PMID- 34079236
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220423
IS  - 1177-889X (Print)
IS  - 1177-889X (Electronic)
IS  - 1177-889X (Linking)
VI  - 15
DP  - 2021
TI  - Caregivers of Patients with Heart Failure: Burden and the Determinants of 
      Health-Related Quality of Life.
PG  - 1153-1164
LID - 10.2147/PPA.S297816 [doi]
AB  - PURPOSE: To assess the burden among caregivers of patients with heart failure 
      (HF) with left ventricular ejection fraction (LVEF) </=60%. The burden by New York 
      Heart Association (NYHA) functional class was also characterized. PATIENTS AND 
      METHODS: A cross-sectional study was conducted in France, Germany, Italy, Spain, 
      and UK from June to November 2019. Patient record forms were completed by 257 
      cardiologists and 158 general practitioners for consecutive HF patients. 
      Caregivers who accompanied the patient to their consultation completed a 
      caregiver self-completion survey voluntarily, which included the Family Caregiver 
      Quality of Life Questionnaire (FAMQOL) and 5-level 5-dimension EuroQol 
      questionnaire (EQ-5D-5L). RESULTS: We analyzed 361 caregivers of patients with HF 
      (NYHA class I, n=41; II, n=212; III IV, n=108). Mean age of caregivers was 58.8 
      years (NYHA I/II/III-IV: 59.1/60.8/54.6 years; p=0.0029), with majority being 
      females (73.1%). Caregivers spent on average 19.8 hours/week caring for a HF 
      patient, which increased with increase in NYHA class (I/II/III-IV: 11.8/18.1/25.9 
      hours/week; p=0.0094). Caregivers (24.1%) reported providing emotional 
      support/encouragement to patients as the most troublesome/inconvenient caregiving 
      activity (no significant difference across NYHA class). Nearly one-third of 
      caregivers experienced stress (NYHA I/II/III-IV: 17.1%/28.8%/40.7%; p=0.0111) and 
      anxiety (26.8%/24.1%/39.8%; p=0.0127) due to caregiving burden. The overall 
      FAMQOL mean score decreased significantly (poorer QoL) with increase in NYHA 
      class (I/II/III-IV: 58.1/56.3/52.2; p=0.0069). A trend of decreasing scores with 
      increasing NYHA class was observed across physical, emotional, and social domains 
      (each p</=0.012). CONCLUSION: Caregivers of HF patients with LVEF </=60% experienced 
      a significant burden, which was higher among caregivers of patients with more 
      severe and symptomatic disease.
CI  - (c) 2021 Lahoz et al.
FAU - Lahoz, Raquel
AU  - Lahoz R
AUID- ORCID: 0000-0002-7968-7073
AD  - Real World Evidence, Cardiovascular, Renal and Metabolism Franchise, Novartis 
      Pharma AG, Basel, Switzerland.
FAU - Proudfoot, Clare
AU  - Proudfoot C
AD  - Health Economics and Outcomes Research, Cardiovascular, Renal and Metabolism 
      Franchise, Novartis Pharma AG, Basel, Switzerland.
FAU - Fonseca, Ana Filipa
AU  - Fonseca AF
AD  - Real World Evidence, Cardiovascular, Renal and Metabolism Franchise, Novartis 
      Pharma AG, Basel, Switzerland.
FAU - Loefroth, Emil
AU  - Loefroth E
AD  - Real World Evidence, Cardiovascular, Renal and Metabolism Franchise, Novartis 
      Pharma AG, Basel, Switzerland.
FAU - Corda, Stefano
AU  - Corda S
AD  - Global Medical Affairs, Cardiovascular, Renal and Metabolism Franchise, Novartis 
      Pharma AG, Basel, Switzerland.
FAU - Jackson, James
AU  - Jackson J
AUID- ORCID: 0000-0002-4171-5390
AD  - Real World Research, Adelphi Real World, Bollington, UK.
FAU - Cotton, Sarah
AU  - Cotton S
AUID- ORCID: 0000-0003-1158-6345
AD  - Real World Research, Adelphi Real World, Bollington, UK.
FAU - Studer, Rachel
AU  - Studer R
AUID- ORCID: 0000-0002-4321-6210
AD  - Real World Evidence, Cardiovascular, Renal and Metabolism Franchise, Novartis 
      Pharma AG, Basel, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20210526
PL  - New Zealand
TA  - Patient Prefer Adherence
JT  - Patient preference and adherence
JID - 101475748
PMC - PMC8165301
OTO - NOTNLM
OT  - NYHA class
OT  - burden
OT  - caregiver
OT  - heart failure
OT  - quality of life
OT  - real world evidence
COIS- R. Lahoz, C. Proudfoot, A. F. Fonseca, E. Loefroth, S. Corda and R. Studer are 
      employees of Novartis Pharma AG, Basel, Switzerland. J. Jackson and S. Cotton are 
      employees of Adelphi Real World, Bollington, United Kingdom and were contracted 
      by Novartis to conduct this study. The authors report no other conflicts of 
      interest in this work.
EDAT- 2021/06/04 06:00
MHDA- 2021/06/04 06:01
PMCR- 2021/05/26
CRDT- 2021/06/03 06:37
PHST- 2021/01/15 00:00 [received]
PHST- 2021/04/29 00:00 [accepted]
PHST- 2021/06/03 06:37 [entrez]
PHST- 2021/06/04 06:00 [pubmed]
PHST- 2021/06/04 06:01 [medline]
PHST- 2021/05/26 00:00 [pmc-release]
AID - 297816 [pii]
AID - 10.2147/PPA.S297816 [doi]
PST - epublish
SO  - Patient Prefer Adherence. 2021 May 26;15:1153-1164. doi: 10.2147/PPA.S297816. 
      eCollection 2021.