PMID- 34078718
OWN - NLM
STAT- MEDLINE
DCOM- 20210824
LR  - 20230726
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 97
IP  - 7
DP  - 2021 Aug 17
TI  - Prospective Evaluation of Health Care Provider and Patient Assessments in 
      Chemotherapy-Induced Peripheral Neurotoxicity.
PG  - e660-e672
LID - 10.1212/WNL.0000000000012300 [doi]
AB  - BACKGROUND AND OBJECTIVE: There is no agreement on the gold standard for 
      detection and grading of chemotherapy-induced peripheral neurotoxicity (CIPN) in 
      clinical trials. The objective is to perform an observational prospective study 
      to assess and compare patient-based and physician-based methods for detection and 
      grading of CIPN. METHODS: Consecutive patients, aged 18 years or older, 
      candidates for neurotoxic chemotherapy, were enrolled in the United States, 
      European Union, or Australia. A trained investigator performed physician-based 
      scales (Total Neuropathy Score-clinical [TNSc], used to calculate Total 
      Neuropathy Score-nurse [TNSn]) and supervised the patient-completed questionnaire 
      (Functional Assessment of Cancer Treatment/Gynecologic Oncology 
      Group-Neurotoxicity [FACT/GOG-NTX]). Evaluations were performed before and at the 
      end of chemotherapy. On participants without neuropathy at baseline, we assessed 
      the association between TNSc, TNSn, and FACT/GOG-NTX. Considering a previously 
      established minimal clinically important difference (MCID) for FACT/GOG-NTX, we 
      identified participants with and without a clinically important deterioration 
      according to this scale. Then, we calculated the MCID for TNSc and TNSn as the 
      difference in the mean change score of these scales between the 2 groups. 
      RESULTS: Data from 254 participants were available: 180 (71%) had normal 
      neurologic status at baseline. At the end of the study, 88% of participants 
      developed any grade of neuropathy. TNSc, TNSn, and FACT/GOG-NTX showed good 
      responsiveness (standardized mean change from baseline to end of chemotherapy >1 
      for all scales). On the 153 participants without neuropathy at baseline and 
      treated with a known neurotoxic chemotherapy regimen, we verified a moderate 
      correlation in both TNSc and TNSn scores with FACT/GOG-NTX (Spearman correlation 
      index r = 0.6). On the same sample, considering as clinically important a change 
      in the FACT/GOG-NTX score of at least 3.3 points, the MCID was 3.7 for TNSc and 
      2.8 for the TNSn. CONCLUSIONS: MCID for TNSc and TNSn were calculated and the 
      TNSn can be considered a reliable alternative objective clinical assessment if a 
      more extended neurologic examination is not possible. The FACT/GOG-NTX score can 
      be reduced to 7 items and these items correlate well with the TNSc and TNSn. 
      CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that a 
      patient-completed questionnaire and nurse-assessed scale correlate with a 
      physician-assessed scale.
CI  - (c) 2021 American Academy of Neurology.
FAU - Alberti, Paola
AU  - Alberti P
AUID- ORCID: 0000-0001-6106-6183
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Bernasconi, Davide P
AU  - Bernasconi DP
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Cornblath, David R
AU  - Cornblath DR
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Merkies, Ingemar S J
AU  - Merkies ISJ
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Park, Susanna B
AU  - Park SB
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Velasco, Roser
AU  - Velasco R
AUID- ORCID: 0000-0003-3194-9406
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Bruna, Jordi
AU  - Bruna J
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Psimaras, Dimitri
AU  - Psimaras D
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Koeppen, Susanne
AU  - Koeppen S
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Pace, Andrea
AU  - Pace A
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Dorsey, Susan G
AU  - Dorsey SG
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Argyriou, Andreas A
AU  - Argyriou AA
AUID- ORCID: 0000-0003-2131-7114
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Kalofonos, Haralabos P
AU  - Kalofonos HP
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Briani, Chiara
AU  - Briani C
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Schenone, Angelo
AU  - Schenone A
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Faber, Catharina G
AU  - Faber CG
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Mazzeo, Anna
AU  - Mazzeo A
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Grisold, Wolfgang
AU  - Grisold W
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Valsecchi, MariaGrazia
AU  - Valsecchi M
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria.
