PMID- 34075617
OWN - NLM
STAT- MEDLINE
DCOM- 20220221
LR  - 20220221
IS  - 1365-2710 (Electronic)
IS  - 0269-4727 (Linking)
VI  - 47
IP  - 1
DP  - 2022 Jan
TI  - Combination therapy for disseminated strongyloidiasis with associated 
      vancomycin-resistant, linezolid-intermediate Enterococcus faecium meningitis: A 
      case report.
PG  - 121-124
LID - 10.1111/jcpt.13448 [doi]
AB  - WHAT IS KNOWN AND OBJECTIVE: The rhabditid nematode Strongyloides stercoralis is 
      the major causative agent of disseminated strongyloidiasis (DS). In rare cases, 
      DS has caused enterococcal meningitis. If DS-associated vancomycin-resistant 
      Enterococcus faecium (VRE) meningitis is suspected, combination antibiotic 
      therapy should be considered. CASE SUMMARY: We present a case of a 61-year-old 
      male who developed DS associated with vancomycin-resistant and 
      linezolid-intermediate E. faecium meningitis after receiving corticosteroids. The 
      VRE meningitis was treated with high-dose daptomycin 12 mg/kg, linezolid, 
      tigecycline and quinupristin/dalfopristin. Despite negative cultures, the patient 
      expired. WHAT IS NEW AND CONCLUSION: In patients with DS-associated VRE 
      meningitis, early use of combination therapy may be warranted to improve patient 
      outcomes.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Tobin, Morgan A
AU  - Tobin MA
AD  - Department of Pharmacy Services, Saint Joseph Hospital, Lexington, KY, USA.
FAU - Dougherty, David F
AU  - Dougherty DF
AD  - Lexington Infectious Disease Consultants, Saint Joseph Hospital, Lexington, KY, 
      USA.
FAU - Ratliff, Patrick D
AU  - Ratliff PD
AD  - Department of Pharmacy Services, Saint Joseph Hospital, Lexington, KY, USA.
FAU - Judd, W Russ
AU  - Judd WR
AD  - Department of Pharmacy Services, Saint Joseph Hospital, Lexington, KY, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20210602
PL  - England
TA  - J Clin Pharm Ther
JT  - Journal of clinical pharmacy and therapeutics
JID - 8704308
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Adrenal Cortex Hormones/adverse effects
MH  - Anti-Bacterial Agents/administration & dosage/*therapeutic use
MH  - Dose-Response Relationship, Drug
MH  - *Drug Resistance, Multiple, Bacterial
MH  - Drug Therapy, Combination
MH  - Enterococcus faecium
MH  - Gram-Positive Bacterial Infections/*drug therapy
MH  - Humans
MH  - Male
MH  - Meningitis, Bacterial/*drug therapy
MH  - Microbial Sensitivity Tests
MH  - Middle Aged
MH  - Strongyloidiasis/chemically induced/*drug therapy
MH  - Vancomycin Resistance
OTO - NOTNLM
OT  - Strongyloides stercoralis
OT  - hyperinfection syndrome
OT  - meningitis
OT  - strongyloides
OT  - strongyloidiasis
OT  - vancomycin-resistant enterococcus
EDAT- 2021/06/03 06:00
MHDA- 2022/02/22 06:00
CRDT- 2021/06/02 06:56
PHST- 2021/03/26 00:00 [revised]
PHST- 2021/02/11 00:00 [received]
PHST- 2021/05/12 00:00 [accepted]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2022/02/22 06:00 [medline]
PHST- 2021/06/02 06:56 [entrez]
AID - 10.1111/jcpt.13448 [doi]
PST - ppublish
SO  - J Clin Pharm Ther. 2022 Jan;47(1):121-124. doi: 10.1111/jcpt.13448. Epub 2021 Jun 
      2.