PMID- 34074374
OWN - NLM
STAT- MEDLINE
DCOM- 20210603
LR  - 20210603
IS  - 1000-8020 (Print)
IS  - 1000-8020 (Linking)
VI  - 50
IP  - 3
DP  - 2021 May
TI  - [Determination of trace low molecular mass aldehydes in air by ultra-fast liquid 
      chromatography-tandem mass spectrometry].
PG  - 488-494
LID - 10.19813/j.cnki.weishengyanjiu.2021.03.024 [doi]
AB  - OBJECTIVE: To establish a rapid and accurate method for the determination of 
      trace acetaldehyde, acrolein, methacrylaldehyde, crotonaldehyde in the air by 
      ultra-fast liquid chromatography-tandem mass spectrometry(UFLC-MS/MS). METHODS: 
      The air sample was concentrated and derivatived by 3-methyl-2(3 
      H)-benzothiazolonhydrazone(MBTH), and the effect of derivative conditions 
      including the concentration of MBTH, the pH, the derivative time and temperature 
      was investigated. The stability of derivatives, the cracking mechanism of mass 
      spectrometry, the matrix effect of the method and air sampling efficiency were 
      studied. The chromatographic separation was carried out on a Shim-pack XR-ODS II 
      column(100 mmx2. 0 mm, 2. 2 mum) by using water/methanol solution as the mobile 
      phase with the gradient elution. Detection was performed in positive 
      multi-reaction monitoring(MRM) mode for quantification by using external standard 
      method. RESULTS: The four analytes showed good linear relationship within the 
      range of 1. 00-100 mug/L(calculated by aldehyde) with a correlation coefficient 
      r>/=0. 9990. The limits of quantitation(LOQs) of the method(concentrated with 10 L 
      air) were 0. 5 mug/m~3 in air, for acetaldehyde, acrolein, methacrylaldehyde, 
      crotonaldehyde. The recoveries of the method were 90. 6%-97. 8% at the three 
      spiked levels, and the relative standard deviations(RSDs) were between 1. 9%-6. 
      4%(n=6), the average sampling efficiency was between 91. 0%-97. 1%. CONCLUSION: 
      The developed method is simple, less interference and specificity, and is 
      suitable for the simultaneous rapid determination of trace acetaldehyde, 
      acrolein, methacrylaldehyde, crotonaldehyde in air of work place.
FAU - Chen, Xiaohong
AU  - Chen X
AD  - Key Laboratory of Health Risk Appraisal for Trace Toxic Chemicals of Zhejiang 
      Province, Ningbo Municipal Center for Disease Control and Prevention, Ningbo 
      315010, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - School of Environmental Science and Engineering, Zhejiang Gongshang University, 
      Hangzhou 310018, China.
FAU - Shi, Yuejin
AU  - Shi Y
AD  - School of Environmental Science and Engineering, Zhejiang Gongshang University, 
      Hangzhou 310018, China.
FAU - Cai, Meiqiang
AU  - Cai M
AD  - School of Environmental Science and Engineering, Zhejiang Gongshang University, 
      Hangzhou 310018, China.
FAU - Jin, Micong
AU  - Jin M
AD  - Key Laboratory of Health Risk Appraisal for Trace Toxic Chemicals of Zhejiang 
      Province, Ningbo Municipal Center for Disease Control and Prevention, Ningbo 
      315010, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Wei Sheng Yan Jiu
JT  - Wei sheng yan jiu = Journal of hygiene research
JID - 9426367
RN  - 0 (Aldehydes)
SB  - IM
MH  - *Aldehydes
MH  - Chromatography, High Pressure Liquid
MH  - Chromatography, Liquid
MH  - *Tandem Mass Spectrometry
OTO - NOTNLM
OT  - acetaldehyde
OT  - acrolein
OT  - air
OT  - crotonaldehyde
OT  - methacrylaldehyde
OT  - ultra-fast liquid chromatography-tandem mass spectrometry
OT  - work place
EDAT- 2021/06/03 06:00
MHDA- 2021/06/04 06:00
CRDT- 2021/06/02 05:41
PHST- 2021/06/02 05:41 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/06/04 06:00 [medline]
AID - 10.19813/j.cnki.weishengyanjiu.2021.03.024 [doi]
PST - ppublish
SO  - Wei Sheng Yan Jiu. 2021 May;50(3):488-494. doi: 
      10.19813/j.cnki.weishengyanjiu.2021.03.024.