FAU - Cavaletti, Guido
AU  - Cavaletti G
AUID- ORCID: 0000-0003-4128-2406
AD  - From Experimental Neurology Unit (P.A., G.C.) and Bicocca Bioinformatics 
      Biostatistics and Bioimaging Centre-B4 (D.P.B., M.G.V.), School of Medicine and 
      Surgery, University of Milano-Bicocca, Monza; NeuroMI (Milan Center for 
      Neuroscience) (P.A., G.C.), Milan, Italy; Johns Hopkins University School of 
      Medicine (D.R.C.), Baltimore, MD; Department of Neurology (I.S.J.M., C.G.F.), 
      Maastricht University Medical Centre, the Netherlands; Department of Neurology 
      (I.S.J.M.), St Elisabeth Hospital, Willemstad, Curacao; University of New South 
      Wales (S.B.P.), Sydney, Australia; Unit of Neuro-Oncology, Neurology Department 
      (R.V., J.B.), Hospital Universitari de Bellvitge-ICO l'Hospitalet, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona; Institute of Neurosciences and Department 
      of Cell Biology, Physiology and Immunology (R.V., J.B.), Universitat Autonoma de 
      Barcelona, Centro de Investigacion Biomedica en Red sobre Enfermedades 
      Neurodegenerativas (CIBERNED), Bellaterra, Spain; Service de Neurologie Mazarin 
      (D.P.), Hopital de la Pitie-Salpetriere, Universite Paris Sorbonne, Paris, 
      France; Department of Neurology and West German Cancer Center (S.K.), University 
      of Essen, Germany; IRCCS Regina Elena Cancer Institute (A.P.), Neuro-Oncology 
      Unit, Rome, Italy; Department of Pain & Translational Symptom Science (S.G.D.), 
      University of Maryland Baltimore; Neurological Department (A.A.A.), Saint 
      Andrew's General Hospital of Patras; Department of Medicine, Division of Oncology 
      (A.A.A., H.P.K.), Medical School, University of Patras, Greece; Department of 
      Neurosciences (C.B.), University of Padova; Department of Neurosciences, 
      Rehabilitation, Ophthalmology, Genetic and Maternal and Infantile Sciences 
      (DINOGMI) (A.S.), University of Genova; Unit of Neurology and Neuromuscular 
      Diseases (A.M.), Department of Clinical and Experimental Medicine, University of 
      Messina, Italy; and Ludwig Boltzmann Institute for Experimental und Clinical 
      Traumatology (W.G.), Vienna, Austria. guido.cavaletti@unimib.it.
CN  - CI-PeriNomS group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20210602
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Agents/*toxicity
MH  - Diagnostic Techniques, Neurological/*standards
MH  - Humans
MH  - Middle Aged
MH  - Neoplasms/*drug therapy
MH  - Neurotoxicity Syndromes/*diagnosis/etiology
MH  - Nurses
MH  - Patients
MH  - Peripheral Nervous System Diseases/chemically induced/*diagnosis
MH  - Physicians
MH  - Prospective Studies
MH  - Psychometrics/instrumentation/*standards
MH  - *Severity of Illness Index
MH  - Young Adult
PMC - PMC10365895
COIS- The authors report no disclosures relevant to the manuscript. Go to 
      Neurology.org/N for full disclosures.
FIR - Cazzaniga, Marina Elena
IR  - Cazzaniga ME
FIR - Longarini, Raffaella
IR  - Longarini R
FIR - Guidi, Alessandro
IR  - Guidi A
FIR - Postma, Tjeerd J
IR  - Postma TJ
FIR - Goldstein, David
IR  - Goldstein D
FIR - Ricard, Damien
IR  - Ricard D
FIR - Tafani, Camille
IR  - Tafani C
FIR - Brooks, DuBose
IR  - Brooks D
FIR - Renn, Cynthia L
IR  - Renn CL
FIR - Galie, Edvina
IR  - Galie E
FIR - Campagnolo, Marta
IR  - Campagnolo M
FIR - Castellani, Francesca
IR  - Castellani F
FIR - Grandis, Marina
IR  - Grandis M
FIR - Lalisang, Roy I
IR  - Lalisang RI
FIR - Gentile, Luca
IR  - Gentile L
FIR - Russo, Massimo
IR  - Russo M
FIR - Toscano, Antonio
IR  - Toscano A
EDAT- 2021/06/04 06:00
MHDA- 2021/08/25 06:00
PMCR- 2021/08/17
CRDT- 2021/06/03 05:52
PHST- 2020/11/09 00:00 [received]
PHST- 2021/05/07 00:00 [accepted]
PHST- 2021/06/04 06:00 [pubmed]
PHST- 2021/08/25 06:00 [medline]
PHST- 2021/06/03 05:52 [entrez]
PHST- 2021/08/17 00:00 [pmc-release]
AID - WNL.0000000000012300 [pii]
AID - NEUROLOGY2020152231 [pii]
AID - 10.1212/WNL.0000000000012300 [doi]
PST - ppublish
SO  - Neurology. 2021 Aug 17;97(7):e660-e672. doi: 10.1212/WNL.0000000000012300. Epub 
      2021 Jun 2.