PMID- 34077476
OWN - NLM
STAT- MEDLINE
DCOM- 20211103
LR  - 20220121
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 16
IP  - 6
DP  - 2021
TI  - HIV testing in patients who are HCV positive: Compliance with CDC guidelines in a 
      large healthcare system.
PG  - e0252412
LID - 10.1371/journal.pone.0252412 [doi]
LID - e0252412
AB  - BACKGROUND: There are approximately 300,000 people in the United States who are 
      co-infected with HIV and HCV. Several organizations recommend that individuals 
      who are HCV infected, as well as persons over the age of 13, should be HIV 
      tested. Comorbidities associated with HCV can be reduced with early 
      identification of HIV. Our objective was to determine whether providers routinely 
      followed HIV testing guidelines for patients who tested HCV positive (HCV+). 
      METHODS: A retrospective chart review was conducted of all patients in primary 
      care at an academic health system from 7/2015-3/2017 who tested HCV+. As part of 
      a primary database, HCV testing data was collected; HIV testing data was 
      abstracted manually. We collected and described the intervals between HCV and HIV 
      tests. To determine associations with HIV testing univariable and multivariable 
      analyses were performed. RESULTS: We identified 445 patients who tested HCV+: 
      56.6% were tested for HIV, the mean age was 57 +/- 10.9 years, 77% were from the 
      Birth Cohort born 1945-1965 (BC); 61% were male; and 51% were Black/AA. Patients 
      in the BC were more likely to be HIV tested if they were: male (p = 0.019), 
      Black/AA (p<0.001), and had Medicaid (p = 0.005). These differences were not 
      found in the non-BC. Six patients who were tested for both HIV and HCV were found 
      to be newly HIV positive at the time of testing. CONCLUSION: As demonstrated, 
      providers did not routinely follow CDC recommendations as almost half of the HCV+ 
      patients were not correctly tested for HIV. It is important to emphasize that six 
      persons were tested HIV positive simultaneously with their HCV+ diagnosis. If 
      providers did not follow the CDC guidelines, then these patients may not have 
      been identified. Improvements in EHR clinical decision support tools and provider 
      education can help improve the HIV testing rate among individuals who are HCV+.
FAU - Fleisher, Ilan
AU  - Fleisher I
AUID- ORCID: 0000-0001-7418-9908
AD  - MedStar Health Research Institute, MedStar Health, Hyattsville, MD, United States 
      of America.
AD  - New York Medical College, Valhalla, NY, United States of America.
FAU - Geboy, Alexander G
AU  - Geboy AG
AD  - MedStar Health Research Institute, MedStar Health, Hyattsville, MD, United States 
      of America.
AD  - Association of American Medical Colleges, Washington, DC, United States of 
      America.
FAU - Nichols, Whitney
AU  - Nichols W
AD  - MedStar Health Research Institute, MedStar Health, Hyattsville, MD, United States 
      of America.
AD  - Frank H. Netter School of Medicine at Quinnipiac, North Haven, CT, United States 
      of America.
FAU - Desale, Sameer
AU  - Desale S
AD  - MedStar Health Research Institute, MedStar Health, Hyattsville, MD, United States 
      of America.
FAU - Fernandez, Stephen
AU  - Fernandez S
AD  - MedStar Health Research Institute, MedStar Health, Hyattsville, MD, United States 
      of America.
FAU - Basch, Peter
AU  - Basch P
AD  - MedStar Health, Columbia, MD, United States of America.
FAU - Fishbein, Dawn A
AU  - Fishbein DA
AD  - MedStar Health Research Institute, MedStar Health, Hyattsville, MD, United States 
      of America.
AD  - MedStar Washington Hospital Center, Washington, DC, United States of America.
LA  - eng
GR  - UL1 TR001409/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210602
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Centers for Disease Control and Prevention, U.S.
MH  - Female
MH  - HIV/*isolation & purification
MH  - HIV Infections/*diagnosis/epidemiology/virology
MH  - HIV Testing/*standards
MH  - Hepacivirus/*physiology
MH  - Hepatitis C/*complications/virology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Practice Guidelines as Topic/*standards
MH  - Retrospective Studies
MH  - United States/epidemiology
PMC - PMC8171936
COIS- To the best of our knowledge, no conflict of interest, financial or other, 
      exists; except for Dr. Fishbein who has recently served as an Advisor for Gilead 
      regarding HCV Elimination. We have included acknowledgements after the 
      discussion. Dr. Fishbein has been funded by Gilead Sciences FOCUS Partnership for 
      her research and as an Advisor to Gilead on HCV Elimination. This does not alter 
      our adherence to PLOS ONE policies on sharing data and materials.
EDAT- 2021/06/03 06:00
MHDA- 2021/11/04 06:00
PMCR- 2021/06/02
CRDT- 2021/06/02 17:23
PHST- 2020/08/26 00:00 [received]
PHST- 2021/05/16 00:00 [accepted]
PHST- 2021/06/02 17:23 [entrez]
PHST- 2021/06/03 06:00 [pubmed]
PHST- 2021/11/04 06:00 [medline]
PHST- 2021/06/02 00:00 [pmc-release]
AID - PONE-D-20-26803 [pii]
AID - 10.1371/journal.pone.0252412 [doi]
PST - epublish
SO  - PLoS One. 2021 Jun 2;16(6):e0252412. doi: 10.1371/journal.pone.0252412. 
      eCollection 2021.