PMID- 34080554
OWN - NLM
STAT- MEDLINE
DCOM- 20210913
LR  - 20210913
IS  - 1873-6483 (Electronic)
IS  - 0740-5472 (Linking)
VI  - 129
DP  - 2021 Oct
TI  - Clinical and psychological factors associated with interdose opioid withdrawal in 
      chronic pain population.
PG  - 108386
LID - S0740-5472(21)00112-4 [pii]
LID - 10.1016/j.jsat.2021.108386 [doi]
AB  - BACKGROUND: The DSM-5 diagnostic criteria for Prescription Opioid-Use Disorder 
      (POUD) have undergone some significant changes. One of the most controversial 
      changes has been the elimination of the withdrawal symptoms criterion when opioid 
      use is under appropriate medical supervision. For this reason, the goal of this 
      study was to analyze factors associated with opioid withdrawal in patients with 
      chronic non-cancer pain (CNCP). METHODS: This cross-sectional descriptive study 
      involved 404 patients who use prescription opioids for long-term treatment 
      (>/=90 days) of CNCP. Measures included sociodemographic and clinical 
      characteristics, POUD, withdrawal symptoms, craving, anxiety-depressive symptoms, 
      and pain intensity and interference. RESULTS: Forty-seven percent (n = 193) of 
      the sample reported moderate-severe withdrawal symptoms, which were associated 
      with lower age, higher daily morphine dose and duration of treatment with 
      opioids, moderate-severe POUD, use of psychotropic drugs, higher 
      anxiety-depressive symptoms, and greater pain intensity and interference 
      (p < .05). Binary logistic regression analysis showed that moderate-severe POUD 
      (OR = 2.82), anxiety (OR = 2.21), depression (OR = 1.81), higher pain 
      interference (OR = 1.05), and longer duration of treatment with opioids were the 
      strongest factors associated with moderate-severe withdrawal symptoms (p < .05). 
      CONCLUSION: Psychological factors seem to play a key role in the severity of 
      withdrawal symptoms. Since greater intensity of these symptoms increases the risk 
      of developing POUD, knowing the factors associated with withdrawal may be useful 
      in developing preventive psychological interventions.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Rodriguez-Espinosa, Sara
AU  - Rodriguez-Espinosa S
AD  - Center for Applied Psychology, Miguel Hernandez University, Avenida Universidad, 
      s/n, 03202 Elche, Spain.
FAU - Coloma-Carmona, Ainhoa
AU  - Coloma-Carmona A
AD  - Center for Applied Psychology, Miguel Hernandez University, Avenida Universidad, 
      s/n, 03202 Elche, Spain.
FAU - Perez-Carbonell, Ana
AU  - Perez-Carbonell A
AD  - University General Hospital of Elche, Camino de la Almazara, 11, 03203 Elche, 
      Spain.
FAU - Roman-Quiles, Jose F
AU  - Roman-Quiles JF
AD  - University General Hospital of Elche, Camino de la Almazara, 11, 03203 Elche, 
      Spain.
FAU - Carballo, Jose L
AU  - Carballo JL
AD  - Center for Applied Psychology, Miguel Hernandez University, Avenida Universidad, 
      s/n, 03202 Elche, Spain. Electronic address: jcarballo@umh.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210408
PL  - United States
TA  - J Subst Abuse Treat
JT  - Journal of substance abuse treatment
JID - 8500909
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Analgesics, Opioid/adverse effects
MH  - *Chronic Pain/drug therapy
MH  - Cross-Sectional Studies
MH  - Humans
MH  - *Opioid-Related Disorders/drug therapy/epidemiology
MH  - *Substance Withdrawal Syndrome/drug therapy
OTO - NOTNLM
OT  - Chronic pain
OT  - DSM-5
OT  - Prescription Opioid-Use Disorder
OT  - Withdrawal symptoms
EDAT- 2021/06/04 06:00
MHDA- 2021/09/14 06:00
CRDT- 2021/06/03 08:42
PHST- 2020/11/03 00:00 [received]
PHST- 2021/03/18 00:00 [revised]
PHST- 2021/03/24 00:00 [accepted]
PHST- 2021/06/04 06:00 [pubmed]
PHST- 2021/09/14 06:00 [medline]
PHST- 2021/06/03 08:42 [entrez]
AID - S0740-5472(21)00112-4 [pii]
AID - 10.1016/j.jsat.2021.108386 [doi]
PST - ppublish
SO  - J Subst Abuse Treat. 2021 Oct;129:108386. doi: 10.1016/j.jsat.2021.108386. Epub 
      2021 Apr 8.