medicine, University of Limoges, 2 
      rue du Dr Marcland, CEDEX, 87025 Limoges, France.
FAU - Auger, Clement
AU  - Auger C
AUID- ORCID: 0000-0001-5260-535X
AD  - EA 3842-CAPTuR, GEIST Institute, Faculty of Medicine, University of Limoges, 2 
      rue du Dr Marcland, CEDEX, 87025 Limoges, France.
FAU - Durand, Stephanie
AU  - Durand S
AUID- ORCID: 0000-0003-2434-9429
AD  - EA 3842-CAPTuR, GEIST Institute, Faculty of Medicine, University of Limoges, 2 
      rue du Dr Marcland, CEDEX, 87025 Limoges, France.
FAU - Battu, Serge
AU  - Battu S
AD  - EA 3842-CAPTuR, GEIST Institute, Faculty of Medicine, University of Limoges, 2 
      rue du Dr Marcland, CEDEX, 87025 Limoges, France.
FAU - Bessette, Barbara
AU  - Bessette B
AUID- ORCID: 0000-0001-6673-3694
AD  - EA 3842-CAPTuR, GEIST Institute, Faculty of Medicine, University of Limoges, 2 
      rue du Dr Marcland, CEDEX, 87025 Limoges, France.
FAU - Verdier, Mireille
AU  - Verdier M
AUID- ORCID: 0000-0002-8162-4856
AD  - EA 3842-CAPTuR, GEIST Institute, Faculty of Medicine, University of Limoges, 2 
      rue du Dr Marcland, CEDEX, 87025 Limoges, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210527
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
SB  - IM
MH  - Autophagy/*physiology
MH  - Cell Communication/physiology
MH  - Extracellular Vesicles/metabolism
MH  - Gene Expression Regulation, Neoplastic/*genetics
MH  - Humans
MH  - Neoplasms/*metabolism
MH  - Neoplastic Stem Cells/*metabolism
PMC - PMC8227744
OTO - NOTNLM
OT  - autophagy
OT  - cancer stem cells
OT  - extracellular vesicles
OT  - rab family
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2021/06/03 06:00
MHDA- 2021/11/03 06:00
PMCR- 2021/05/27
CRDT- 2021/06/02 01:34
PHST- 2021/04/08 00:00 [received]
PHST- 2021/05/20 00:00 [revised]
PHST- 2021/05/24 00:00 [accepted]
PHST- 2021/06/02 01:34 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2021/05/27 00:00 [pmc-release]
AID - cells10061330 [pii]
AID - cells-10-01330 [pii]
AID - 10.3390/cells10061330 [doi]
PST - epublish
SO  - Cells. 2021 May 27;10(6):1330. doi: 10.3390/cells10061330.