PMID- 34078816
OWN - NLM
STAT- MEDLINE
DCOM- 20211129
LR  - 20240226
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 44
IP  - 6
DP  - 2021
TI  - Naturally Oxidized Olive Oil Promotes Active Cutaneous Anaphylaxis and Th2 
      Cytokine Production.
PG  - 838-843
LID - 10.1248/bpb.b21-00065 [doi]
AB  - The excessive ingestion of oxidized dietary oils may exacerbate some allergic 
      diseases. We previously reported that oxidized olive oil exacerbates active 
      cutaneous anaphylaxis (ACA), one of the immediate allergic reactions. This study 
      was conducted to clarify the effects of oxidized olive oil on the T cell response 
      during ACA. BALB/c female mice were orally administered naturally oxidized olive 
      oil once every 2 d for 2 weeks after ovalbumin (OVA)/aluminum hydroxide gel 
      sensitization, after which ACA was elicited by intracutaneous administration of 
      OVA into the ear auricles. Compared with fresh olive oil, oxidized olive oil 
      administration increased the antigen-specific immunoglobulin E (IgE) antibody 
      titer 2 weeks after OVA-sensitization and vascular hyperpermeability increased 
      due to ACA. In the oxidized olive oil-administered mice, the mRNA expression 
      levels of T-helper 2 (Th2) cytokines, interleukin (IL)-4, -5, -6, and -10, in the 
      lymph nodes increased, as did the proportion of cluster designation 
      (CD)3(+)CD4(+) cells in the spleen and lymph nodes. In CD3(+)CD4(+) cells, the 
      mRNA expression levels of IL-4 and GATA-binding protein 3 (GATA3), the master 
      regulator of Th2, were higher in the oxidized olive oil-group. Antigen-stimulated 
      specific IL-4 production was promoted in CD3(+)CD4(+) cells of oxidized olive 
      oil-administered mice. This suggests that oxidized olive oil exacerbates ACA by 
      promoting Th2 dominance in immediate allergic diseases.
FAU - Ogino, Hirofumi
AU  - Ogino H
AD  - Department of Public Health & Preventive Pharmacology, Faculty of Pharmaceutical 
      Sciences, Setsunan University.
FAU - Okuno, Tomofumi
AU  - Okuno T
AD  - Department of Public Health & Preventive Pharmacology, Faculty of Pharmaceutical 
      Sciences, Setsunan University.
FAU - Murano, Koichi
AU  - Murano K
AD  - Division of Hygienic Chemistry, Osaka Institute of Public Health.
FAU - Ueno, Hitoshi
AU  - Ueno H
AD  - Department of Public Health & Preventive Pharmacology, Faculty of Pharmaceutical 
      Sciences, Setsunan University.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Cytokines)
RN  - 0 (Olive Oil)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Anaphylaxis/genetics/*immunology
MH  - Animals
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - Cytokines/genetics/immunology
MH  - Female
MH  - Immunoglobulin E/immunology
MH  - Lymph Nodes/immunology
MH  - Macrophages, Peritoneal/immunology
MH  - Mice, Inbred BALB C
MH  - *Olive Oil
MH  - Oxidation-Reduction
MH  - Skin Diseases/genetics/*immunology
MH  - Spleen/cytology
MH  - T-Lymphocytes/immunology
MH  - Mice
OTO - NOTNLM
OT  - active cutaneous anaphylaxis
OT  - allergic disease
OT  - lipid peroxide
OT  - oxidative stress
OT  - oxidized oil
EDAT- 2021/06/04 06:00
MHDA- 2021/11/30 06:00
CRDT- 2021/06/03 05:54
PHST- 2021/06/03 05:54 [entrez]
PHST- 2021/06/04 06:00 [pubmed]
PHST- 2021/11/30 06:00 [medline]
AID - 10.1248/bpb.b21-00065 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2021;44(6):838-843. doi: 10.1248/bpb.b21-00065.