PMID- 34080214
OWN - NLM
STAT- MEDLINE
DCOM- 20220420
LR  - 20220420
IS  - 1745-4514 (Electronic)
IS  - 0145-8884 (Linking)
VI  - 46
IP  - 3
DP  - 2022 Mar
TI  - Effects of Citri Reticulatae Pericarpium and grapefruit juice on the 
      pharmacokinetics of omeprazole in rats.
PG  - e13804
LID - 10.1111/jfbc.13804 [doi]
AB  - The effects of Citri Reticulatae Pericarpium (CRP) and grapefruit juice (GFJ) on 
      the pharmacokinetics of omeprazole were investigated in this study. 
      Sprague-Dawley rats were pretreated with CRP decoction or GFJ for 28 consecutive 
      days. After a single intragastric administration of 6.0 mg/kg, the concentration 
      of omeprazole in the plasma was determined by high-performance liquid 
      chromatography (HPLC), and the pharmacokinetic parameters were calculated by 
      Kinetica software 5.0. A high-performance liquid 
      chromatography-quadrupole-time-of-flight mass spectrometry (HPLC-Q-TOF-MS) method 
      was established to identify the chemical components in CRP decoction and GFJ. The 
      results showed that the AUC(t)(-infinity) was significantly increased when 
      coadministrated with CRP. The AUC(0-)(t) and AUC(0-infinity) was remarkably increased; 
      the Cl was decreased when coadministrated with GFJ. A total of 31 and 28 
      bioactive compounds were identified in the CRP decoction and GFJ, respectively. 
      Flavonoids and furanocoumarins, including hesperidin, hesperetin, naringenin, 
      sinensetin, tangeretin, nobiletin, and 6',7'-dihydroxybergamottin, were 
      simultaneously identified in CRP decoction and GFJ. This study indicates that the 
      increased bioavailability of omeprazole may be due to the inhibition of hepatic 
      cytochrome P450 enzymes, and the systemic exposure should be monitored when 
      concomitant administration with CRP and GFJ. PRACTICAL APPLICATIONS: Citri 
      Reticulatae Pericarpium (CRP) has been widely consumed as a daily condiment, 
      functional food, and a traditional Chinese medicine. Omeprazole, primary 
      metabolized by CYP450 enzymes, was usually coadministered with CRP for the 
      treatment of gastrointestinal disease. Studies have confirmed that much fruit 
      juices, including grapefruit juice, may affect drug metabolism enzymes. CRP and 
      grapefruit (Citrus paradisi Macf.) belong to the genus Citrus and family Rutaceae 
      with different species. Therefore, the pharmacokinetic interaction of CRP 
      decoction and grapefruit juice with omeprazole is worthy of attention. The 
      results of this study can provide basic pharmacological data support for the safe 
      and effective clinical use of omeprazole. It can also provide a theoretical basis 
      for the development of new functional products and daily application of CRP.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Zhang, Yan
AU  - Zhang Y
AUID- ORCID: 0000-0002-5026-7446
AD  - School of Preclinical Medicine, Chengdu University, Chengdu, China.
FAU - Yu, Yiping
AU  - Yu Y
AD  - School of Pharmacy, Shandong College of Traditional Chinese Medicine, Yantai, 
      China.
FAU - Li, Hong
AU  - Li H
AD  - Department of Pharmacology, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, China.
FAU - Huang, Wenge
AU  - Huang W
AD  - Department of Pharmacology, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, China.
FAU - Wang, Ping
AU  - Wang P
AD  - Department of Pharmacology, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210602
PL  - United States
TA  - J Food Biochem
JT  - Journal of food biochemistry
JID - 7706045
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Animals
MH  - Chromatography, High Pressure Liquid/methods
MH  - *Citrus paradisi/chemistry
MH  - Fruit and Vegetable Juices
MH  - Omeprazole
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Citri Reticulatae Pericarpium
OT  - grapefruit juice
OT  - herb-drug interaction
OT  - omeprazole
OT  - pharmacokinetics
EDAT- 2021/06/04 06:00
MHDA- 2022/04/21 06:00
CRDT- 2021/06/03 06:57
PHST- 2021/04/10 00:00 [revised]
PHST- 2020/12/02 00:00 [received]
PHST- 2021/05/07 00:00 [accepted]
PHST- 2021/06/04 06:00 [pubmed]
PHST- 2022/04/21 06:00 [medline]
PHST- 2021/06/03 06:57 [entrez]
AID - 10.1111/jfbc.13804 [doi]
PST - ppublish
SO  - J Food Biochem. 2022 Mar;46(3):e13804. doi: 10.1111/jfbc.13804. Epub 2021 Jun 2.