PMID- 34076145
OWN - NLM
STAT- MEDLINE
DCOM- 20210603
LR  - 20220531
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 54
IP  - 9
DP  - 2021
TI  - Paternal obesity and its transgenerational effects on gastrointestinal function 
      in male rat offspring.
PG  - e11116
LID - S0100-879X2021000900602 [pii]
LID - 10.1590/1414-431X2020e11116 [doi]
LID - e11116
AB  - The interplay between obesity and gastrointestinal (GI) motility is 
      contradictory, and the transgenerational influence on this parameter is unknown. 
      We aimed to evaluate the GI function in a model of paternal obesity and two 
      subsequent generations of their male offspring. Newborn male rats were treated 
      with monosodium glutamate (MSG) and composed the F1 generation, while control 
      rats (CONT) received saline. At 90 days, male F1 were mated with non-obese 
      females to obtain male offspring (F2), which later mated with non-obese females 
      for obtaining male offspring of F3 generation. Lee Index analysis was adopted to 
      set up the obesity groups. Alternating current biosusceptometry (ACB) technique 
      was employed to calculate GI transit parameters: mean gastric emptying time 
      (MGET), mean cecum arrival time (MCAT), mean small intestinal transit time 
      (MSITT), and gastric frequency and amplitude of contractions. Glucose, insulin, 
      and leptin levels and duodenal morphometry were measured. F1 obese rats showed a 
      decrease in the frequency and amplitude of gastric contractions, while obese rats 
      from the F2 generation showed accelerated MGET and delayed MCAT and MSITT. 
      Glucose and leptin levels were increased in F1 and F2 generations. Insulin levels 
      decreased in F1, F2, and F3 generations. Duodenal morphometry was altered in all 
      three generations. Obesity may have paternal transgenerational transmission, and 
      it provoked disturbances in the gastrointestinal function of three generations.
FAU - Machado, M P R
AU  - Machado MPR
AUID- ORCID: 0000-0001-8412-2483
AD  - Instituto de Biociencias, Universidade Estadual Paulista Julio de Mesquita Filho, 
      Botucatu, SP, Brasil.
FAU - Gama, L A
AU  - Gama LA
AUID- ORCID: 0000-0002-8118-1047
AD  - Instituto de Ciencias Biologicas e da Saude, Universidade Federal de Mato Grosso, 
      Barra do Garcas, MT, Brasil.
FAU - Beckmann, A P S
AU  - Beckmann APS
AUID- ORCID: 0000-0002-6268-639X
AD  - Instituto de Ciencias Biologicas e da Saude, Universidade Federal de Mato Grosso, 
      Barra do Garcas, MT, Brasil.
FAU - Hauschildt, A T
AU  - Hauschildt AT
AUID- ORCID: 0000-0003-3058-0504
AD  - Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceara, 
      Fortaleza, CE, Brasil.
FAU - Dall'Agnol, D J R
AU  - Dall'Agnol DJR
AUID- ORCID: 0000-0002-2551-2382
AD  - Faculdade de Ciencias Agrarias, Biologicas, Engenharia e da Saude, Universidade 
      do Estado de Mato Grosso, Tangara da Serra, MT, Brasil.
FAU - Miranda, J R A
AU  - Miranda JRA
AUID- ORCID: 0000-0002-8306-8056
AD  - Instituto de Biociencias, Universidade Estadual Paulista Julio de Mesquita Filho, 
      Botucatu, SP, Brasil.
FAU - Cora, L A
AU  - Cora LA
AUID- ORCID: 0000-0001-8242-3653
AD  - Nucleo de Ciencias Biologicas, NUCIB, Universidade Estadual de Ciencias da Saude 
      de Alagoas (UNCISAL), Maceio, AL, Brasil.
FAU - Americo, M F
AU  - Americo MF
AUID- ORCID: 0000-0001-8474-3765
AD  - Instituto de Ciencias Biologicas e da Saude, Universidade Federal de Mato Grosso, 
      Barra do Garcas, MT, Brasil.
LA  - eng
PT  - Journal Article
DEP - 20210531
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Insulin)
RN  - 0 (Leptin)
SB  - IM
MH  - Animals
MH  - Female
MH  - Gastrointestinal Motility
MH  - Gastrointestinal Transit
MH  - Insulin
MH  - Leptin
MH  - Male
MH  - *Obesity/etiology
MH  - *Paternal Exposure
MH  - Pregnancy
MH  - Rats
PMC - PMC8186378
EDAT- 2021/06/03 06:00
MHDA- 2021/06/04 06:00
PMCR- 2021/05/31
CRDT- 2021/06/02 09:17
PHST- 2020/12/16 00:00 [received]
PHST- 2021/04/16 00:00 [accepted]
PHST- 2021/06/02 09:17 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/06/04 06:00 [medline]
PHST- 2021/05/31 00:00 [pmc-release]
AID - S0100-879X2021000900602 [pii]
AID - 10.1590/1414-431X2020e11116 [doi]
PST - epublish
SO  - Braz J Med Biol Res. 2021 May 31;54(9):e11116. doi: 10.1590/1414-431X2020e11116. 
      eCollection 2021.