PMID- 34080240
OWN - NLM
STAT- MEDLINE
DCOM- 20220112
LR  - 20220112
IS  - 1097-0231 (Electronic)
IS  - 0951-4198 (Linking)
VI  - 35
IP  - 15
DP  - 2021 Aug 15
TI  - Rapid detection of nine synthetic cathinones in blood and urine by direct 
      analysis in real-time-tandem mass spectrometry.
PG  - e9136
LID - 10.1002/rcm.9136 [doi]
AB  - RATIONALE: Designer drugs of cathinone, a kind of hallucinogen, were abused in 
      the recent years. They were also known as bath salts, plant fertilizers, and 
      zombie potions in drug market. The abuse of synthetic cathinones caused many bad 
      effects on social order. Rapid detection of synthetic cathinones became an 
      important subject of study in forensic science. METHODS: Direct analysis in 
      real-time-tandem mass spectrometry (DART-MS/MS) was used to develop an effective 
      method on nine synthetic cathinones in human whole blood and urine. The reference 
      materials with 100 ng/mL were prepared for mass spectrometry optimization with 
      electrospray ionization (ESI) probe tandem QTRAP 4000 mass spectrometer. The 
      temperature of DART ion source was optimized to 400 degrees C. The volumes of 4/1 (v/v) 
      MeCN/MeOH with 0.69 mL were selected for the preparation of 0.31 mL blood and 
      urine samples, respectively. Then the spiked analytes were prepared for detection 
      by the DART 12Dip-it autosampler module. RESULTS: The results showed that the 
      linearities range between 0.1 and 5 mug/mL, the correlation coefficients (r(2) ) 
      ranged from 0.99 to 1, the limits of detection (LODs) were all between 0.5 and 
      50 ng/mL, and the relative standard deviations (RSDs) of repeatability, intra-day 
      and inter-day precisions were all below 13% and 14% in blood and urine, 
      respectively. CONCLUSION: The results indicated that the method could meet the 
      needs of rapid screening of samples that may contain synthetic cathinones. In 
      addition, the method developed has many advantages, such as efficient, fast 
      sample preparation, and environmental protection. Therefore, the DART-MS/MS 
      method would provide effective data support for rapid screening of synthetic 
      cathinones in forensic science.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Ji, Jiahua
AU  - Ji J
AUID- ORCID: 0000-0002-7847-0331
AD  - School of Criminal Investigation, People's Public Security University of China, 
      Beijing, 100038, China.
FAU - Zhang, Ying
AU  - Zhang Y
AD  - Forensic Science Service of Beijing Public Security Bureau, Key Laboratory of 
      Forensic Toxicology, Ministry of Public Security, Beijing, 100192, China.
FAU - Wang, Jifen
AU  - Wang J
AD  - School of Criminal Investigation, People's Public Security University of China, 
      Beijing, 100038, China.
LA  - eng
GR  - 2021JKF208/Fundamental Research Funds for the Central Universities/
GR  - 2018GABJC29/Project for Strengthening the Police Force with Science and 
      Technology/
PT  - Journal Article
PL  - England
TA  - Rapid Commun Mass Spectrom
JT  - Rapid communications in mass spectrometry : RCM
JID - 8802365
RN  - 0 (Alkaloids)
RN  - 540EI4406J (cathinone)
SB  - IM
MH  - Alkaloids/*blood/chemistry/*urine
MH  - Humans
MH  - Limit of Detection
MH  - Linear Models
MH  - Reproducibility of Results
MH  - Tandem Mass Spectrometry/*methods
EDAT- 2021/06/04 06:00
MHDA- 2022/01/13 06:00
CRDT- 2021/06/03 06:59
PHST- 2021/05/11 00:00 [revised]
PHST- 2021/03/30 00:00 [received]
PHST- 2021/05/31 00:00 [accepted]
PHST- 2021/06/04 06:00 [pubmed]
PHST- 2022/01/13 06:00 [medline]
PHST- 2021/06/03 06:59 [entrez]
AID - 10.1002/rcm.9136 [doi]
PST - ppublish
SO  - Rapid Commun Mass Spectrom. 2021 Aug 15;35(15):e9136. doi: 10.1002/rcm.9136.