PMID- 34076369
OWN - NLM
STAT- MEDLINE
DCOM- 20210805
LR  - 20231107
IS  - 2192-2659 (Electronic)
IS  - 2192-2640 (Print)
IS  - 2192-2640 (Linking)
VI  - 10
IP  - 13
DP  - 2021 Jul
TI  - Recent Developments in Nanomaterial-Based Shear-Sensitive Drug Delivery Systems.
PG  - e2002196
LID - 10.1002/adhm.202002196 [doi]
AB  - Nanomaterial-based drug delivery systems (DDSs) increase the efficacy of various 
      therapeutics, and shear stress has been shown to be a robust modulator of payload 
      release. In the past few decades, a deeper understanding has been gained of the 
      effects of flow in the body and its alteration in pathological microenvironments. 
      More recently, shear-responsive nanomaterial DDSs have been developed. Studies on 
      this subject mainly from the last decade are reviewed here, focusing on 
      innovations of the material design and mechanisms of the shear response. The two 
      most popular shear-controlled drug carriers distinguished by different release 
      mechanisms, that is, shear-deformable nanoparticles (NPs) and shear-dissociated 
      NP aggregates (NPAs), are surveyed. The influence of material structures on their 
      properties such as drug loading, circulation time, and shear sensitivity are 
      discussed. The drug development stages, therapeutic effects, limitations, and 
      potential of these DDSs are further inspected. The reviewed research emphasizes 
      the advantages and significance of nanomaterial-based shear-sensitive DDSs in the 
      field of targeted drug delivery. It is also believed that efforts to rationally 
      design nanomaterial DDSs responsive to shear may prompt a new class of 
      diagnostics and therapeutics for signaling and rectifying pathological flows in 
      the body.
CI  - (c) 2021 Wiley-VCH GmbH.
FAU - Wang, Yi
AU  - Wang Y
AUID- ORCID: 0000-0003-4106-5698
AD  - Department of Materials Science and Engineering, Lehigh University, Bethlehem, 
      PA, 18015, USA.
FAU - Pisapati, Avani V
AU  - Pisapati AV
AD  - Department of Bioengineering, Lehigh University, Bethlehem, PA, 18015, USA.
FAU - Zhang, X Frank
AU  - Zhang XF
AD  - Department of Bioengineering, Lehigh University, Bethlehem, PA, 18015, USA.
FAU - Cheng, Xuanhong
AU  - Cheng X
AUID- ORCID: 0000-0002-6331-8572
AD  - Department of Materials Science and Engineering, Lehigh University, Bethlehem, 
      PA, 18015, USA.
AD  - Department of Bioengineering, Lehigh University, Bethlehem, PA, 18015, USA.
LA  - eng
GR  - R21 HL152348/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20210602
PL  - Germany
TA  - Adv Healthc Mater
JT  - Advanced healthcare materials
JID - 101581613
RN  - 0 (Drug Carriers)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Drug Carriers
MH  - Drug Delivery Systems
MH  - Drug Development
MH  - *Nanoparticles
MH  - *Nanostructures
MH  - *Pharmaceutical Preparations
PMC - PMC8273148
MID - NIHMS1711545
OTO - NOTNLM
OT  - advanced nanomaterials
OT  - deformable nanoparticles
OT  - drug delivery systems
OT  - nanoparticle aggregates
OT  - shear-sensitive
COIS- Conflict of Interests: The authors declare no competing interests - financial or 
      otherwise.
EDAT- 2021/06/03 06:00
MHDA- 2021/08/06 06:00
PMCR- 2022/07/01
CRDT- 2021/06/02 09:27
PHST- 2021/04/21 00:00 [revised]
PHST- 2020/12/14 00:00 [received]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/08/06 06:00 [medline]
PHST- 2021/06/02 09:27 [entrez]
PHST- 2022/07/01 00:00 [pmc-release]
AID - 10.1002/adhm.202002196 [doi]
PST - ppublish
SO  - Adv Healthc Mater. 2021 Jul;10(13):e2002196. doi: 10.1002/adhm.202002196. Epub 
      2021 Jun 2.